NCT06379282

Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 132 (estimated)
• Sponsor: University of Surrey · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This randomised control clinical trial aims to investigate the effects of exercise training and diet on physical and functional fitness and immunological and metabolic changes in adults with chronic lymphocytic leukaemia. Investigators will randomise participants to either 12 weeks of supervised/semi-supervised exercise only, exercise + nutritional guidance, or no exercise.

Detailed description

This study aims to perform a randomised control trial of exercise or exercise plus nutritional guidance on the physiological and immunological health of adults diagnosed with chronic lymphocytic leukaemia (CLL). Recruited participants will be randomised to either 12 weeks of an exercise-only program, an exercise-plus nutritional guidance program or a no-exercise control group. Fasting blood samples collected at Baseline and 12 weeks will measure absolute CLL cell counts, immune function, and inflammatory and metabolic biomarkers. A series of physical fitness assessments will be assessed at baseline and 12 weeks to determine physiologic reserve and resilience against external stressors. Additionally, participants will be asked to return 12 weeks after completing the intervention to assess the legacy effects of the intervention on the same physiological and blood-based biomarkers of health.

Conditions

• Chronic Lymphocytic Leukemia
• Frailty
• Muscle Function
• Immune Function
• Lipid Cell; Tumor

Interventions

Type	Name	Description
BEHAVIORAL	HIT	Exercise training only
BEHAVIORAL	EXE+ Nutritional Guidance	Exercise Training + Nutritional Guidance

Timeline

• Start date: 2022-10-14
• Primary completion: 2025-08-01
• Completion: 2026-08-01
• First posted: 2024-04-23
• Last updated: 2024-04-24

Locations

1 site across 1 country: United Kingdom