NCT07093216

Healthy Aging Through Optimized Exercise

Understanding Response Variability to Optimize Exercise Efficacy for Improving Health Among Older Adults

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 304 (estimated)
• Sponsor: University of Alabama at Birmingham · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

here is enormous variation in how individuals respond to exercise and understanding the factors that drive this variation will guide individualized exercise prescriptions to improve or maintain health into older age. This study will help to elucidate reasons for the variation in the responses to exercise in older adults.

Detailed description

here is enormous variation in how individuals respond to exercise and understanding the factors that drive this variation will guide individualized exercise prescriptions to improve or maintain health into older age. Our multidisciplinary team will apply Multiphase Optimization Strategy Framework (MOST) principles to addresses the impacts of exercise intervention components (e.g. exercise timing, aerobic exercise intensity levels, resistance exercise intensity levels, and training volume levels), as well as participant-specific factors (e.g. age, sex, race, BMI, and medication use), on health domains of Intrinsic Capacity (locomotion, vitality, sensory, psychological, and cognition) among older adults in response to six months of supervised, center-based exercise training. This approach - unprecedented in the fields of exercise and aging - will provide comprehensive evidence to more fully understand the variation in the responses to exercise in older adults.

Conditions

• Aging

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	6 month exercise intervention

Timeline

• Start date: 2026-05-01
• Primary completion: 2031-04-30
• Completion: 2031-04-30
• First posted: 2025-07-30
• Last updated: 2025-07-30