NCT06444594

Transient Receptor Potential Channels

Transient Receptor Potential Channels in Human Skin

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Penn State University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Conditions

• Aging

Interventions

Type	Name	Description
DRUG	TRPM8 Agonist	menthol gel 4-10%
DRUG	TRPV1 Agonist	camphor gel 5-20%
DRUG	TRPV4 Agonist	capsaicin gel 0.05-1%%
DRUG	TRPM8, TRPV4, TRPV1 Agonists	menthol (4-10%), capsaicin (0.05-1%), camphor (5-20%)
OTHER	Vehicle gel	Inactive vehicle gel

Timeline

• Start date: 2024-07-17
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2024-06-05
• Last updated: 2025-01-17

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study