| Not Yet Recruiting | Small Trial of Alendronate Impact on the Reservoir of HIV HIV | Phase 2 | 2026-06-27 |
| Recruiting | BPL-1357 Against H1N1 Influenza Virus Challenge Influenza, Human | Phase 2 | 2026-06-23 |
| Not Yet Recruiting | A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT1 HIV-1-infection | Phase 1 | 2026-06-12 |
| Not Yet Recruiting | A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 1 Tuberculosis | Phase 1 / Phase 2 | 2026-05-15 |
| Recruiting | Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocogni Major Depressive Disorder, Mild Neurocognitive Disorder, HIV | Phase 2 | 2026-04-30 |
| Not Yet Recruiting | Dasatinib for HIV-1 Reservoir Reduction HIV Infections | Phase 1 | 2026-04-30 |
| Not Yet Recruiting | A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal an COVID-19 | Phase 1 | 2026-04-29 |
| Enrolling By Invitation | Rechallenge With a Low Pathogenicity Avian H10N7 Influenza Virus in Healthy Human Volunteers Previously Challe Influenza Infection, Infections, Respiratory Virus Infections | Phase 1 | 2026-04-22 |
| Recruiting | Modeling Host-Pathogen Interaction Using Lymphoid Organoids Staphylococcal Infections | — | 2026-04-22 |
| Enrolling By Invitation | Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens) Healthy Volunteer Samples | — | 2026-04-22 |
| Recruiting | The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dys Dysphagia, Eosinophilic Esophagitis | N/A | 2026-04-22 |
| Recruiting | Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thy Down Syndrome | — | 2026-04-22 |
| Recruiting | THREAT: Testing Harms Related to Exposure to Allergenic and Epithelial Toxins Allergic, Inflammatory | N/A | 2026-04-22 |
| Recruiting | Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study Healthy Volunteer, Weight Gain, Metabolic Effects | Phase 2 | 2026-04-22 |
| Suspended | Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) Malaria | Phase 1 | 2026-04-22 |
| Recruiting | Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease an Hyper IgE Syndrome From STAT3 Mutation, Job s Syndrome, HIES | Phase 1 | 2026-04-22 |
| Not Yet Recruiting | Treatment of Antibody-Mediated Rejection (ABMR) With CarBel Kidney Transplant Rejection | Phase 2 | 2026-04-15 |
| Not Yet Recruiting | Study of Oral Food Challenge Biomarkers (SAFER) Allergy | — | 2026-04-01 |
| Recruiting | Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV2 HIV | Phase 1 | 2026-03-25 |
| Not Yet Recruiting | LYmph Node eXamination in Cat Allergen Immunotherapy Allergy | EARLY_Phase 1 | 2026-03-19 |
| Recruiting | A Study of Safety and Drug Levels of ePGT121v1-LS, PGDM1400LS, and VRC07-523LS in Adult Participants Without H HIV | Phase 1 | 2026-03-19 |
| Not Yet Recruiting | Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial Hypoxemia, Severe Acute Respiratory Syndrome | Phase 4 | 2026-03-01 |
| Withdrawn | L9LS-R21 Interaction Malaria | Phase 2 | 2026-03-01 |
| Not Yet Recruiting | Study of the Pharmacokinetics and Safety of Glecaprevir/Pibrentasvir Initiated in Pregnancy in Women With Hepa Hepatitis C | Phase 1 / Phase 2 | 2026-02-28 |
| Recruiting | Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy Autoimmune Disorders | Phase 2 | 2026-02-26 |
| Not Yet Recruiting | Efficacy of Tezepelumab in Peanut Oral Immunotherapy Peanut Allergy | Phase 2 | 2026-02-18 |
| Recruiting | Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults COVID-19 | Phase 1 | 2026-02-02 |
| Recruiting | EVR and EPO for Liver Transplant Tolerance Liver Transplant | Phase 1 | 2026-01-21 |
| Recruiting | Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving An Human Immunodeficiency Virus | Phase 1 | 2026-01-20 |
| Recruiting | Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Expose HIV-1 | Phase 1 | 2026-01-05 |
| Recruiting | Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Controlled Giant Cell Arteritis Giant Cell Arteritis (GCA) | Phase 2 | 2025-12-11 |
| Recruiting | A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes COVID-19 | Phase 1 | 2025-12-05 |
| Active Not Recruiting | Improving Physical Ability and Cellular Senescence Elimination in HIV HIV, Frailty, Prefrail | Phase 2 | 2025-12-04 |
| Withdrawn | Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Bu Severe Combined Immune Deficiency (SCID) | Phase 1 / Phase 2 | 2025-11-26 |
| Withdrawn | Safety and Challenge Study of BCG TICE(R) Vaccination to Test Tuberculosis Immunity in Heathy Humans Tuberculosis | Phase 1 | 2025-11-26 |
| Recruiting | Randomized Stepped Wedge Study of Emapalumab in APECED Enteritis Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Enteritis | Phase 2 | 2025-11-12 |
| Recruiting | Microbiome and Atopy in Mali Atopic Disease | — | 2025-09-30 |
| Recruiting | Improving Deceased-Donor Kidney Transplant Outcomes Via a Single Intragraft Injection of C1 Esterase Inhibitor Kidney Transplant | Phase 2 | 2025-09-22 |
| Recruiting | First-in-Human Study of VNT-101: Safety, Tolerability, and Pharmacokinetics Influenza | Phase 1 | 2025-09-16 |
| Recruiting | Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRI HIV Infections | Phase 1 | 2025-09-14 |
| Recruiting | Repeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide t Cryopyrin-Associated Periodic Syndromes, Amyloidosis | Phase 1 | 2025-09-10 |
| Enrolling By Invitation | Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Dis Chronic Granulomatous Disease (CGD) | Phase 1 / Phase 2 | 2025-09-10 |
| Recruiting | pH1N1 Blinded Challenge Study Influenza | Phase 1 | 2025-09-10 |
| Enrolling By Invitation | Immunologic and Virologic Parameters During Analytical Treatment Interruption Following Combination bNAb Thera HIV | Phase 1 | 2025-09-08 |
| Recruiting | Quadrivalent Influenza HA Stem Vaccine VRC-FLUMOS0122-00-VP (SteMos1) With and Without ALFQ Adjuvant in Health Influenza Prevention, Pandemic Influenza Prevention | Phase 1 | 2025-08-27 |
| Active Not Recruiting | Safety, Reactogenicity, and Immunogenicity Trial of STX-S SARS-CoV-2 Vaccine in Adults COVID-19 | Phase 1 | 2025-08-11 |
| Active Not Recruiting | A Study to Evaluate the Safety and Immunogenicity of the V3-region Directed Immunogens DV700P-RNA Followed by HIV-1-infection | Phase 1 | 2025-08-06 |
| Active Not Recruiting | First-in-Human PfSPZ-LARC2 Vaccination/CHMI Malaria | Phase 1 | 2025-07-23 |
| Recruiting | L9LS in Women of Childbearing Potential in Mali Malaria | Phase 2 | 2025-07-22 |
| Recruiting | Base Editing Hematopoietic Stem Cell and T Cell Gene Therapy for CD40L-HyperIgM Syndrome: Single Patient Study CD40L-HyperIgM Syndrome | Phase 1 / Phase 2 | 2025-07-16 |
| Withdrawn | A Trial of Anti-CD4 Antibody UB-421 in Combination With Optimized Background Antiretroviral Therapy in Patient Multi-Drug Resistant Hiv-1 Infection, HIV-1 Infection | Phase 2 | 2025-07-10 |
| Suspended | A Clinical Trial to Evaluate the Safety and Immunogenicity of Glycan-trimmed HIV-1 Nanoparticle Vaccine (UVAX- HIV-1-infection | Phase 1 | 2025-07-07 |
| Active Not Recruiting | A Study to Evaluate the Safety and Immunogenicity of Two Doses of a Novel H5 Central Antigen mRNA-LNP in Healt Avian Influenza | Phase 1 | 2025-06-12 |
| Recruiting | Study of the Esophageal String Test (EST) for the Diagnosis of Helicobacter Pylori Helicobacter Pylori | N/A | 2025-06-11 |
| Recruiting | Epstein-Barr Virus (EBV) gH/gL/gp42-Ferritin Nanoparticle Vaccine With or Without gp350-Ferritin in Healthy Ad EBV, Epstein-Barr Virus Infection, Infectious Mononucleosis | Phase 1 | 2025-05-29 |
| Completed | Phase 1 Study on Bioavailability, Food Effect, and Drug-Drug Interaction of ALG-097558 Tablets in Healthy Volu COVID-19 | Phase 1 | 2025-05-13 |
| Enrolling By Invitation | Base-Edited Hematopoietic Stem/Progenitor Cell X-Linked Severe Combined Immunodeficiency Gene Therapy X-linked Severe Combined Immunodeficiency, X-SCID, XSCID | Phase 1 / Phase 2 | 2025-05-09 |
| Withdrawn | CREATE - Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy HIV-1-infection, Pregnancy, Postpartum | Phase 1 / Phase 2 | 2025-05-01 |
| Recruiting | Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS Influenza Prevention, Seasonal Influenza | Phase 1 | 2025-04-28 |
| Recruiting | Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2) Atopic Dermatitis | Phase 1 | 2025-04-10 |
| Suspended | Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living With HIV-1 on Suppressi HIV-1 | Phase 1 | 2025-04-01 |
| Completed | Efficacy Study of IM Administered CssBA+dmLT Against Moderate-severe Diarrhea in Human Infection Model With ET Escherichia Infection | Phase 2 | 2025-03-31 |
| Recruiting | Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HIV | Phase 1 | 2025-03-17 |
