NCT06349304

Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults

Impact of Regular Consumption of Grape on Eye Health and Regulation of Advanced Glycation End-products in Singapore Older Adults

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (estimated)
• Sponsor: National University of Singapore · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to understand the impacts of regular consumption of freeze-dried table grape powder on eye health and regulation of advanced glycation end products in Singapore older adults. The investigators hypothesize that regular consumption of freeze-dried table grape powder will promote improvements in eye health and lower levels of advanced glycation end products when compared to the placebo group.

Detailed description

The study will be a 16-week, double-blind, randomized, placebo-controlled trial using a parallel study design. 46 adults (aged 60 - 85) will be recruited and randomly assigned to the intervention or placebo group to investigate whether regular consumption of freeze-dried table grape powder (46g/d) can improve eye health parameters, blood/skin AGE and glycemic status, and reduce inflammation and oxidative stress. This study will consist of 1 screening visit and 5 study visits with 4-week intervals.

Conditions

• Macula; Degeneration
• Aging
• Advanced Glycation End Products

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Freeze-dried table grape powder	Consumption of grape powder as part of daily diet
DIETARY_SUPPLEMENT	Placebo grape powder	Consumption of placebo grape powder as part of daily diet

Timeline

• Start date: 2024-09-30
• Primary completion: 2025-08-01
• Completion: 2025-08-01
• First posted: 2024-04-05
• Last updated: 2024-11-14

Locations

1 site across 1 country: Singapore