NCT06956131

Metabolite Changes Following Consumption Of Different Protein Drinks In Singapore Older Adults

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: National University of Singapore · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The study aims to investigate the acute effects of different protein sources (i.e., casein, whey, soy) on metabolomic profiles (e.g., amino acids in the blood), along with other outcomes such as cognitive function, mood, and appetite. While the study does not directly aim to prevent, prognosticate, diagnose, or alleviate any disease, it may provide insights that could inform dietary recommendations and support disease prevention efforts in older adults.

Detailed description

This study will be a double-blind, randomised, placebo-controlled trial using a crossover study design. 25 older adults (aged 60 to 80) will be recruited and assigned to consume 4 different test drinks in a random order on 4 different visits. This study aims to investigate whether higher protein consumption of different sources will influence postprandial plasma and urinary metabolomic profiles, cognition, mood and appetite. The study will comprise 1 screening visit and 4 test visits separated separated by a minimum washout period of \>7 days

Conditions

• Aging
• Protein Metabolism

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Casein Protein Isolate Drink	30 g protein equivalent of casein protein isolate dissolved in \~250 mL of water
DIETARY_SUPPLEMENT	Whey Protein Isolate Drink	30 g protein equivalent of whey protein isolate dissolved in \~250 mL of water
DIETARY_SUPPLEMENT	Soy Protein Isolate Drink	30 g protein equivalent of soy protein isolate dissolved in \~250 mL of water
DIETARY_SUPPLEMENT	Maltodextrin Drink	30 g carbohydrate equivalent of maltodextrin powder dissolved in \~250 mL of water

Timeline

• Start date: 2025-05-20
• Primary completion: 2026-02-09
• Completion: 2026-12-01
• First posted: 2025-05-02
• Last updated: 2026-02-17

Locations

1 site across 1 country: Singapore