| Recruiting | Belumosudil to Block Chronic Lung Allograft Dysfunction (CLAD) in High Risk Lung Transplant Recipients Lung Transplant | Phase 2 | 2025-03-12 |
| Recruiting | Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis Pulmonary Tuberculosis | Phase 2 | 2025-03-11 |
| Recruiting | Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lym Autoimmune Lymphoproliferative Syndrome | Phase 2 | 2025-03-10 |
| Recruiting | A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intrave HIV | Phase 2 | 2025-03-07 |
| Active Not Recruiting | Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine in Healthy Adults West Nile Viral Infection | Phase 1 | 2025-02-24 |
| Recruiting | A Safety Assessment of Oral Letermovir in Infants With Symptomatic Congenital Cytomegalovirus Congenital Cytomegalovirus Infection | Phase 1 | 2025-02-19 |
| Recruiting | Optimization of Beta-lactam Dosing in Critically Ill Patients With Cystatin C (OPTIMIZE-GNI) Bacterial Infection | Phase 4 | 2025-02-12 |
| Recruiting | Dupilumab as Add-On Therapy for Hypereosinophilic Syndrome With Partial Clinical Response to Eosinophil-Deplet Hypereosinophilic Syndrome | Phase 2 | 2025-02-05 |
| Recruiting | Belatacept in Heart Transplantation Heart Transplant | Phase 2 | 2025-01-29 |
| Recruiting | A Biorepository of Multiple Allergic Diseases (MADREP) With Longitudinal Follow-Up Allergy, Sinus Disorders, Atopic Diseases, Asthma, Allergic Rhinitis, Atopic Dermatitis, EoE, Drug a | — | 2025-01-28 |
| Withdrawn | Skin Immunity Sample Collection Involving Blisters and Biopsies Hyper-Immunoglobulin E. Syndrome (HEIS), Chronic Granulomatous Disease (CGD) | EARLY_Phase 1 | 2024-12-09 |
| Recruiting | Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Malaria | Phase 1 | 2024-11-26 |
| Active Not Recruiting | A Clinical Trial to Evaluate the Safety and Immunogenicity of CH505M5 N197D mRNA-gp160 Followed by CH505 TF mR HIV Infections | Phase 1 | 2024-11-25 |
| Recruiting | The Tatelo Plus Study HIV, HIV Infections | Phase 1 / Phase 2 | 2024-11-11 |
| Recruiting | A Single-arm, Dose-escalation Trial of Long-acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopa Idiopathic CD4 Lymphopenia | Phase 1 / Phase 2 | 2024-11-06 |
| Recruiting | Characterization of Human Immune Signatures to Zoonotic Virus Exposure in Cambodia Immunity, Humoral | — | 2024-11-01 |
| Active Not Recruiting | CROSSOVER STUDY OF ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR Tenofovir | Phase 2 | 2024-10-29 |
| Recruiting | Cardamom and Topical Roseomonas in Atopic Dermatitis Atopic Dermatitis, Eczema | Phase 2 | 2024-10-09 |
| Completed | Study of a Human Bispecific Antibody VRC-HIVMAB0121-00-AB (CAP256J3LS) Administered Intravenously or Subcutane HIV Infection | Phase 1 | 2024-10-07 |
| Withdrawn | A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immun HIV | Phase 1 | 2024-10-07 |
| Recruiting | High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients Immunization; Infection, Transplantation Infection, Influenza | Phase 2 | 2024-09-26 |
| Completed | Evaluation of the Protective Efficacy of TV003 or Previous Zika Infection Against Infection With ZIKV-SJRP Cha Zika Virus | Phase 1 | 2024-09-24 |
| Active Not Recruiting | The Immunology and Safety of Maternal RSV Vaccination (ABRYSVO), Infant Nirsevimab (BEYFORTUS) Immunization, o Respiratory Syncytial Virus Infection | Phase 4 | 2024-09-19 |
| Recruiting | Expanding Liver Transplant Immunosuppression Minimization Via Everolimus Liver Transplant | Phase 2 | 2024-09-12 |
| Active Not Recruiting | L9LS MAb in Malian Infants Malaria | Phase 1 | 2024-08-19 |
| Recruiting | A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Init Acute HIV Infection | Phase 2 | 2024-08-19 |
| Recruiting | Pregnancy Registry in Mali Malaria, Pregnancy Related | — | 2024-08-05 |
| Completed | Study of the Infectivity, Safety and Immunogenicity of Two Recombinant, Live-Attenuated, B/HPIV3 Vectored Vacc Human Metapneumovirus, Human Parainfluenza Virus Type 3 | Phase 1 | 2024-07-12 |
| Completed | Tecovirimat for Treatment of Monkeypox Virus - Study Extension Providing Standard of Care Only Mpox (Monkeypox) | — | 2024-07-10 |
| Recruiting | Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE St Lymphohistiocytosis, Hemophagocytic, Secondary Hemophagocytic Lymphohistiocytosis, Macrophage Activation Syndrome | — | 2024-07-02 |
| Completed | Safety and Immunogenicity Trial of MPV/S-2P SARS-CoV-2 Vaccine in Adults COVID-19 | Phase 1 | 2024-07-01 |
| Completed | Phase 1, Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of an Ente Enterovirus Infection | Phase 1 | 2024-06-26 |
| Enrolling By Invitation | pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic G p47, Autosomal Recessive, Chronic Granulomatous Disease | Phase 1 / Phase 2 | 2024-06-25 |
| Recruiting | Advancing Transplantation Outcomes in Children Kidney Transplant | Phase 2 | 2024-05-22 |
| Recruiting | CAR-T Cell Therapy for Desensitization in Kidney Transplantation Kidney Transplant, Kidney Failure, End Stage Renal Failure on Dialysis | Phase 1 | 2024-05-09 |
| Recruiting | Protocol CAUSE-03 / CHEETAH Asthma | — | 2024-04-23 |
| Completed | Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Particip Renal Impairment, Tuberculosis | Phase 1 | 2024-04-17 |
| Recruiting | Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous D Chronic Granulomatous Disease (CGD), X-Linked Chronic Granulomatous Disease | Phase 1 / Phase 2 | 2024-04-17 |
| Terminated | Safety Study of SLV213 for the Treatment of COVID-19. COVID-19 | Phase 1 | 2024-04-09 |
| Recruiting | Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During HIV-1-infection | Phase 1 / Phase 2 | 2024-04-01 |
| Active Not Recruiting | Clinical Trial to Evaluate the Safety, Tolerability, and Immunogenicity of 16055 NFL Delta Gly4 Env Protein Tr HIV | Phase 1 | 2024-03-15 |
| Recruiting | Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates Liver Transplant | Phase 2 | 2024-03-05 |
| Completed | Pharmacokinetics and Safety of Double-dose Dolutegravir When Used With Rifapentine for HIV-associated Tubercul HIV-associated Tuberculosis | Phase 2 | 2024-02-13 |
| Recruiting | Tocilizumab in Lung Transplantation Lung Transplant | Phase 2 | 2024-02-13 |
| Recruiting | Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Liv HIV-1-infection | Phase 1 / Phase 2 | 2024-01-24 |
| Completed | A Study of Doxycycline to Treat Chlamydial Infection Chlamydial Infection | Phase 4 | 2024-01-19 |
| Active Not Recruiting | Investigation of Immune Amnesia Following Measles Infection in Select African Regions Measles Infection | — | 2024-01-16 |
| Recruiting | Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity Nervous System Disease, Immune System Disease | — | 2024-01-12 |
| Terminated | Estradiol Therapy In Transgender Women to Research Interactions With HIV Therapy HIV I Infection | Phase 2 | 2024-01-04 |
| Active Not Recruiting | The Study of Immunization in People Living With HIV Undergoing an ATI for Elicitation of VRC01-lineage Antibod Chronic HIV Infection | Phase 1 | 2024-01-03 |
| Withdrawn | Broadly Neutralizing Antibodies 3BNC117-LS & 10-1074-LS to Prevent Relapse During ATI HIV Infections | Phase 1 | 2024-01-01 |
| Withdrawn | Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy Hepatitis B Virus | Phase 1 / Phase 2 | 2024-01-01 |
| Recruiting | Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation Kidney Transplant | Phase 2 | 2023-12-07 |
| Recruiting | Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus Tuberculous Meningitis | Phase 2 | 2023-12-07 |
| Withdrawn | Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) Ha CTLA4 Haploinsufficency, Chronic Cytopenia | Phase 1 / Phase 2 | 2023-11-30 |
| Completed | Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria Plasmodium Falciparum Infection | Phase 4 | 2023-11-29 |
| Completed | A Trial to Evaluate an HIV Envelope Trimer, N332-GT5 gp140, Adjuvanted With SMNP in Adult Participants Without HIV | Phase 1 | 2023-11-27 |
| Withdrawn | Evaluation and Follow-up of People With Tick-borne Diseases Lyme Disease, Tick-Borne Disease | — | 2023-11-13 |
| Recruiting | Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers Healthy | — | 2023-11-01 |
| Completed | Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge Model Influenza Infection | Phase 1 | 2023-10-23 |
| Recruiting | Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies Influenza, Respiratory Virus, Coronavirus | — | 2023-10-23 |
| Active Not Recruiting | A Study to Evaluate the Safety and Immunogenicity of Two Doses of DCVC H1 HA mRNA-LNP in Healthy Adults Influenza | Phase 1 | 2023-10-16 |
