Clinical Trials Directory

Trials / Sponsors / University Hospital Southampton NHS Foundation Trust

University Hospital Southampton NHS Foundation Trust

Academic / Other · 146 registered clinical trials28 currently recruiting.

StatusTrialPhaseStarted
Not Yet RecruitingIMMUNO-FIT Observational Study
Neoplasms, Immunotherapy, Physical Fitness
2026-02-01
RecruitingVirtual Group Prehabilitation Education (Surgery School) Feasibility Trial
Cancer Surgery, Elective Surgery, Patient Education
N/A2025-09-02
RecruitingA Qualitative Study Investigating the Lived Experiences and Impact of Reproductive Issues in Adults With Prima
Primary Ciliary Dyskinesia (PCD)
2025-09-02
Not Yet RecruitingValidation Of A Parent Administered Symptom Score For Unsettled Infants (Every Baby is UnIQue)
Colic, Infantile, Milk Allergy, Cow's, Gastro Oesophageal Reflux Disease
2025-09-01
RecruitingImproving Quality of Life for Teenagers With Asthma
Asthma in Children, Asthma
N/A2025-08-26
Not Yet RecruitingArtificial Intelligence to Detect Early Total Knee Replacement Implant Failure
Aseptic Loosening of Prosthetic Joint
2025-08-01
Not Yet RecruitingMitochondrial Assessment in Critical Ill Patients in Intensive Care
Critical Illness
2025-07-01
Not Yet RecruitingEthnography of Hospital Care for Adults With Learning Disabilities
Learning Disability, Adult
2025-06-01
CompletedThe Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burd
Older Adults (60 - 85 Years Old)
N/A2025-05-22
RecruitingSurveillance of Pancreatic Health After Diabetes Diagnosis
Diabetes Mellitus, Pancreatic Cancer, Adult
N/A2025-05-21
RecruitingThe PneumoRator Study
Respiratory, Monitored Anaesthesia Care, Perioperative
2025-04-25
Active Not RecruitingThe CardioFit Trial: Exercise Training Before Aortic Valve Surgery
Aortic Stenosis, Severe
N/A2025-01-28
RecruitingRisk Characterization of Non-culprit Vessels in Patients Undergoing Primary PCI for ST-elevation MI in Multive
ST Elevation Myocardial Infarction
2025-01-20
RecruitingTeicoplanin Allergy Testing Using Autologous Serum (TATAS)
Drug Allergy
N/A2025-01-08
CompletedNon-invasive Methods of Measuring Lung Volume
Respiration Disorders
N/A2024-11-20
Not Yet RecruitingHaemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid Haemorrhage
Subarachnoid Hemorrhage
N/A2024-11-01
Not Yet RecruitingEvaluating the Feasibility of High-volume, Low-risk Penicillin Allergy De-labelling to Maximise Efficiency in
Penicillin Allergy
N/A2024-10-01
Not Yet RecruitingPilot Study of Nitrate-rich Beetroot Juice Supplementation in Patients With Idiopathic Pulmonary Fibrosis (IPF
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
N/A2024-09-01
UnknownImplant of the WiSE CRT System With an Intracardiac Pacemaker
Heart Failure
2024-07-01
Not Yet RecruitingPreemie Milk Analyser Validation Study
Pre-Term, Breast Milk Expression, Nutrition Disorder, Infant
N/A2024-07-01
RecruitingUnderstanding the Variation of Modern Endoscopic Ultrasound Use in Patients with Oesophageal Cancer (VALUE)
Oesophageal Cancer
2024-06-27
RecruitingCardiac Arrest Bundle of cARE Trial
Cardiopulmonary Resuscitation, Cardiac Arrest, Out of Hospital Cardiac Arrest
N/A2024-05-24
CompletedThe RELISH Study: Compliance and Palatability of Oral Nutritional Supplements in Hospitalised Older Adults
Malnutrition
N/A2024-04-22
RecruitingLIving BEtteR With asThma - Intervention Development Study
Asthma
2024-04-19
RecruitingIRONHEART: Intravenous Iron in Non-ischaemic Heart Failure
Heart Failure, Iron Deficiencies
2024-04-15
RecruitingEarly Detection of At-risk Septic Patients
Sepsis
2024-01-12
RecruitingQualitative Study of Surgeons With Prospective Patient Follow-up
Necrotizing Enterocolitis
2024-01-01
UnknownRandomised Comparison of the Octaray and Pentaray Catheters
Atrial Fibrillation
N/A2023-09-01
Active Not RecruitingThe EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA)
Hypospadias, Anesthesia; Adverse Effect, Perioperative Complication
N/A2023-08-03
UnknownExploring the Experiences, Expectations and Preferences of Patients With the UHS COVID-19 Follow-up Clinic
COVID-19
2023-08-01
Not Yet RecruitingMitochondrial Function in the Peri-operative Setting: an Observational Study
Mitochondrial, Perioperative Complication, Surgery-Complications
2023-07-05
RecruitingRCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart
Heart Failure
N/A2023-04-12
UnknownPlatelet Reactivity in Non-cardiac Inflammation A Prospective Observational Single Centre Study.
