| Not Yet Recruiting | Stingless Bee Honey Mouth Rinse on Gingivitis NCT07461155 | Ministry of Higher Education, Malaysia | EARLY_Phase 1 |
| Not Yet Recruiting | CHEER Oral Health in Pregnancy Study NCT07377344 | University of California, San Francisco | N/A |
| Not Yet Recruiting | A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regio NCT07458464 | Colgate Palmolive | Phase 3 |
| Not Yet Recruiting | Frankincense and Herbal Extracts for Plaque-Induced Gingivitis: A Double-Blind RCT NCT07535229 | Oman Dental College | N/A |
| Not Yet Recruiting | Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival Bleeding NCT07499115 | Colgate Palmolive | Phase 3 |
| Not Yet Recruiting | Validity of a Self-reported Questionnaire for Periodontal Status in a Saudi Population NCT07397104 | Universiti Sains Malaysia | — |
| Not Yet Recruiting | Evaluation of the Safety and Efficacy of SALI-10 Probiotic Lozenges NCT07508839 | Ostia Sciences | N/A |
| Not Yet Recruiting | Effect of Individually Trained Oral Prophylaxis (iTOP) on Gingival Health in Orthodontic Patients NCT07468773 | Gulf Medical University | N/A |
| Not Yet Recruiting | Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial NCT07424846 | University of Washington | Phase 2 / Phase 3 |
| Not Yet Recruiting | Evaluation of the Effect of the Toothpaste on Delicate Gums NCT07494747 | Lacer S.A. | N/A |
| Not Yet Recruiting | Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodonta NCT07406867 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | — |
| Recruiting | Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and O NCT07501455 | Kenvue Brands LLC | N/A |
| Not Yet Recruiting | Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population NCT07410351 | Universiti Sains Malaysia | — |
| Not Yet Recruiting | Homemade Herbal Mouthwash in Gingivitis. A Randomized Clinical Trial. NCT07401069 | Cairo University | Phase 3 |
| Not Yet Recruiting | Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal I NCT07307716 | Riyadh Elm University | N/A |
| Recruiting | 6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established P NCT07414173 | Colgate Palmolive | Phase 4 |
| Recruiting | Effect of Morus Nigra Mouthwash on Gingivitis Treatment NCT07499596 | Inonu University | N/A |
| Not Yet Recruiting | A Person-centered, Theory-based, Intervention - Method Development Through the Integration of Digital Technolo NCT07306117 | Vastra Gotaland Region | N/A |
| Active Not Recruiting | Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Proble NCT07263698 | Colgate Palmolive | Phase 3 |
| Recruiting | The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils M NCT07364565 | King Abdullah University Hospital | N/A |
| Recruiting | Assessment of the Efficacy and Safety of OROXID® Oral Solution in Patients With Gingivitis NCT07270705 | ENIKAM d.o.o. | N/A |
| Recruiting | A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reduc NCT07255040 | HALEON | N/A |
| Not Yet Recruiting | Diagnostic Accuracy of Oral Images, OPGs, and Questionnaires vs. Clinical Assessment for Periodontal Disease NCT07164573 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | — |
| Active Not Recruiting | Motivational Interviewing to Improve Oral Hygiene in Adolescent Orthodontic Patients NCT07164989 | University of Alabama at Birmingham | N/A |
| Completed | A Study to Evaluate the Effect of a Test (Sodium Bicarbonate) Toothpaste on the Oral Microbiome NCT07273539 | HALEON | N/A |
| Recruiting | ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE NCT07530978 | Abant Izzet Baysal University | — |
| Completed | The Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis NCT07224828 | Colgate Palmolive | Phase 3 |
| Not Yet Recruiting | Comparison of the Efficacy of Oral Irrigator Versus Interdental Brushes in the Oral Hygiene of Patients With G NCT07005011 | Université de Reims Champagne-Ardenne | N/A |
| Completed | A Clinical Study Investigating the Efficacy of an Experimental Toothpaste Containing Stannous Fluoride in Impr NCT07169188 | HALEON | N/A |
| Recruiting | Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis NCT07256743 | Ostia Sciences | Phase 2 |