| Recruiting | Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resi Tuberculosis, Rifampicin Resistant Tuberculosis | Phase 1 | 2023-10-03 |
| Active Not Recruiting | Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vacc Epstein-Barr Virus Infection, Infectious Mononucleosis, Herpesvirus | Phase 1 / Phase 2 | 2023-09-22 |
| Completed | To Investigate Safety, Reactogenicity and Immunogenicity of VIR-1388 Compared With Placebo in Participants Wit HIV I Infection | Phase 1 | 2023-09-19 |
| Completed | Phase I Safety Study of B/HPIV3/S-6P Vaccine Via Nasal Spray in Adults SARS-CoV-2 Infection | Phase 1 | 2023-09-18 |
| Withdrawn | Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations Chronic Granulomatous Disease, Inflammatory Bowel Disease | — | 2023-09-08 |
| Completed | Effect of Bismuth Subsalicylate on the Gut Microbiome and Host Response in Healthy Adults Healthy Adults | Phase 1 | 2023-08-31 |
| Active Not Recruiting | Clinical Trial to Evaluate the Safety and Immunogenicity of Ferritin Nanoparticles Expressing Native-like HIV- Hiv | Phase 1 | 2023-08-29 |
| Completed | Trial to Evaluate the Safety, Tolerability, and Immunogenicity of a Mosaic Hexavalent Influenza Vaccine VRC-FL Influenza | Phase 1 | 2023-08-09 |
| Completed | Neonatal Phase 1 Valacyclovir Study Herpes Simplex | Phase 1 | 2023-08-07 |
| Completed | Study of the Plasmodium Vivax Transmission-blocking Vaccine Pvs230D1-EPA/Matrix-M to Assess Safety, Immunogeni Malaria | Phase 1 | 2023-08-04 |
| Active Not Recruiting | A Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral HIV-1 | Phase 1 | 2023-07-26 |
| Terminated | CD40L Antagonism in Rheumatoid Arthritis (RA) Rheumatoid Arthritis | Phase 2 | 2023-07-25 |
| Terminated | Transcutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIA Juvenile Idiopathic Arthritis (JIA) | Phase 2 | 2023-06-27 |
| Completed | Safety of Intravenous Apramycin in Adults Bacterial Infection | Phase 1 | 2023-06-16 |
| Completed | A Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living With HIV HIV-1-infection, Elevated Cardiovascular Risk | Phase 2 | 2023-05-30 |
| Recruiting | Daratumumab in Primary Antiphospholipid Syndrome Autoimmune Disorders | Phase 1 / Phase 2 | 2023-05-26 |
| Completed | L9LS MAb in Malian Adults Plasmodium Falciparum Infection, Malaria | Phase 2 | 2023-05-25 |
| Recruiting | Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adeni Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis | — | 2023-05-23 |
| Active Not Recruiting | Study of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants With Both Chronic Hepatitis B and HIV Hepatitis B, HIV Infections | Phase 2 | 2023-05-05 |
| Terminated | Siplizumab in T1DM Type 1 Diabetes Mellitus | Phase 1 / Phase 2 | 2023-04-26 |
| Completed | Screening of Volunteers for Clinical Trials of Investigational or Licensed Vaccines or Antiviral Products Vaccines, Antiviral Agents, Immunologic Factors | — | 2023-04-24 |
| Completed | Safety Study of Intravenous Ertapenem in Combination With Zidebactam (WCK 6777) Bacterial Infection | Phase 1 | 2023-04-19 |
| Completed | Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or HIV Infections | Phase 1 | 2023-04-10 |
| Completed | A Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding a Native-like HIV Env Tr HIV-1-infection | Phase 1 | 2023-04-05 |
| Completed | A Study to Evaluate the Safety and Immunogenicity of a Single Dose of H1ssF-3928 mRNA-LNP in Healthy Adults Influenza | Phase 1 | 2023-04-05 |
| Completed | Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC Monkeypox | Phase 4 | 2023-03-23 |
| Completed | A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine fo Monkeypox | Phase 2 | 2023-03-22 |
| Recruiting | Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Coun Herpes Zoster | Phase 1 / Phase 2 | 2023-03-13 |
| Recruiting | A Repository to Study Host-Microbiome Interactions in Health and Disease Healthy Controls, Pregnancy, Pediatric Illnesses | — | 2023-03-09 |
| Active Not Recruiting | Trial to Model Primary, Secondary, and Tertiary Dengue Using a Monovalent Vaccine Response To Dengue Exposure | Phase 1 | 2023-03-07 |
| Completed | COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study COVID-19, Kidney Transplant | Phase 2 | 2023-02-20 |
| Completed | A Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRCHIVMAB0115-00-AB (VRC01.23LS), A HIV | Phase 1 | 2023-01-30 |
| Completed | Evaluating the Safety and Immunogenicity of Stabilized CH505 TF chTrimer in Healthy, HIV-uninfected Adult Part HIV Infections | Phase 1 | 2023-01-23 |
| Recruiting | Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopath Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (Apeced), Alopecia Areata | Phase 2 | 2023-01-18 |
| Recruiting | Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis Multiple Sclerosis | Phase 4 | 2023-01-12 |
| Active Not Recruiting | Study to Assess the Use of JSP191 in Matched Unrelated Donor Transplantation for Chronic Granulomatous Disease Chronic Granulomatous Disease, CGD | EARLY_Phase 1 | 2023-01-02 |
| Withdrawn | The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel D Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis | — | 2022-12-09 |
| Terminated | Examining Distinct Immunophenotypes to Validate and Enhance Rational Treatment in Systemic Lupus Systemic Lupus Erythematosus | Phase 2 | 2022-11-30 |
| Withdrawn | Study to Evaluate the Effects of Cenicriviroc Mesylate on Arterial Inflammation in People Living With HIV HIV Infections | Phase 2 | 2022-11-22 |
| Completed | Longitudinal Endotyping Of Atopic Dermatitis Through Transcriptomic Skin Analysis Atopic Dermatitis | Phase 4 | 2022-11-21 |
| Completed | Phase 2 Shigella Vaccine and Challenge Immunisation, Shigella Infection | Phase 2 | 2022-10-12 |
| Completed | Tecovirimat for Treatment of Monkeypox Virus Monkeypox | Phase 2 | 2022-10-10 |
| Completed | A Study of the Safety, Tolerability, and Pharmacokinetics of Dolutegravir in Neonates Exposed to HIV-1 HIV | Phase 1 | 2022-10-05 |
| Completed | A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subj Bacterial Disease Carrier, Cystic Fibrosis | Phase 1 / Phase 2 | 2022-10-03 |
| Completed | Evaluation of Tofacitinib in Prevention of Photosensitivity in Lupus Cutaneous Lupus | Phase 1 | 2022-09-30 |
| Completed | Anti-malaria MAb in Kenyan Children Plasmodium Falciparum Infection, Malaria | Phase 2 | 2022-09-14 |
| Completed | Safety and Immunogenicity of CJCV2 With and Without ALFQ Campylobacter Infection | Phase 1 | 2022-09-13 |
| Completed | Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine Monkeypox | Phase 2 | 2022-09-09 |
| Terminated | Study of Tecovirimat for Human Mpox Virus MPOX | Phase 3 | 2022-09-08 |
| Completed | Natural History, Disease Progression, and Long-Term Neurologic Sequelae of Ebola Virus Disease (EVD) Survivors Ebola Virus Disease | — | 2022-08-25 |
| Active Not Recruiting | Trial to Evaluate the Safety and Immunogenicity of Priming Regimens of 426c.Mod.Core-C4b and Optional Boost Re HIV-1-infection | Phase 1 | 2022-08-22 |
| Completed | A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conju HIV | Phase 1 | 2022-08-15 |
| Enrolling By Invitation | Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease With Inflammatory Complications Chronic Granulomatous Disease, Inflammatory Gastrointestinal Disease, Inflammatory Skin Disease | Phase 1 / Phase 2 | 2022-08-12 |
| Active Not Recruiting | Linezolid Dosing Strategies in Drug-Resistant TB Tuberculosis, Multidrug-Resistant, Tuberculosis, Tuberculosis, Pulmonary | Phase 2 | 2022-08-11 |
| Recruiting | Respiratory Virus Sampling and Repository Influenza, COVID-19 | — | 2022-08-11 |
| Recruiting | Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis Chronic Granulomatous Disease-associated Colitis | Phase 1 / Phase 2 | 2022-08-08 |
| Recruiting | NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD) Chronic Granulomatous Disease, Infection | Phase 1 | 2022-07-22 |
| Terminated | Targeted Investigation of Microbiome Elimination Atopic Dermatitis | Phase 1 | 2022-07-18 |
| Completed | Dose Escalation, Open-Label Clinical Trial to Evaluate Safety, Tolerability and Immunogenicity of a Nipah Viru Nipah Virus Infection | Phase 1 | 2022-07-11 |
| Recruiting | Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab Chronic Granulomatous Disease | Phase 1 / Phase 2 | 2022-07-08 |
| Completed | Safety and Immunogenicity of BPL-1357, A BPL-Inactivated, Whole-Virus, Universal Influenza Vaccine Influenza | Phase 1 | 2022-06-27 |
| Completed | Anthrax AV7909 Liquid vs Lyophilized Anthrax, Anthrax Immunisation | Phase 1 | 2022-05-25 |
| Completed | Safety, Tolerability, and Immunogenicity Study of Sm-p80 + GLA-SE (SchistoShield(R)) Vaccine in Healthy Adults Schistosomiasis | Phase 1 | 2022-05-23 |
| Recruiting | VIBRANT: VIB4920 for Active Lupus Nephritis Lupus Nephritis | Phase 2 | 2022-05-16 |
| Active Not Recruiting | Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents Asthma | Phase 2 | 2022-05-04 |
| Terminated | A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficien HIV Infections, Cytomegalovirus, CMV | Phase 2 | 2022-04-19 |
| Recruiting | Registry of Asthma Characterization and Recruitment 3 (RACR3) Asthma | — | 2022-04-15 |
| Completed | COVID-19 Variant Immunologic Landscape Trial (COVAIL Trial) COVID-19 | Phase 2 | 2022-03-30 |
| Active Not Recruiting | Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350-Ferritin Nanoparticle Vaccine in Healthy Adults EBV, Epstein-Barr Virus Infection, Infectious Mononucleosis | Phase 1 | 2022-03-29 |
| Completed | Phase I Norovirus Challenge Model Gastroenteritis Norovirus | Phase 1 | 2022-03-28 |
| Completed | A Phase 1 Trial to Evaluate CAP256V2LS in Healthy Adults HIV | Phase 1 | 2022-03-22 |
| Completed | Anti-malaria MAb in Malian Children Plasmodium Falciparum Infection, Malaria | Phase 2 | 2022-03-18 |
| Completed | Evaluating the Infectivity, Safety and Immunogenicity of a Recombinant Live-Attenuated Respiratory Syncytial V RSV Infection | Phase 1 | 2022-03-16 |
| Completed | Community Dynamics of Malaria Transmission in Humans and Mosquitoes at Maferinyah Sub-Prefecture, Guinea Malaria | — | 2022-03-07 |
| Withdrawn | Evaluating the Safety and Immunogenicity of a Prime-boost Vaccine Regimen of GEO-D02 DNA and MVA/HIV62B With a HIV Infections | Phase 1 | 2022-03-01 |
| Recruiting | Human Immune Response to Ixodes Scapularis Tick Bites Tick-borne Diseases, Tick Resistance, Lyme Disease | Phase 1 / Phase 2 | 2022-02-28 |
| Withdrawn | Pathogenesis of BTK-mediated Hyper-Inflammatory Responses in COVID-19 (RESPOND) COVID-19 | — | 2022-02-17 |
| Completed | Evaluation of Two Zika Viruses for Use in Controlled Human Infection Models (CHIM) Zika Virus | Phase 1 | 2022-02-16 |
| Completed | Blood-Stage Plasmodium Vivax Cell Bank Malaria | Phase 1 | 2022-02-15 |
| Active Not Recruiting | A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39 HIV Infections | Phase 1 | 2022-02-11 |
| Completed | An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 Challenge Dengue | Phase 2 | 2022-02-03 |
| Withdrawn | Selective CD28 Blockade in Renal Transplant Recipients Kidney Transplantation, Renal Transplant Recipients | Phase 2 | 2022-01-10 |
| Active Not Recruiting | Carfilzomib and Belatacept for Desensitization Highly Sensitized Prospective Kidney Transplant Recipients | Phase 1 / Phase 2 | 2021-12-28 |
| Completed | COVID Protection After Transplant-Immunosuppression Reduction Kidney Transplant Recipients, Liver Transplant Recipients | Phase 2 | 2021-12-06 |
| Recruiting | Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune) Human Papillomavirus | — | 2021-11-17 |
| Completed | Empagliflozin as a Treatment for Severe Congenital Neutropenia Due to G6PC3 Deficiency Crohn's Disease, Glycogen Metabolism, Inflammatory Bowel Disease (IBD) | Phase 1 | 2021-11-16 |
| Completed | A Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of PGDM1400LS Alone and in Combina HIV Infections | Phase 1 | 2021-11-15 |
| Terminated | Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CL HIV, Tuberculosis | Phase 2 | 2021-11-05 |
| Completed | Trial to Evaluate the Safety and Immunogenicity of a Modified Vaccinia Ankara (MVA)-Based Anti-Cytomegalovirus Cytomegalovirus Infections, HIV Infections, Vaccine | Phase 2 | 2021-11-02 |
| Active Not Recruiting | Daratumumab and Belatacept for Desensitization Highly Sensitized Prospective Kidney Transplant Recipients | Phase 1 / Phase 2 | 2021-11-01 |
| Completed | Mucosal Immunity Against Neisseria Gonorrhoeae After 4CMenB Vaccination Gonorrhoea | Phase 2 | 2021-11-01 |
| Completed | Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali Malaria,Falciparum | Phase 1 | 2021-10-22 |
| Recruiting | Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases COVID-19, Vaccination, Healthy Volunteer | — | 2021-10-13 |
| Terminated | Elotuzumab in Immunoglobulin G4-Related Disease (IgG4-RD) IgG4 Related Disease, IgG4-RD | Phase 2 | 2021-10-13 |
| Active Not Recruiting | Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District Malaria | — | 2021-09-30 |
| Completed | Natural History of Systemic and Nasal Mucosal Immunity After Influenza Vaccination in a Pediatric Population Influenza Immunity | — | 2021-09-24 |
| Withdrawn | Defining the COVID-19 Immunity Denominator in the Mekong: a Cross-Sectional Seroprevalence Study of SARS-CoV-2 Healthy Volunteers | — | 2021-09-24 |
| Terminated | PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) COVID-19 | Phase 3 | 2021-09-15 |
| Completed | Trial to Evaluate L9LS in Healthy Adults Malaria | Phase 1 | 2021-09-13 |
| Terminated | Assess the Safety and Immunogenicity of One or Two Doses of Sing2016 M2SR H3N2 Influenza Vaccine H3N2 Influenza | Phase 1 | 2021-09-10 |
| Completed | The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Systemic Allergic Reaction | Phase 2 | 2021-09-08 |
| Completed | Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum HIV Infections, Tuberculosis | — | 2021-09-01 |
| Completed | Vaccination for Recovered Inpatients With COVID-19 (VATICO) Covid19 | Phase 4 | 2021-08-25 |
| Recruiting | Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination Influenza, COVID-19 | — | 2021-08-19 |
| Completed | Influenza Challenge Study to Determine the Optimal Infection Dose and Safety of a Recombinant H3N2 (A/Texas/71 Influenza | Phase 1 | 2021-08-19 |
| Completed | International Study on COVID-19 Vaccine to Assess Immunogenicity, Reactogenicity and Efficacy (InVITE) COVID-19 | — | 2021-08-16 |
| Terminated | COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Pemphigus Vulgaris | Phase 2 | 2021-08-13 |
| Completed | COVID-19 Protection After Transplant Pilot Study Kidney Transplant Recipients | Phase 2 | 2021-08-10 |
| Recruiting | Metabolic Profiling of Immune Responses in Immune-mediated Diseases Primary Immunodeficiency, Psoriasis, Atopic Dermatitis | — | 2021-08-10 |
| Completed | ACTIV-5 / Big Effect Trial (BET-C) for the Treatment of COVID-19 COVID-19 | Phase 2 | 2021-08-03 |
| Active Not Recruiting | PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Tuberculosis, HIV | — | 2021-07-27 |
| Completed | SARS-CoV-2 Immune Responses After COVID-19 Therapy and Subsequent Vaccine Covid19, SARS-CoV2 Infection | Phase 4 | 2021-07-09 |
| Completed | Molecular Basis of Erythrocyte Invasion by Plasmodium Vivax Into Duffy-Negative Erythrocytes in Mali Malaria | — | 2021-06-30 |
| Completed | Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease Chronic Granulomatous Disease, Inflammatory Bowel Disease | Phase 2 | 2021-06-23 |
| Completed | MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) COVID-19 | Phase 3 | 2021-06-11 |
| Completed | Malaria Transmission in Humans and Mosquitoes at the Area of Sabou, Burkina Faso Malaria | — | 2021-06-10 |
| Active Not Recruiting | The Effect of Helminth Infection Plus COVID-19 Infection on the Immune Response and Intestinal Microorganisms COVID-19 | — | 2021-06-01 |
| Completed | Delayed Heterologous SARS-CoV-2 Vaccine Dosing (Boost) After Receipt of EUA Vaccines COVID-19 | Phase 1 / Phase 2 | 2021-05-28 |
| Completed | First-in-Human Clinical Trial of a Mosaic Quadrivalent Influenza Vaccine Compared With a Licensed Inactivated Influenza, Seasonal Influenza | Phase 1 | 2021-05-24 |
| Active Not Recruiting | Safety, Tolerability, and Efficacy of IL-15 Superagonist (N-803) With and Without Combination Broadly Neutrali HIV Infection | Phase 1 | 2021-05-21 |
| Completed | DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia Staphylococcal Bacteraemia | Phase 2 | 2021-04-22 |
| Terminated | Liver Transplantation With Tregs at UCSF Liver Transplant | Phase 1 / Phase 2 | 2021-04-22 |
| Completed | ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19 Covid19 | Phase 3 | 2021-04-20 |
| Completed | Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial) Covid19 | Phase 3 | 2021-04-20 |
| Completed | COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations Immunodeficiencies, Immune Dysregulations | — | 2021-04-20 |
| Completed | Remdesivir for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial) Covid19 | Phase 3 | 2021-04-20 |
| Completed | The Influence of Malnutrition, Diabetes Mellitus, and Helminth Infections on Biosignatures in Latent Tuberculo Mycobacterium Tuberculosis, LTBI (Latent TB Infection), Malnutrition | — | 2021-04-19 |
| Completed | SARS-COV2 Pandemic Serosurvey in a Rare Disease Population SARS-COV2 Virus | — | 2021-04-19 |
| Terminated | COVID-19 and Anti-CD14 Treatment Trial Coronavirus Disease 2019 (COVID-19), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Phase 2 | 2021-04-12 |
| Completed | COVID19 SARS Vaccinations: Systemic Allergic Reactions to SARS-CoV-2 Vaccinations SARS-CoV Infection, COVID-19, Allergic Reaction | Phase 2 | 2021-04-07 |
| Completed | Safety and Immunogenicity Study of a SARS-CoV-2 (COVID-19) Variant Vaccine (mRNA-1273.351) in Naïve and Previo COVID-19, COVID-19 Immunisation | Phase 1 | 2021-03-31 |
| Completed | PK and Safety of Remdesivir for Treatment of COVID-19 in Pregnant and Non-Pregnant Women in the US COVID-19 | — | 2021-03-31 |
| Completed | Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy COVID-19 | Phase 1 | 2021-03-25 |
| Completed | A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 Vacc SARS-CoV-2 Infection | Phase 3 | 2021-03-24 |
| Active Not Recruiting | Systems Biology of Early Atopy Allergic Diseases, Food Allergy, Atopic Dermatitis | — | 2021-03-18 |
| Completed | A Study to Assess the Safety and Immune Response to Env-C DNA and Protein Vaccines in Kenya HIV Infections | Phase 1 | 2021-03-15 |
| Terminated | Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals HIV Infection, LTBI | Phase 2 | 2021-02-27 |
| Completed | Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistan HIV Infections, Non-Alcoholic Fatty Liver Disease | Phase 2 | 2021-02-19 |
| Completed | Safety and Efficacy of CIS43LS Anti-malaria mAb in Mali Plasmodium Falciparum Infection, Malaria | Phase 2 | 2021-02-15 |
| Completed | AZD7442 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) COVID-19 | Phase 3 | 2021-02-10 |
| Completed | Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia Dengue Fever, Zika, Vector-Borne Diseases | — | 2021-02-08 |
| Terminated | Mepolizumab in Episodic Angioedema With Eosinophilia Eosinophilia, Angioedema | Phase 2 | 2021-01-14 |
| Active Not Recruiting | Safety and Efficacy Study of Meningococcal Group B Vaccine rMenB+OMV NZ (Bexsero) to Prevent Gonococcal Infect Gonococcal Infection | Phase 2 | 2020-12-29 |
| Completed | VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) COVID-19 | Phase 3 | 2020-12-16 |
| Completed | BRII-196/BRII-198 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) COVID-19 | Phase 3 | 2020-12-16 |
| Completed | B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B HIV Infection, Hepatitis B | Phase 3 | 2020-12-14 |
| Completed | Evaluation of AMG 714 for Vitiligo Vitiligo | Phase 2 | 2020-12-11 |
| Completed | Prevalence and Incidence of Lassa Virus Infection in Southern Mali Lassa Virus Infection | — | 2020-12-04 |
| Completed | Adaptive COVID-19 Treatment Trial 4 (ACTT-4) COVID-19 | Phase 3 | 2020-12-02 |
| Completed | COVID-19: Pediatric Research Immune Network on SARS-CoV-2 and MIS-C Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Multisystem Inflammatory Syndrome in Children (MIS-C), Coronavirus Disease 2019 (COVID-19) | — | 2020-11-19 |
| Completed | Sample Collection for Systems Evaluation of Patients With Unknown or Incompletely Characterized Immune Defects Immunodeficiency | — | 2020-11-12 |
| Completed | Evaluating the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of the Monoclonal Antibody PGT12 HIV Infections | Phase 1 | 2020-11-10 |
| Completed | Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction Allergic Rhinoconjunctivitis, Grass Pollen Allergy | Phase 2 | 2020-11-09 |
| Completed | Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Ad HIV Infections | Phase 2 | 2020-11-04 |
| Completed | Characterization of Skin Immunity to Aedes Aegypti Saliva in Dengue-endemic Participants in Cambodia Vector Borne Diseases | Phase 1 | 2020-10-27 |
| Completed | A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults Tuberculosis | Phase 2 | 2020-10-27 |
| Completed | ACTIV-5 / Big Effect Trial (BET-A) for the Treatment of COVID-19 COVID-19 | Phase 2 | 2020-10-23 |
| Completed | ACTIV-5 / Big Effect Trial (BET-B) for the Treatment of COVID-19 COVID-19 | Phase 2 | 2020-10-23 |
| Completed | Phase 1 Study of SAR440894 vs Placebo Chikungunya Virus Infection | Phase 1 | 2020-10-14 |
| Recruiting | Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVI COVID-19 Infection | — | 2020-10-13 |
| Completed | Dose, Safety, Tolerability and Immunogenicity of an Influenza H10 Stabilized Stem Ferritin Vaccine, VRC-FLUNPF Influenza | Phase 1 | 2020-10-08 |
| Completed | Safety and Pharmacokinetics of VT-1598 Coccidioidomycosis | Phase 1 | 2020-09-29 |
| Completed | Safety and Drug Detection Study of Dapivirine Vaginal Ring and Oral TRUVADA® in Breastfeeding Mother-Infant Pa HIV Infections | Phase 3 | 2020-09-24 |
| Completed | The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate R HIV Infections | Phase 1 / Phase 2 | 2020-09-09 |
| Completed | A Cluster-randomized Trial to EValuate the Efficacy of Wolbachia-InfecTed Aedes Aegypti Mosquitoes in Reducing Dengue Fever | N/A | 2020-09-09 |
| Completed | SARS-COV2 Pandemic Serosurvey and Blood Sampling SARS-COV2 Virus | — | 2020-08-26 |
| Completed | ACTIV-2: A Study for Outpatients With COVID-19 Coronavirus, Covid19 | Phase 2 / Phase 3 | 2020-08-19 |
| Completed | Adaptive COVID-19 Treatment Trial 3 (ACTT-3) COVID-19 | Phase 3 | 2020-08-05 |
| Completed | LY3819253 (LY-CoV555) for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) COVID-19 | Phase 3 | 2020-08-05 |
| Completed | ACTIV-3: Therapeutics for Inpatients With COVID-19 Covid19 | Phase 3 | 2020-08-04 |
| Completed | Malaria Prevalence Around Maferinyah, Guinea Malaria | — | 2020-07-13 |
| Completed | Surveillance of Individuals Following SARS-CoV-2 Infection COVID-19 | — | 2020-07-07 |
| Active Not Recruiting | A Longitudinal Study of COVID-19 Sequelae and Immunity COVID-19 | — | 2020-06-17 |
| Completed | Collection of Anti-SARS-CoV-2 Immune Plasma Coronavirus Disease 2019 (COVID-19) | — | 2020-06-01 |
| Completed | COVID-19 Associated Lymphopenia Pathogenesis Study in Blood Coronavirus Disease 2019 | — | 2020-05-22 |
| Terminated | Evaluating the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons COVID-19, SARS-CoV 2 | Phase 2 | 2020-05-13 |
| Completed | Adaptive COVID-19 Treatment Trial 2 (ACTT-2) COVID-19 | Phase 3 | 2020-05-08 |
| Completed | Immunophenotyping Assessment in a COVID-19 Cohort Coronavirus Disease 2019 (COVID-19), SARS-CoV-2 | — | 2020-05-01 |
| Completed | COVID-19: Human Epidemiology and Response to SARS-CoV-2 Coronavirus Disease 2019 (COVID-19), SARS-CoV-2 | — | 2020-05-01 |
| Completed | Safety and Immunogenicity Study of 2019-nCoV Vaccine (mRNA-1273) for Prophylaxis of SARS-CoV-2 Infection (COVI COVID-19, COVID-19 Immunisation | Phase 1 | 2020-03-16 |
| Withdrawn | Glutamine Supplementation in People With Immune Dysregulation Eczema, MTOROC1 Signaling | EARLY_Phase 1 | 2020-03-12 |
| Recruiting | Belimumab With Rituximab for Primary Membranous Nephropathy Membranous Nephropathy, Nephrotic Syndrome | Phase 2 | 2020-03-06 |
| Completed | StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberc Tuberculosis, Pulmonary Tuberculosis | Phase 2 | 2020-02-21 |
| Completed | Adaptive COVID-19 Treatment Trial (ACTT) COVID-19 | Phase 3 | 2020-02-21 |
| Completed | Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Ad HIV Infections | Phase 2 | 2020-02-19 |
| Completed | Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants HIV Infections | Phase 1 | 2020-01-13 |
| Recruiting | Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe) Idiopathic CD4 Lymphopenia | Phase 1 | 2020-01-13 |
| Completed | Randomized, Open Label Safety Trial of Dapivirine Vaginal Ring and Oral TRUVADA® Use in Pregnancy HIV Infections | Phase 3 | 2020-01-09 |
| Completed | Trial to Evaluate CIS43LS in Healthy Adults Malaria | Phase 1 | 2020-01-07 |
| Completed | Long-Acting Cabotegravir Plus VRC-HIVMAB075-00-AB (VRC07-523LS) for Viral Suppression in Adults Living With HI HIV Infections | Phase 2 | 2019-12-31 |
| Recruiting | Paradoxical Tuberculosis Reactions in Patients Without HIV Infection Tuberculosis | — | 2019-12-20 |
| Recruiting | Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS) Relapsing Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis | Phase 3 | 2019-12-19 |
| Completed | Safety and Pharmacokinetic Study of Tenofovir Alafenamide (TAF)/Elvitegravir (EVG) Administered Rectally HIV Infections | Phase 1 | 2019-12-11 |
| Completed | Treg Modulation With CD28 and IL-6 Receptor Antagonists Living-Donor Kidney Transplant, Kidney Transplant Recipients | Phase 1 / Phase 2 | 2019-12-11 |
| Terminated | Safety and Pharmacokinetics of Rezafungin Fungal Infection | Phase 1 | 2019-12-04 |
| Active Not Recruiting | Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and Chronic Granulomatous Disease | EARLY_Phase 1 | 2019-10-28 |
| Completed | H1N1v Virus Challenge Study in Healthy Subjects Influenza | Phase 1 | 2019-10-22 |
| Completed | Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine Healthy Volunteer | Phase 2 | 2019-10-02 |
| Completed | Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia Malaria | — | 2019-10-01 |
| Recruiting | Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants Alpha and Beta Thalassemia, Sickle Cell Disease, Malaria | — | 2019-09-25 |
| Completed | Dosage-Escalation Study of the Safety and Immunogenicity of a Novel Rabies Vaccine ChAd155-RG vs. the Comparat Rabies, Rabies Immunisation | Phase 1 | 2019-09-19 |
| Terminated | Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Loiasis | Phase 2 | 2019-09-16 |
| Completed | Suppression Of Bacterial Vaginosis (BV) [SUBVert] Bacterial Vaginosis | Phase 2 | 2019-09-09 |
| Completed | Evaluating the Safety and Immunogenicity of an HIV-1 gp41 MPER-656 Liposome Vaccine in Healthy, HIV-uninfected HIV Infections | Phase 1 | 2019-08-26 |
| Completed | PREVAIL VIII: A CoHOrt Clinical, Viral, and ImmuNOlogic Monitoring Study of People Living With Retroviral Infe HIV | — | 2019-08-22 |
| Terminated | Asymptomatic Congenital CMV Treatment Congenital Cytomegalovirus Infection | Phase 2 | 2019-08-21 |
| Terminated | Safety and Immunotherapeutic Activity of an Anti-PD-1 Antibody (Cemiplimab) in Participants With HIV-1 on Supp HIV Infections | Phase 1 / Phase 2 | 2019-08-13 |
| Recruiting | Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing Vector-Borne Diseases, Emerging Pathogens | — | 2019-07-23 |
| Completed | Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen OIT in Food Allergic Participants Peanut Allergy, Multi-food Allergy | Phase 3 | 2019-07-22 |
| Recruiting | Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies Primary Immunodeficiency | — | 2019-07-22 |
| Completed | Evaluating the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Combinations of Monoclonal An HIV Infections | Phase 1 | 2019-07-17 |
| Completed | A Trial to Evaluate the Pharmacokinetics and Safety of AVYCAZ(R) in Combination With Aztreonam Bacterial Infection | Phase 1 / Phase 2 | 2019-07-09 |
| Completed | Evaluating the Safety and Immunogenicity of AGS-v PLUS, a Universal Mosquito-Borne Disease and Mosquito Contro Mosquito-Borne Infectious Diseases | Phase 1 | 2019-07-08 |
| Completed | Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites Malaria | Phase 2 | 2019-07-03 |
| Completed | Ebola Sudan Chimpanzee Adenovirus Vector Vaccine in Healthy Adults Ebola Virus | Phase 1 | 2019-07-02 |
| Completed | Intravenous Fosfomycin Pharmacokinetics Study Bacterial Infection, Multiple-drug Resistance, Pathogen Resistance | Phase 1 | 2019-06-27 |
| Terminated | Safety and Immunogenicity of a Single Dose of the Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV Respiratory Syncytial Virus (RSV) | Phase 1 / Phase 2 | 2019-06-20 |
| Completed | Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemi Indolent Systemic Mastocytosis | Phase 2 | 2019-06-19 |
| Completed | Dual bNAb Treatment in Children HIV Infection | Phase 1 / Phase 2 | 2019-06-17 |
| Completed | Flublok or Fluzone With Advax-CpG55.2 or AF03 Influenza, Influenza Immunisation | Phase 1 | 2019-06-10 |
| Active Not Recruiting | Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients Tuberculosis, MDR | Phase 3 | 2019-06-03 |
| Completed | A Clinical Trial in Healthy, HIV-1-Uninfected Adult Participants to Compare the Safety, Tolerability and Immun HIV Infections | Phase 1 | 2019-05-23 |
| Completed | Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): Malaria | Phase 1 / Phase 2 | 2019-05-23 |
| Terminated | Pharmacokinetics and Safety of SAR441236 HIV-1-infection | Phase 1 | 2019-05-20 |
| Completed | Dried Blood Spot Testing of CMV Detection in HCT Recipients Cytomegalovirus Infection | N/A | 2019-05-03 |
| Completed | Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenz Influenza | Phase 2 | 2019-04-29 |
| Completed | Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escala Malaria | Phase 2 | 2019-04-24 |
| Recruiting | Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in People With Elevated Total Serum Milk and/or Peanut Allergy | Phase 2 | 2019-04-19 |
| Recruiting | Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers Healthy Volunteer | Phase 1 | 2019-04-17 |
| Completed | Safety Study of Hepatitis E Vaccine (HEV239) Hepatitis E, Immunisation | Phase 1 | 2019-04-12 |
| Terminated | Combination Therapy With VRC01 and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interru HIV | Phase 1 | 2019-04-04 |
| Completed | More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirin HIV Infections | Phase 1 / Phase 2 | 2019-04-03 |
| Completed | VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults Venezuelan Equine Encephalitis, Western Equine Encephalitis, Eastern Equine Encephalitis | Phase 1 | 2019-04-02 |
| Completed | Dose, Safety, Tolerability and Immunogenicity of an Influenza H1 Stabilized Stem Ferritin Vaccine in Healthy A Influenza Infection | Phase 1 | 2019-04-01 |
| Active Not Recruiting | Liver Transplantation With Tregs at MGH Liver Transplant | Phase 1 / Phase 2 | 2019-03-29 |
| Active Not Recruiting | The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE HIV Infections | Phase 3 | 2019-03-28 |
| Completed | HIV-1-Gag Conserved-Element DNA Vaccine (p24CE) Vaccine Study HIV Infections | Phase 1 / Phase 2 | 2019-03-26 |
| Terminated | A Double-Blind Placebo-Control Dose Escalating Study to Evaluate the Safety and Immunogenicity of dmLT by Oral Gastroenteritis Escherichia Coli, Immunisation | Phase 1 | 2019-03-10 |
| Completed | Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Human Immunodeficiency Virus Prevention, Human Immunodeficiency Virus (HIV) | Phase 1 | 2019-03-07 |
| Completed | Clinical Study of a Diagnostic Device for NG, TV and CT in Women Chlamydial Infection, Gonococcal Infection, Trichomoniasis | N/A | 2019-02-27 |
| Completed | Andes Virus DNA Vaccine for the Prevention of Hantavirus Pulmonary Syndrome Using the PharmaJet Stratis(R) Nee Hantavirus Pulmonary Infection, Immunisation | Phase 1 | 2019-02-19 |
| Completed | An Observational Study to Assess the Prevalence and Outcomes of Primary Pulmonary Coccidioidomycosis in Person Coccidioidomycosis, Pneumonia | — | 2019-02-14 |
| Active Not Recruiting | Immunogenicity of the 9-Valent Human Papillomavirus Recombinant Vaccine in People With Idiopathic CD4 T Cell L Idiopathic CD4 T Cell Lymphocytopenia | Phase 2 | 2019-02-04 |
| Completed | Study on the Safety and Immunogenicity of Boostrix Vaccine in Pregnant Malian Women and Their Infants Clostridium Difficile Immunisation, Diphtheria, Diphtheria Immunisation | Phase 2 | 2019-01-24 |
| Completed | Evaluating the Safety and Pharmacokinetics of VRC07-523LS in the Sera and Mucosae of Healthy, HIV-Uninfected A HIV Infections | Phase 1 | 2019-01-18 |
| Completed | Evaluating the Safety of and Adherence to a Vaginal Matrix Ring Containing Dapivirine and Oral Emtricitabine/T HIV Infections | Phase 2 | 2019-01-14 |
| Terminated | Safety and Efficacy of FMT in Individuals With One or More Recurrences of Clostridium Difficile Associated Dis Clostridial Infection, Dysbiosis, Probiotic Therapy | Phase 1 / Phase 2 | 2019-01-11 |
| Completed | Immunogenicity and Safety Study of Inactivated Subunit H5N1 Influenza Vaccine in Prior Recipients of Live Atte Influenza | Phase 1 | 2019-01-08 |
| Completed | Retrospective Chart Review of Candida Fungemia Candida Fungemia | — | 2019-01-03 |
| Completed | Pharmacokinetic and Safety Study of a 90 Day Intravaginal Ring Containing Tenofovir HIV Infections | Phase 1 | 2019-01-02 |
| Withdrawn | Evaluating the Safety and Immunogenicity of the IHV01 Protein Vaccine Primed and Co-Administered With HIV DNA HIV Infections | Phase 1 | 2019-01-01 |
| Completed | rCSP/AP10-602 [GLA-LSQ] Vaccine Trial Plasmodium Falciparum Infection | Phase 1 | 2018-12-21 |
| Completed | Tocilizumab in Cardiac Transplantation Heart Transplant | Phase 2 | 2018-12-20 |
| Completed | Evaluating HIV-1 Neutralization Antibody Breadth in Response to HIV gp120 Protein Vaccine in HIV-uninfected Ad HIV Infections, Systemic Lupus Erythematosus | Phase 1 | 2018-12-19 |
| Completed | 2017 A/H7N9 IIV Revaccination Avian Influenza, Influenza Immunisation | Phase 2 | 2018-12-18 |
| Active Not Recruiting | Vaginal Microbiome Exposure and Immune Responses in C-section Infants Allergic Diseases, Asthma | EARLY_Phase 1 | 2018-11-28 |
| Completed | Investigational Therapeutics for the Treatment of People With Ebola Virus Disease Ebola Virus | Phase 2 / Phase 3 | 2018-11-21 |
| Completed | A Trial to Evaluate the Safety and Systems Biology Response of Ebolavirus Zaire Vaccine (ChAd3-EBO-Z) Ebola Disease, Immunisation | Phase 1 | 2018-11-12 |
| Terminated | Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes ( Urinary Tract Infection | Phase 4 | 2018-11-07 |
| Completed | Safety/Efficacy Study of Seqirus A/H7N9 IIV With or Without MF59(R) Adjuvant to Prevent Avian Influenza Avian Influenza, Influenza Immunisation | Phase 2 | 2018-11-02 |
| Completed | Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Witho Syphilis | Phase 4 | 2018-10-31 |
| Completed | Safety and Immunogenicity of Intranasal BPZE1 Vaccination in Healthy Adults Pertussis, Pertussis Immunisation | Phase 2 | 2018-10-23 |
| Completed | NNITS-Nitazoxanide for Norovirus in Transplant Patients Study Gastroenteritis Norovirus | Phase 2 | 2018-10-15 |
| Completed | cAd3-Marburg Vaccine in Healthy Adults Marburg Virus Disease | Phase 1 | 2018-10-09 |
| Completed | Development of Childhood Anti-Influenza Immunity Influenza, Influenza Immunisation | Phase 4 | 2018-09-25 |
| Completed | Thorough QT/QTC (TQT) Clinical Trial to Evaluate the Effect of Zoliflodacin on Cardiac Repolarization in Healt Electrocardiogram Repolarisation Abnormality, Gonococcal Infection | Phase 1 | 2018-09-25 |
| Completed | A Study to Evaluate the Safety and Pharmacokinetics of NTM-1633 vs Placebo Administered Intravenously in Healt Botulism | Phase 1 | 2018-09-25 |
| Terminated | Combination Therapy With 3BNC117 and 10-1074 in HIV-Infected Individuals HIV | Phase 1 | 2018-09-10 |
| Completed | Defining Skin Immunity of a Bite of Key Insect Vectors in Humans Zika, Dengue, Malaria | N/A | 2018-09-05 |
| Completed | 2013/2017 H7N9 Prime-Boost Interval Avian Influenza, Influenza Immunisation | Phase 2 | 2018-08-21 |
| Completed | H3N2 M2SR in Pediatric Population Influenza, Influenza Immunisation | Phase 1 | 2018-08-15 |
| Terminated | A Single Dose of Pembrolizumab in HIV-Infected People Human Immunodeficiency Virus | Phase 1 | 2018-08-06 |
| Completed | Evaluating the Safety and Antiviral Activity of Monoclonal Antibody VRC01 in Infants With HIV Receiving Combin HIV Infections | Phase 1 / Phase 2 | 2018-08-06 |
| Terminated | Safety and Pharmacokinetics Study of DM1157 to Treat Malaria Malaria | Phase 1 | 2018-07-31 |
| Completed | Inpatient Challenge Study of rRSV A/Maryland/001/11, a Human Respiratory Syncytial Virus Challenge Strain, Adm Respiratory Syncytial Virus Infections | Phase 1 | 2018-07-31 |
| Completed | Tolerance by Engaging Antigen During Cellular Homeostasis Kidney Transplantation, Renal Transplantation, Renal Transplant Recipient | Phase 1 | 2018-07-30 |
| Terminated | Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis Atopic Dermatitis (AD) | Phase 4 | 2018-07-25 |
| Completed | Cockroach Immunotherapy in Children and Adolescents Persistent Asthma | Phase 2 | 2018-07-16 |
| Completed | Trial of Azithromycin vs. Doxycycline for the Treatment of Rectal Chlamydia in MSM Anal Chlamydia Infection | Phase 4 | 2018-07-13 |
| Terminated | Phase I Study to Evaluate a Human Monoclonal Antibody (MAb) 10E8VLS Administered Alone or Concurrently With MA Healthy Adult Immune Response | Phase 1 | 2018-07-10 |
| Terminated | Clinical Study of a Single-Use, Point-of-Care Molecular Diagnostic Device for the Detection of Neisseria Gonor Chlamydial Infection, Gonorrhoea, Trichomoniasis | N/A | 2018-07-09 |
| Completed | Safety and Immunogenicity of the Live Attenuated Zika Vaccine rZIKV/D4Δ30-713 in Flavivirus-naïve Adults Zika Virus | Phase 1 | 2018-07-06 |
| Completed | Follow up of LEAP Participants and Their Families Peanut Allergy | — | 2018-07-05 |
| Completed | Evaluating the Pharmacokinetics, Feasibility, Acceptability, and Safety of Oral Pre-Exposure Prophylaxis for H HIV Infections | Phase 2 | 2018-07-03 |
| Completed | Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Te HIV Infections | Phase 1 / Phase 2 | 2018-07-02 |
| Completed | Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients With Leukocyte Adhesion Deficiency Type 1 (LAD1 LAD1 | Phase 1 / Phase 2 | 2018-07-02 |
| Recruiting | Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates. Cesarean Delivery Affecting Newborn, Obesity, Childhood, Intestinal Microbiome | Phase 1 / Phase 2 | 2018-07-01 |
| Completed | Investigating Vector-Borne Determinants of Aedes Transmitted Arboviral Infections in Cambodia: An Observationa Dengue Fever | — | 2018-07-01 |
| Completed | Evaluating the Infectivity, Safety and Immunogenicity of Respiratory Syncytial Virus Vaccines, RSV 6120/∆NS1 a RSV Infection | Phase 1 | 2018-06-29 |
| Recruiting | Sample Collection From Healthy Volunteers for Assay Optimization Healthy Volunteers | — | 2018-06-28 |
| Completed | Phase I, Open-Label, Dose-Escalation Study of a Human Monoclonal Antibody, VRC-HIVMAB091-00-AB (N6LS), Adminis HIV Antibodies | Phase 1 | 2018-06-21 |
| Completed | Evaluating the Safety and Pharmacokinetics of PC-1005 Administered Rectally to HIV-1 Seronegative Adults HIV Infections | Phase 1 | 2018-06-19 |
| Completed | Herpesviruses Reactivation In Hiv-Infected Women Initiating ART (HERA) Herpes Virus-Related Illnesses | — | 2018-06-15 |
| Completed | H5N1 With or Without Topical Aldara in Healthy Adults Avian Influenza, Influenza Immunisation | Phase 1 | 2018-06-13 |
| Recruiting | The Mechanistic Biology of Primary Immunodeficiency Disorders Primary Immunodeficiency Disorders | — | 2018-05-30 |
| Completed | A Phase Ib Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel)(R) With or Without Schistosomiasis | Phase 1 | 2018-05-20 |
| Completed | Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-EBOMAB092-00-AB (MAb114), Administered Intrave Healthy Adult Immune Responses to Vaccine | Phase 1 | 2018-05-16 |
| Completed | A Safety and Immunogenicity Study of Intranasal Sendai Virus Vectored Respiratory Syncytial Virus (SeVRSV) Vac Antiviral Prophylaxis, Respiratory Syncytial Virus Infection | Phase 1 | 2018-05-16 |
| Completed | Safety, Immunogenicity, and Protective Efficacy of Two Regimens of Radiation Attenuated Plasmodium Falciparum Malaria | Phase 1 | 2018-05-14 |
| Completed | Pharmacokinetic Study of Dapivirine Gel Administered Rectally to HIV-1 Seronegative Adults HIV Infections | Phase 1 | 2018-05-10 |
| Terminated | 2-5 Intermittent Caloric Restriction in HIV Human Immunodeficiency Virus, Metabolic Syndrome | N/A | 2018-05-09 |
| Completed | Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase HIV Infections | Phase 2 | 2018-04-26 |
| Completed | Two Doses of Multimeric-001 (M-001) Followed by Influenza Vaccine Influenza, Influenza Immunisation | Phase 2 | 2018-04-09 |
| Terminated | Pretomanid in Adults With Hepatic Impairment Tuberculosis | Phase 1 | 2018-03-29 |
| Completed | Minocycline Pharmacokinetics (ACUMIN) Bacterial Infection | Phase 4 | 2018-03-28 |
| Completed | Evaluating the Safety and Immunogenicity of Env (A,B,C,A/E)/Gag (C) DNA and gp120 (A,B,C,A/E) Protein/GLA-SE H HIV Infections | Phase 1 | 2018-03-16 |
| Terminated | Evaluating the Live-Attenuated Human Parainfluenza Virus Type 3 Vectored Vaccine Candidate Expressing Ebolavir Ebola Virus Disease | Phase 1 | 2018-03-05 |
| Completed | Evaluating the Safety and Serum Concentrations of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523L HIV Infections | Phase 1 | 2018-02-28 |
| Completed | Challenge Infection of Healthy Adult Volunteers With RSV A2 Upper Respiratory Tract Infections | Phase 1 | 2018-02-20 |
| Completed | Co-Administration of AS03 Adjuvanted A/H7N9 IIV With IIV4 Avian Influenza, Influenza, Influenza Immunisation | Phase 2 | 2018-02-20 |
| Completed | Sanofi 2017 H7N9 With/Without AS03 in Adults/Elderly Avian Influenza, Influenza Immunisation | Phase 2 | 2018-02-14 |
| Completed | A Safety, Tolerability, Pharmacokinetics and Immunogenicity Trial of Co-administered MERS-CoV Antibodies REGN3 Corona Virus Infection | Phase 1 | 2018-02-12 |
| Completed | A Study to Evaluate the Safety, Tolerability and Plasma PK of a Single Oral Dose of Zoliflodacin in Healthy Ma Gonorrhoea | Phase 1 | 2018-02-02 |
| Completed | Evaluating the Pharmacokinetics, Safety, and Tolerability of Delamanid in Combination With Optimized Multidrug Tuberculosis, HIV Infections | Phase 1 / Phase 2 | 2018-01-30 |
| Completed | Community Dynamics of Malaria Transmission and Mosquito Feeding in Bancoumana, Mali Malaria | — | 2018-01-28 |
| Completed | Evaluating the Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Thera HIV Infections | Phase 3 | 2018-01-19 |
| Completed | Evaluating the Safety and Immunogenicity of ALVAC-HIV and MF59®- or AS01B-adjuvanted Bivalent Subtype C gp120 HIV Infections | Phase 1 / Phase 2 | 2018-01-16 |
| Active Not Recruiting | Safety and Tolerability of AAV8 Delivery of a Broadly Neutralizing Antibody in Adults Living With HIV: a Phase HIV-1 Infected Adults With Controlled Viremia | Phase 1 | 2018-01-11 |
| Completed | Evaluating the Safety and Immunogenicity of an HIV Vaccine (gp145 C.6980) in Healthy, HIV-Uninfected Adults in HIV Infections | Phase 1 | 2017-12-27 |
| Completed | JBT-101 in Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus, SLE, Lupus | Phase 2 | 2017-12-21 |
| Completed | Age and Response to Flu Vaccines Influenza, Influenza Immunisation | Phase 4 | 2017-12-14 |
| Terminated | Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) Lower Respiratory Tract Infection | N/A | 2017-12-08 |
| Completed | Ebola Virus Disease Survivors: Clinical and Immunologic Follow-up Ebola Virus Disease | — | 2017-12-02 |
| Completed | Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant Primary Immunodeficiency, PID | Phase 1 / Phase 2 | 2017-12-01 |
| Completed | Evaluation of the Efficacy of the Live Attenuated Tetravalent Dengue Vaccine Against DENV-2 and DENV-3 Challen Dengue | Phase 1 | 2017-11-28 |
| Active Not Recruiting | Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for P HIV Infections | Phase 3 | 2017-11-07 |
| Completed | A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children Asthma | Phase 2 | 2017-11-07 |
| Completed | PREDICT Cytomegalovirus (CMV) Lung Transplant | — | 2017-10-31 |
| Recruiting | An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease an Crohn's Disease | Phase 1 / Phase 2 | 2017-10-30 |
| Completed | Safety and Pharmacokinetic Study of Dapivirine Gel (0.05%) Administered Rectally to HIV-1 Seronegative Adults HIV Infections | Phase 1 | 2017-10-26 |
| Completed | Influenza HA Ferritin Vaccine, Alone or in Prime-Boost Regimens With an Influenza DNA Vaccine in Healthy Adult Influenza | Phase 1 | 2017-10-25 |
| Completed | Safety and Immunogenicity of pDNA Vaccines Expressing HIV M Group p24^Gag Conserved Elements and/or p55^Gag, A HIV Infections | Phase 1 | 2017-10-18 |
| Completed | Evaluating the Infectivity, Safety, and Immunogenicity of a Respiratory Syncytial Virus Vaccine (RSV 6120/∆NS2 RSV Infection | Phase 1 | 2017-10-13 |
| Terminated | Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Pemphigus Foliaceus, Pemphigus Vulgaris | Phase 1 | 2017-10-10 |
| Completed | Targeted Microbiome Transplant in Atopic Dermatitis Atopic Dermatitis (AD) | Phase 1 / Phase 2 | 2017-09-28 |
| Completed | Evaluating the Infectivity, Safety, and Immunogenicity of Recombinant Live-Attenuated RSV Vaccines RSV ΔNS2/Δ1 Respiratory Syncytial Virus Infections | Phase 1 | 2017-09-22 |
| Completed | Evaluating the Pharmacokinetics, Safety, and Tolerability of Bedaquiline in Infants, Children, and Adolescents Tuberculosis, HIV | Phase 1 / Phase 2 | 2017-09-21 |
| Completed | Brentuximab Vedotin for Systemic Sclerosis Diffuse Cutaneous Systemic Sclerosis, Scleroderma, dcSSc | Phase 1 / Phase 2 | 2017-09-20 |
| Completed | A Study in Healthy Adults to Assess Priming With Antigenically Mismatched Live Attenuated A/H7N3 Influenza Vir Influenza | Phase 1 | 2017-09-19 |
| Completed | Treatment of Gardnerella Vaginalis Vaginal Colonization With Amoxicillin Vaginitis Gardnerella | Phase 2 | 2017-09-11 |
| Completed | PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term S Ebola Virus Disease | — | 2017-09-04 |
| Completed | YCFM (Youth Correctional Facilities Males) Chlamydial Infection | Phase 2 | 2017-08-24 |
| Completed | Evaluating the Safety and Immunogenicity of EnvSeq-1 and CH505 M5 gp120 Envs Adjuvanted With GLA-SE in Healthy HIV Infections | Phase 1 | 2017-08-22 |
| Recruiting | Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-M Multiple Sclerosis | Phase 1 / Phase 2 | 2017-08-11 |
| Completed | Novel Mobile Device Application to Improve Adherence Pediatric Heart Transplant Recipients, Pediatric Cardiac Transplantation, Pediatric Heart Transplantation | N/A | 2017-08-10 |
| Recruiting | NIAID Centralized Sequencing Protocol Atopy, Primary Immunodeficiency, Autoimmunity | — | 2017-07-31 |
| Completed | Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3K Plasmodium Falciparum Infection | Phase 1 | 2017-07-26 |
| Completed | Impact of a Short-Term Analytical Treatment Interruption and Re-Initiation of Antiretroviral Therapy on Immuno HIV | — | 2017-07-17 |
| Completed | Using Biomarkers to Predict TB Treatment Duration Pulmonary Tuberculosis | Phase 2 | 2017-06-21 |
| Completed | Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine HIV Infections | Phase 1 / Phase 2 | 2017-06-19 |
| Completed | Atopic Dermatitis (AD) and Food Allergy Atopic Dermatitis (AD), Non-atopic Healthy Controls | — | 2017-06-12 |
| Completed | A Systems Biology Approach to Malaria Immunity Plasmodium Falciparum Infection | Phase 1 | 2017-06-07 |
| Completed | Dose Escalation PfSPZ-CVac Malaria | Phase 1 | 2017-06-05 |
| Completed | Evaluating the Safety and Pharmacokinetics of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 In HIV Infections | Phase 1 | 2017-06-05 |
| Completed | Phase I Trial of Measles Vectored Chikungungya Vaccine Chikungunya Virus Infection | Phase 1 | 2017-05-30 |
| Completed | Multiple Ascending Dose Study of Oxfendazole in Healthy Adult Volunteers Helminthic Infection | Phase 1 | 2017-05-12 |
| Completed | Phase 1, Open-label, Single Dose Study to Examine Safety, Tolerability, Pharmacokinetics and Virologic Impact HIV-1 | Phase 1 | 2017-04-24 |
| Completed | Experimental Human Infection With Neisseria Gonorrhoeae Gonococcal Infection | Phase 1 | 2017-04-23 |
| Completed | Beginning Assessment of Cutaneous Treatment Efficacy of Roseomonas in Atopic Dermatitis Atopic Dermatitis | Phase 1 / Phase 2 | 2017-04-20 |
| Active Not Recruiting | Screening for Alpha Thalassemia in Healthy Volunteers Alpha Thalassemia | — | 2017-04-17 |
| Completed | Evaluating the Infectivity, Safety, and Immunogenicity of a Single Dose of a Recombinant Live-Attenuated Respi Respiratory Syncytial Virus Infections | Phase 1 | 2017-04-06 |
| Completed | Safety and Efficacy of Sanaria's PfSPZ-CVac in Malian Adults Plasmodium Falciparum Infection | Phase 1 | 2017-04-06 |
| Completed | VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and Adolescents Zika Virus, Zika Virus Infection, Virus Diseases | Phase 2 | 2017-03-29 |
| Terminated | CD8 Reactivity to Microorganisms in Blood and Breast Milk Immune Modulation, Tuberculosis, Leprosy | — | 2017-03-28 |
| Completed | Partnership for Research on Ebola VACcinations Ebola Virus Disease | Phase 2 | 2017-03-27 |
| Completed | A Safety Trial to Test MVA-BN(R)-Filo and Ad26.ZEBOV Vaccines in Healthy Volunteers Ebola Disease, Marburg Disease | Phase 1 | 2017-03-24 |
| Completed | Microbial, Immune, and Metabolic Perturbations by Antibiotics (MIME Study) Normal Physiology, Healthy | Phase 1 | 2017-03-22 |
| Completed | Phase I, Randomized, Double-blinded, Placebo-Controlled Dose De-escalation Study to Evaluate Safety and Immuno Zika Virus Infection | Phase 1 | 2017-03-21 |
| Completed | Evaluating PK, Tolerability, and Safety of Rifapentine and Isoniazid in Pregnant and Postpartum Women Tuberculosis | Phase 1 / Phase 2 | 2017-03-13 |
| Completed | Evaluating the Safety, Pharmacokinetics, and Anti-Viral Activity of VRC01 and VRC01LS in the Serum and Mucosa HIV Infections | Phase 1 | 2017-03-01 |
| Completed | Dose, Safety, Tolerability and Immunogenicity of a Stabilized Prefusion RSV F Subunit Protein Vaccine, VRC-RSV Respiratory Syncytial Virus | Phase 1 | 2017-02-22 |
| Completed | Etiology of Eczema Herpeticum (EH) Eczema Herpeticum | — | 2017-02-22 |
| Completed | VRC 605: Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB075-00-AB (VRC07-523LS), Admini HIV Prevention | Phase 1 | 2017-02-21 |
| Completed | Impact of Malaria on Pregnant Women in Ouelessebougou, Mali Malaria | — | 2017-02-15 |
| Completed | Safety and Immunogenicity of a First-in-Human Mosquito Saliva Peptide Vaccine Mosquito-Borne Disease | Phase 1 | 2017-02-15 |