Inflammatory Response, Platelet Aggregation, Spontaneous
2023-04-01
UnknownAtrial Fibrillation Driver Study
Atrial Fibrillation, Fibrosis Myocardial
2023-03-01
UnknownEye Movement Desensitisation and Reprocessing (EMDR) to Improve Mental Health Following Intensive Care Admissi
Post Traumatic Stress Disorder, Critical Illness, Eye Movement Desensitisation and Reprocessing
N/A2023-02-20
UnknownGut-Brain-Axis/Lung-Brain-Axis and Mental Ill Health in Critical Illness
Mental Health Issue, Critical Illness, Gut Microbiome
2023-02-14
UnknownPilot Trial of ExACT (Exercise as Airway Clearance Therapy) for People With Cystic Fibrosis
Cystic Fibrosis
N/A2023-02-02
CompletedFrail2Fit Study: Online Nutrition and Exercise Support for Older Adults With Frailty
Frailty, Malnutrition, Sedentary Behavior
N/A2022-10-28
RecruitingUtilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes
Progressive Supranuclear Palsy, Cortico Basal Degeneration, Multiple System Atrophy
2022-10-10
UnknownCortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
Mild Cognitive Impairment, Alzheimer Disease, Dementia
2022-09-28
UnknownVentricular Fibrillation Following Out-of-hospital Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation
2022-09-01
CompletedNiraparib Efficacy in Patient With Unresectable Mesothelioma
Mesothelioma, Malignant
Phase 22022-07-11
UnknownNeokare Safety and Tolerability Assessment in Neonates With GI Problems
NEC, Gastroschisis, Intestinal Perforation
2022-06-09
UnknownAtezolizumab Immunotherapy, in Immunotherapy Naive Patients With Urinary Tract Squamous Cell Carcinoma (UTSCC)
Squamous Cell Carcinoma, Urinary Tract Cancer
Phase 22022-05-30
Active Not RecruitingThe Influence of Mepolizumab on Structural and Inflammatory Cells in Severe Eosinophilic Asthma
Asthma; Eosinophilic
2022-05-25
Active Not RecruitingIntraoperative Electron Radiotherapy in Rectal Cancer - A Feasibility Trial
Locally Advanced Rectal Cancer, Locally Recurrent Rectal Cancer
N/A2022-05-18
RecruitingReconstruction in Extended MArgin Cancer Surgery
Surgery--Complications, Pelvic Cancer, Abdominal Cancer
2022-05-17
CompletedMAGNET Ingestion in Children
Foreign Bodies
2022-05-01
UnknownPsychological Support for Intensive Care Nurses During the COVID-19 Pandemic: The PROACTIVE Feasibility Trial
Psychological, Burnout, Post Traumatic Stress Disorder
N/A2022-01-13
RecruitingACTIVE-IBD Study: Physical Activity and Sleep in Paediatric Inflammatory Bowel Disease
Inflammatory Bowel Diseases, Exercise
2021-11-01
Active Not RecruitingAcalabrutinib in Combination With R-CHOP for Previously Untreated Diffuse Large B-cell Lymphoma (DLBCL)
Diffuse Large B Cell Lymphoma
Phase 22021-10-19
CompletedFeasibility of Visual Field Screening Apps
Visual Field Defect, Peripheral
2021-09-10
UnknownSevere Asthma, MepolizumaB and Affect: SAMBA Study
Severe Eosinophilic Asthma, Psychological Distress, Anxiety
2021-09-09
UnknownEvaluation of Volatile Organic Compounds in Mepolizumab Therapy
Asthma; Eosinophilic
2021-07-01
CompletedThe ENVI Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI
Heart Failure With Reduced Ejection Fraction
2021-06-09
UnknownSevere Asthma Covid Vaccine Response Study
Coronavirus Antibody Levels
2021-05-06
UnknownPrimary Prevention of Cytomegalovirus in Pregnancy: Addressing the Gaps (CMV GAP)
Cytomegalovirus Congenital
2021-05-03
UnknownTransthoracic Ultrasound Evaluation of Thoracic Aortic Aneurysms
Thoracic Aortic Aneurysm
2021-04-11
Not Yet RecruitingContinuously Iterative Perioperative Holistic Evaluation of Risk and Hypotension Prediction Index