| Not Yet Recruiting | Digital Quantification of Dental Plaque Based on Intraoral Scanner Images NCT07152314 | University of Guarulhos | — |
| Completed | Comparison of 0.12% Chlorhexidine and MicroRepair ABX Mouthwash in Gingivitis Management NCT07088653 | University of Pavia | N/A |
| Active Not Recruiting | Assessing Gingivitis and Plaque From a Marketed Toothpaste NCT07158112 | Procter and Gamble | Phase 4 |
| Completed | Clinical Investigation of PerioGard (Test) Regimen NCT07210138 | Colgate Palmolive | Phase 3 |
| Recruiting | Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodon NCT07119840 | Khyber Medical University Peshawar | N/A |
| Recruiting | Lactoferrin-Based Oral Care for Periodontal Health in Pregnancy NCT07069140 | University of Pavia | N/A |
| Completed | Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis NCT07029438 | Colgate Palmolive | Phase 4 |
| Recruiting | Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy NCT07029360 | University of Pavia | N/A |
| Not Yet Recruiting | Micro-Needling Technique Using Ozonated Olive Oil in Periodontal Diseases NCT06990282 | Fayoum University | Phase 2 |
| Enrolling By Invitation | Parental Perception of Oral Health-Related Quality of Life in Sudanese Refugee vs. Egyptian Children NCT07011381 | Kafrelsheikh University | — |
| Active Not Recruiting | Evaluating Gingivitis and Systemic Biomarkers NCT06962956 | Procter and Gamble | Phase 1 |
| Completed | Clinical Investigation of Bleeding Reduction Efficacy on Toothpaste Containing 1.05% Chitosan NCT06955871 | Colgate Palmolive | N/A |
| Completed | A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health NCT06933368 | HALEON | N/A |
| Completed | The Effect of Probiotics on Gums Health and Bad Breath NCT06910397 | Al-Mustansiriyah University | N/A |
| Completed | Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control. NCT06892834 | Procter and Gamble | Phase 2 |
| Completed | Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Pla NCT06732466 | Colgate Palmolive | Phase 3 |
| Completed | Comparisons of Efficacy of Triphala and Chlorhexidine Mouthwash Against Plaque Accumulation and Gingivitis. NCT07426393 | Bangladesh Medical University | N/A |
| Not Yet Recruiting | Comparison of Canine Retraction Using Ni-ti Closed-coil Springs Vs Elastomeric Power Chains During Orthodontic NCT06567730 | Munnal Gulzar | N/A |
| Recruiting | Efficacy of an Amine and Zinc Lactate - Containing Mouthrinse in the Home-based Treatment of Plaque-induced Gi NCT06671106 | Università degli Studi di Ferrara | N/A |
| Completed | Full-mouth Electronic Toothbrush vs. Conventional Electronic Toothbrush NCT06561204 | University of Minnesota | N/A |
| Completed | A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash i NCT06660069 | HALEON | N/A |
| Completed | Efficacy of Matcha Tea on Patients With Biofilm-induced Gingivitis NCT06912958 | Ahmed Talib | N/A |
| Completed | Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss NCT06515483 | Indiana University | N/A |
| Not Yet Recruiting | EFFECTIVENESS OF ORAL HYGIENE INSTRUCTIONS GIVEN BY AI-GENERATED VIDEOS VS. TRADITIONAL APPROACH IN PERIODONTA NCT06622863 | Mohammed Bin Rashid University of Medicine and Health Sciences | N/A |
| Not Yet Recruiting | An Investigation of the Efficacy of OHEM for Improving Oral Hygiene in Children NCT06356402 | Ziauddin University | N/A |
| Completed | Clinical Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC) NCT06607172 | Colgate Palmolive | Phase 3 |
| Completed | A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improv NCT06602466 | HALEON | N/A |
| Completed | Clinical Research Study to Assess the Efficacy of Two Brushing Regimens NCT06240481 | Colgate Palmolive | Phase 3 |
| Recruiting | Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions NCT06961409 | Izmir Katip Celebi University | — |
| Completed | Evaluation of Salivary Biomarker Levels in Individuals With Different Periodontal Conditions NCT06558136 | Izmir Katip Celebi University | — |
| Completed | Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis NCT06565897 | Colgate Palmolive | Phase 2 |
