NCT07449767

Effects of Short-Term Resistance Training on Diaphragm Thickness, Hepatic Fat Density, and Quality of Life in Healthy Older Men

Effects of Short-Term Resistance Training on Diaphragm Thickness, Hepatic Fat Density, and Quality of Life in Healthy Older Men: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Gümüşhane Universıty · Academic / Other
• Sex: Male
• Age: 60 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This randomized controlled trial investigated the effects of a four-week moderate-intensity resistance training program on diaphragm thickness, hepatic fat density, and health-related quality of life in healthy community-dwelling older men aged 60-75 years. Thirty participants were randomly assigned to a resistance training group or control group. Diaphragm thickness and hepatic attenuation were assessed using non-contrast computed tomography, and quality of life was evaluated using the SF-12 questionnaire. The primary outcome was change in diaphragm thickness. Secondary exploratory outcomes included hepatic fat density and SF-12 physical and mental health scores.

Detailed description

Aging is associated with progressive decline in respiratory muscle morphology, metabolic health, and perceived quality of life. While resistance training is well established for peripheral muscle adaptation, its short-term effects on diaphragm morphology and hepatic tissue density remain insufficiently investigated. This randomized controlled pre-test-post-test trial enrolled 30 healthy men aged 60-75 years. Participants were randomly allocated (1:1) to: Resistance Training Group (RT) Control Group (CON) The RT group completed a supervised moderate-intensity resistance training program three times per week for four weeks (30-40 minutes/session, RPE 12-15). The control group maintained usual daily activities. Primary Outcome: Change in diaphragm thickness (mm) assessed by non-contrast CT Secondary Outcomes (Exploratory): Hepatic attenuation (Hounsfield Units) via CT SF-12 Physical Health Score SF-12 Mental Health Score The study was approved by the Hitit University Scientific Research Ethics Committee (2025/0464) and conducted according to the Declaration of Helsinki.

Conditions

• Older Men
• Quality of Life
• Fatty Liver
• Resistance Training
• Aging

Interventions

Type	Name	Description
BEHAVIORAL	Resistance Training Group (RT)	Structured Moderate-Intensity Resistance Training
OTHER	Control	Participants maintained their usual daily routines without structured exercise intervention.

Timeline

• Start date: 2025-06-10
• Primary completion: 2025-07-25
• Completion: 2025-08-10
• First posted: 2026-03-04
• Last updated: 2026-03-05

Locations

1 site across 1 country: Turkey (Türkiye)