NCT07029243

Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis

Physical Prehabilitation With and Without Creatine/Whey Protein Supplementation Effects on Frailty In Patients With Cirrhosis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition/exercise prehabilitation app will maintain muscle health in patients with liver disease.

Conditions

• Cirrhosis
• Frailty
• Sarcopenia

Interventions

Type	Name	Description
BEHAVIORAL	HEAL-ME digital app	HEAL-ME is a digital prehabilitation app that provides semi-guided nutrition/exercise prehabilitation
DIETARY_SUPPLEMENT	Creatine supplementation	Patients will take 5g creatine supplementation daily for 13 weeks
DIETARY_SUPPLEMENT	Whey protein supplementation	Patients will take 35g whey protein supplementation daily
DIETARY_SUPPLEMENT	Placebo	Patients will be administered daily placebo supplementation.

Timeline

• Start date: 2026-04-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-06-19
• Last updated: 2026-03-06

Locations

1 site across 1 country: United States