Surgery--Complications
2021-04-01
CompletedImmune Responses to COVID-19 Vaccination in Lymphoma Patients
Classical Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Primary Mediastinal B Cell Lymphoma
2021-03-11
CompletedEarly EMDR Following Covid-19 Critical Illness: A Feasibility Trial
Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder, Anxiety Disorders
N/A2020-10-01
CompletedChildren's Eye Examination and Testing At Home Study
Amblyopia
N/A2020-07-06
UnknownIdentification of Novel Factors Leading to Activated Macrophage Expansion in COVID19 - INFLAME Study
Covid19, SARS-CoV-2 Infection
2020-06-30
CompletedA Clinical Trial of Nebulized Surfactant for the Treatment of Moderate to Severe COVID-19
Respiratory Infections
N/A2020-06-18
CompletedSafeFit Trial: Virtual Clinics to Deliver Universal Interventions in People With Cancer
Cancer, COVID
N/A2020-06-04
WithdrawnUse of Public Access Defibrillators by Untrained Bystanders
Cardiac Arrest, Sudden Death, Cardiac
N/A2020-04-01
UnknownCoronavirus Infection in Primary or Secondary Immunosuppressed Children and Adults.
Immune Suppression, Immune Deficiency, Infection
2020-03-22
UnknownDNA Repair in Patients With Stable Angina.
Coronary Artery Disease, Coronary Arteriosclerosis, DNA Damage
2020-02-05
UnknownUnruptured Intracranial Aneurysm Aspirin Trial (UIAAT).
Intracranial Aneurysm, Inflammation
Phase 22019-10-24
CompletedValidation of Respiratory Rate and Heart Rate Measurements by Capaciflectors Placed in Four Locations on the C
Exercise, Respiratory Rate, Heart Rate
2019-09-30
UnknownPErioperAtive CHildhood ObesitY
Pediatric Obesity, Obesity, Childhood, Overweight and Obesity
2019-09-09
CompletedHigh Density Scar Guided Atrial Fibrillation Mapping
Atrial Fibrillation
N/A2019-08-27
CompletedLate Potentials and Ablation Index in Ventricular Tachycardia Ablation
Ventricular Tachycardia
N/A2019-06-26
UnknownTransconjunctival vs Transcutaneous Anaesthesia in Oculoplastics
Anesthesia, Local, Eyelid Diseases
N/A2019-06-04
CompletedA Feasibility Study of Early Mobilisation Programmes in Critical Care
Critical Illness
N/A2019-05-28
UnknownDistribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality
Myocardial Infarction, Myocardial Injury
2019-01-28
CompletedPreoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
Unrecognized Condition
N/A2018-10-18
Active Not RecruitingPhase I Study of 131-I mIBG Followed by Nivolumab & Dinutuximab Beta Antibodies in Children With Relapsed/Refr
Neuroblastoma
Phase 12018-05-24
UnknownWomen's Responses to Adjusted Product Placement and Its Effects on Diet - 2
Diet Modification
N/A2018-05-09
TerminatedAtezolizumab, Rituximab, Gemcitabine and Oxaliplatin in Patients With Relapsed or Refractory DLBCL Not Suitabl
Diffuse Large B Cell Lymphoma, Relapsed Diffuse Large B-Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
Phase 22018-05-09
CompletedImproving Defibrillation Pad Position
Cardiac Arrest
2018-05-01
UnknownUsing Cardiovascular Magnetic Resonance Tissue Characterisation and Wearable Technology to PREDICT Clinical Ou
Heart Failure, Diffuse Fibrosis, Focal Fibrosis
2018-04-30
UnknownThe Wessex Fit-4-Cancer Surgery Trial
Cancer
N/A2018-03-26
Active Not RecruitingPerioperative UtiLisation of SupplEmental Oxygen
Anesthesia
Phase 42018-03-01
CompletedCArdio PulmOnary Exercise Testing and IntRAvenous Iron- 'CAPOEIRA-I STUDY'
Anemia, Anemia, Iron Deficiency
2018-02-02
CompletedDo Patients Suffering a Cardiac Arrest Present to the Ambulance Service With Symptoms in the Preceeding 48hrs?
