NCT06692543

Sedentary or Exercised : Neuromuscular and Immunometabolic Observations and Retrospection

Immunometabolic and Neuromuscular Markers of Vitality Capacity : SENIOR Protocol

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Accepted

Summary

The distinction between healthy and pathological ageing has given rise to the vitality capacity concept. Underlying the physiological aspect of ageing, vitality capacity is reflected in the neuromuscular function, metabolism, and immune and stress response. The three domains seem to deteriorate with age, except among individuals who have maintained physical activity throughout their lives. Furthermore, immune cells, particularly T lymphocytes, appear to play a key role in each dimension of vitality capacity, as well as in the mice ageing pathway. Investigators sought to determine the effect of lifelong physical activity on vitality capacity, and especially on T cell metabolism. In this optic, fourty healthy participants over the age of 55 will be allocated to two groups: 20 who have maintained physical activity for the past 30 years, and 20 who have not. Each participant's vitality capacity will be deeply tested and compared to their physical activity background.

Conditions

• Aging

Interventions

Type	Name	Description
OTHER	Active population	1 blood withdraw, questionnaire and tests
OTHER	Inactive population	1 blood withdraw, questionnaire and tests

Timeline

• Start date: 2025-04-14
• Primary completion: 2026-07-01
• Completion: 2026-12-01
• First posted: 2024-11-18
• Last updated: 2025-04-17

Locations

1 site across 1 country: France