| Not Yet Recruiting | Periodontal Disease and Salivary Mitofusin Levels NCT06510608 | Erzincan University | — |
| Completed | Guided Biofilm Therapy Compared to Traditional Cleaning for Treating Gingival Inflammation in Orthodontic Pati NCT07355517 | King Abdullah University Hospital | N/A |
| Recruiting | Oral Health Education and Message Framing Effect on Oral Health Status of Refugees in Egypt NCT06649760 | Alexandria University | N/A |
| Completed | Salivary and Serum Inflammatory Biomarkers in Diabetic Nephropathy by Periodontal Status NCT07498894 | Pamukkale University | — |
| Not Yet Recruiting | Association of Acne Vulgaris With Oral Hygiene and Gingivitis NCT06237387 | Erzincan University | — |
| Unknown | Periodontal Management in Hypertensive Patients (PERIOTENSION Trial I) NCT04328389 | University of L'Aquila | N/A |
| Completed | Derma Pen as Treatment of Gingivitis Induced by Orthodontics NCT06567405 | Safa Basiouny Alawy | N/A |
| Completed | Impact of Ultra-Processed Food Intake on Gingival Tissue Health NCT06411535 | University of Siena | N/A |
| Completed | Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients NCT06411522 | University of Siena | N/A |
| Completed | The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protec NCT06427499 | Colgate Palmolive | Phase 3 |
| Recruiting | Impact of Periodontal Supportive Therapy in Patients With Gingivitis and Periodontitis NCT06382753 | University of Catania | — |
| Completed | Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlli NCT06430060 | Colgate Palmolive | Phase 3 |
| Completed | Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health NCT06029283 | University of Maryland, Baltimore | N/A |
| Recruiting | Effectiveness of Two Health Education Interventions in the Prevention of Caries and Gingivitis in Orthodontic NCT05979805 | Universidad Nacional de Colombia | N/A |
| Recruiting | Application of Ultra-high Frequency Ultrasonography (UHFUS) to the Study of Gingival Tissues NCT06480825 | University of Pisa | — |
| Recruiting | Effectiveness of Dual Light Electric Toothbrush vs. Manual Toothbrush in Orthodontic Patients Undergoing Oral NCT06122805 | Children's Hospital Los Angeles | N/A |
| Completed | Anti-gingivitis Mouthrinse NCT06048627 | Colgate Palmolive | Phase 3 |
| Recruiting | Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Impr NCT06890676 | Missouri Department of Health and Senior Services | N/A |
| Completed | Dietary Diversities: Exploring the Influence of Keto Diet and Intermittent Fasting on Oral Health and Salivary NCT06597708 | Al-Mustansiriyah University | EARLY_Phase 1 |
| Recruiting | The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With NCT06507280 | Aydin Adnan Menderes University | N/A |
| Completed | Associations Between Birth Order, Sibship Size and Periodontal Disease NCT06240247 | Zeynep Tastan Eroglu | — |
| Completed | Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental NCT06244303 | Colgate Palmolive | Phase 3 |
| Completed | Circadian Clock Gene Expression in Periodontal Disease NCT07452783 | Inonu University | — |
| Unknown | The Effects of Green Tea and Salvadora Persica L. in Patients With Gingivitis NCT06211309 | University of Baghdad | Phase 2 |
| Completed | Effect of Non-Surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Biomarker Levels NCT06175624 | Biruni University | N/A |
| Completed | Effects Of Low Level Laser Therapy On Tooth Movement,Treatment Related Complications Of Gingivitis,Periodontit NCT04230096 | Aga Khan University | N/A |
| Completed | A Clinical Study Investigating the Effects of a Dentifrice Containing 0.454% Stannous Fluoride on Gingivitis T NCT06143670 | HALEON | N/A |
| Unknown | Evaluation of the Effectiveness of Different Toothbrushes in Children NCT06164496 | Marmara University | N/A |
| Completed | Regulatory T Cell With Related Interleukins in Periodontal Disease Progression NCT06135116 | Al-Azhar University | — |
| Enrolling By Invitation | The Impact of Non-surgical Periodontal Therapy on Patients' Halitosis, Taste Perception, and Smell Sensation NCT06063460 | Necmettin Erbakan University | — |
| Completed | Herbal Pralines - Oral Health NCT06090851 | