NCT07181096

Frailty Among Renal Transplant Recipients and Relation to Chronic Allograft Dysfunction

Study of Frailty Among Renal Transplant Recipients, Its Relation to Chronic Renal Allograft Dysfunction

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Alexandria University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to assess prevalence of frailty among renal transplant recipients in Alexandria University Hospitals and to study the relation between frailty and chronic allograft dysfunction.

Detailed description

With respect to correlates of frailty, although higher comorbidity burden is also a risk factor for frailty among KT candidates, frailty can also occur in the setting of lower comorbidity burdens. Diabetes and serum albumin concentration are also associated with frailty among prevalent dialysis patients. In addition, individuals with CKD and ESKD who are frail are also more likely to have cognitive impairment and sarcopenia, or low muscle mass, than their non-frail counterparts

Conditions

• Frailty
• Renal Transplant

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	assessment of frailty	This study is a prospective cross-sectional study to assess the prevalence of frailty among 80 cases of renal transplanted patients. Specific tests will include: 1. Assessment of frailty by Clinical Frailty Scale. 2. Assessment of nutritional status using Patient Generated Subjective Global Assessment (PG-SGA). 3. Comorbidity assessment using Charlson comorbidity score. 4. Six minutes walk test. 5. Muscle strength assessment using hand grip strength (HGS) dynamometer.

Timeline

• Start date: 2025-07-15
• Primary completion: 2025-12-15
• Completion: 2026-01-15
• First posted: 2025-09-18
• Last updated: 2025-09-18

Locations

1 site across 1 country: Egypt