NCT06635369

Taurine in Periodontitis and Aging

The Role of Taurine in Periodontitis and Aging: a Preliminary Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (actual)
• Sponsor: Istanbul Medipol University Hospital · Academic / Other
• Sex: All
• Age: 26 Years
• Healthy volunteers: Accepted

Summary

Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.

Conditions

• Peridontal Disease
• Aging

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Periodontal Indices	Saliva, serum and periodontal indexes were obtained from patients

Timeline

• Start date: 2023-12-21
• Primary completion: 2024-05-01
• Completion: 2024-06-01
• First posted: 2024-10-10
• Last updated: 2024-10-10

Locations

1 site across 1 country: Turkey (Türkiye)