Cardiac Arrest
2018-02-01
CompletedFractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management
Coronary Artery Disease
Phase 42017-12-04
CompletedA Combination of Rituximab and Varlilumab Immunotherapy in Patients with B-cell Lymphoma
B Cell Lymphoma
Phase 1 / Phase 22017-11-23
CompletedStructured Exercise Training Programme in Idiopathic Pulmonary Fibrosis
Breathlessness, Quality of Life, Idiopathic Pulmonary Fibrosis
N/A2017-09-22
WithdrawnFortified Foods in Older Inpatients
Malnutrition, Dementia, Aging
2017-09-01
CompletedIs the Current Threshold for Diagnosis of "Abnormality", Including Non ST Elevation Myocardial Infarction, Usi
Myocardial Infarction
2017-06-29
CompletedA Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL)
Non Hodgkin Lymphoma
Phase 1 / Phase 22017-06-02
UnknownUse of a Novel Radiopaque Embolic Agent in Prostatic Artery Embolisation for Symptomatic Benign Prostatic Enla
Benign Prostatic Hyperplasia
Phase 22017-06-02
UnknownRespiratory Syncytial Virus (RSV) and Vaccination in Pregnancy
Respiratory Syncytial Virus (RSV), Maternal Vaccine Exposure, Attitude
2017-06-01
CompletedUterine Fibroid Embolization (UFE) for Symptomatic Fibroids: Comparison of Gel-Bead to Commonly Used Embolic A
Uterine Fibroid, Embolization, Symptoms
N/A2017-04-24
CompletedIBD Self-management Website and Home Faecal Calprotectin Monitoring
Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
N/A2017-04-04
TerminatedA Study Assessing Colonisation & Immunogenicity After Nasal Inoculation With N. Lactamica and Eradication on D
Meningitis, Meningococcal
N/A2017-03-13
UnknownVEST: The UK Vedolizumab Real Life Experience Study in Inflammatory Bowel Disease
Ulcerative Colitis, Crohn's Disease
2017-02-03
UnknownSarcopenia and Physiology Assessments in Cancer Patients
Upper Gastrointestinal Disorders, Lower Gastrointestinal Disorders, Hepatobiliary Cancer
2017-01-01
CompletedReactive Oxygen Species Following Aortic Valve Replacement
Aortic Stenosis
2016-11-29
CompletedGenetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study
Urolithiasis
2016-10-12
CompletedEstimation of CPR Chest Compression Depth
Cardiac Arrest
N/A2016-10-01
UnknownOptiflow Preoxygenation
Preoxygenation, Apnoea, Anaesthesia
N/A2016-10-01
UnknownIn the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary An
Chest Pain, Stable Angina, Acute Coronary Syndrome
N/A2016-09-01
UnknownHORIZONS: Understanding the Impact of Cancer Diagnosis and Treatment on Everyday Life
Breast Cancer Female, Breast Neoplasm, Non-Hodgkin's B-cell Lymphoma
2016-08-01
CompletedWomen's Responses to Adjusted Product Placement and Its Effects on Diet - 1 (WRAPPED1)
Diet Modification
N/A2016-07-06
CompletedBoston Scientific COMET Wire Validation Study
Stable Angina
N/A2016-03-16
CompletedGrip Strength Routine Implementation (GRImP)
Frail Elderly, Inpatients
2015-07-01
Active Not RecruitingWessex Asthma Cohort of Difficult Asthma
Asthma
2015-04-22
CompletedLooking at the Physiological Response of Ergometry in Critical Care Patients
Critical Ill Patients
2015-03-17
WithdrawnSexual Function Questionnaire Total Hip Replacement
Arthritis
2014-10-01
UnknownPaediatric Post Pneumococcal Conjugate Vaccine Nasopharyngeal Carriage Study
S. Pneumoniae, Pneumococcal Conjugate Vaccine
2014-10-01
CompletedSafety of Nasal Influenza Immunisation in Egg Allergic Children - The SNIFFLE 2 Study
Egg Hypersensitivity
Phase 42014-09-01
CompletedThe Southampton Mealtime Assistance Roll-out Trial
Volunteer Mealtime Assistants
N/A2014-08-01
UnknownExercise Intervention During Chemotherapy in Advanced Lung Cancer Patients
Non Small Cell Lung Cancer, Non Small Cell Lung Cancer Stage IIIB, Non Small Cell Lung Cancer Metastatic
N/A2014-04-04
WithdrawnThe Effect of ScopeGuide on the Mental Workload of Endoscopist
