Trials / Not Yet Recruiting
Not Yet RecruitingNCT06582992
DNA Methylation Trajectories in Aging
EPIGENETIC-SENSITIVE BIOMARKERS OF INFLAMMAGING FROM HEALTHY TO HEART FAILURE DISEASE
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 150 (estimated)
- Sponsor
- University of Campania Luigi Vanvitelli · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | RRBS | Measure of genomic regions with differentially methylated profiles and differentially expressed protein |
Timeline
- Start date
- 2024-11-01
- Primary completion
- 2025-06-01
- Completion
- 2025-11-01
- First posted
- 2024-09-03
- Last updated
- 2024-09-03
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT06582992. Inclusion in this directory is not an endorsement.