NCT06537232

Greens-Based Crossover Trial to Improve Epigenetic Aging in Adults

A Randomized Crossover-Controlled Trial Investigating the Epigenetic Impact of a Greens-Based Supplement in Adults

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Auburn University · Academic / Other
• Sex: All
• Age: 50 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The primary purpose of this study is to assess changes in epigenetic markers of aging and physiological parameters in overweight older adults consuming a mixed greens-based supplement over a 30-day period in a randomized crossover design.

Detailed description

Investigators will recruit 20 overweight/obese but otherwise healthy participants aged 50-65. Participants will be randomized to consume the greens-based supplement each morning for the first 30 days or second 30 days of the study. Usual diet, physical activity, and sleep patterns will be encouraged and monitored during the duration of the study. Phlebotomy will be conducted at baseline, 30-day crossover, and 60-day follow-up to assess DNA methylation in peripheral blood mononuclear cells. Visceral and total body fat, stool microbiome composition, and actigraphy will also be assessed.

Conditions

• Aging

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Greens-based Supplement	Participant will consume one serving of greens-based supplement per day in the morning, for 30 days.

Timeline

• Start date: 2024-09-04
• Primary completion: 2024-12-18
• Completion: 2025-03-01
• First posted: 2024-08-05
• Last updated: 2025-01-08

Locations

1 site across 1 country: United States