Any Symptoms Requiring Colonoscopy
N/A2014-04-01
CompletedElectrical Safety of Implantable Cardioverter Defibrillators
Defibrillators, Implantable, Cardiac Arrest
2014-02-01
CompletedOpen Label Phase I/Randomised,Double Blind Phase II Study in mCRPC of AZD5363 In Combination With DP Chemother
Prostate Cancer
Phase 1 / Phase 22014-01-29
CompletedFeasibility Study of a Coping Intervention for Recurrent Miscarriage
Miscarriage
N/A2014-01-17
CompletedInvestigation of Synbiotic Treatment in NAFLD
Non-Alcoholic Fatty Liver Disease
N/A2013-12-01
CompletedSafety of Nasal Influenza Immunisation in Egg Allergic Children
Egg Hypersensitivity
2013-09-01
CompletedThe Effects of a 9 Week Exercise Programme on Fitness and Quality of Life in Rectal Cancer Patients After Chem
Rectal Cancer
N/A2013-08-01
CompletedMicrobiology & Immunology of the Chronically-inflamed Airway
Chronic Obstructive Pulmonary Disease (COPD)
2012-09-01
UnknownSingle Pulmonary Nodule Investigation
Malignant Neoplasm of Lung
2012-08-01
CompletedCPET and Outcome After Oesophagogastric Cancer Surgery
Upper Gastrointestinal Disorders
2012-06-01
CompletedGeko™ Plaster Cast Study, Deep Vein Thrombosis (DVT) Prophylaxis
Deep Vein Thrombosis
EARLY_Phase 12012-03-01
CompletedThe Addition of Ipilimumab to Carboplatin and Etoposide Chemotherapy for Extensive Stage Small Cell Lung Cance
Extensive Stage Small Cell Lung Cancer
Phase 22011-06-01
CompletedRATNO, Reducing Antibiotic Tolerance Using Nitric Oxide in CF - a Phase 2 Pilot Study
Cystic Fibrosis
Phase 22011-05-01
CompletedA Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib
Lymphoma, Large B-Cell, Diffuse
Phase 32011-04-01
CompletedClofarabine Pre-conditioning With Allogeneic Transplant for Acute Myeloid Leukaemia (AML)
Acute Myeloid Leukaemia, Myelodysplasia
Phase 1 / Phase 22011-02-01
CompletedWT1 Immunity Via DNA Fusion Gene Vaccination in Haematological Malignancies by Intramuscular Injection Followe
Leukaemia (Acute), Leukaemia (Chronic), Leukaemia (Acute Myeloid)
Phase 22011-02-01
CompletedSouthampton Mealtime Assistance Study
Malnutrition
N/A2009-11-01
CompletedTreatment of Non Alcoholic Fatty Liver Disease With n-3 Fatty Acids
Non-Alcoholic Fatty Liver Disease
Phase 42009-11-01
WithdrawnImodium Syrup Versus Imodium Tablets for Faecal Incontinence
Fecal Incontinence
Phase 42009-10-01
CompletedA Study to Assess Safety and Efficacy of a Novel Treatment, Keratinocyte Growth Factor (KGF), in Asthmatic Pat
Bronchial Asthma
Phase 22009-08-01
CompletedPrebiotics and Immune Function in Middle Aged Humans
Immune Function
Phase 1 / Phase 22009-04-01
CompletedDoes Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of C
Coronary Artery Disease
N/A2008-06-01
CompletedEvaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study
Sepsis
Phase 22008-04-01
UnknownCombination Chemotherapy and Rituximab in Treating Patients With Primary Mediastinal Diffuse Large B-Cell Lymp
Lymphoma
N/A2007-06-01
CompletedSalmon in Pregnancy Study
Dermatitis, Allergies, Asthma
N/A2007-05-01
CompletedCapecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer
Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer
Phase 32006-03-01
CompletedImplications for Treatment of the Metabolic Syndrome
Metabolic Syndrome
Phase 22006-02-01
UnknownFollow-Up Study of Patients Who Have Undergone Surgery for Stage I, Stage II, or Stage III Colorectal Cancer
Colorectal Cancer
2004-03-01
CompletedTargeted Radiotherapy in HSCT for Poor Risk Haematological Malignancy
Acute Leukaemia, Chronic Leukaemia, Myeloma
Phase 1 / Phase 22002-01-01
CompletedAn Investigation of Tumor Necrosis Factor (TNF)-Alpha in Asthma Using Biopsy Explants and Primary Bronchial Ep
Asthma
2000-07-01
CompletedPreconception Maternal Iodine Status and Offspring Cognitive Function:
Cognitive Function
1998-04-06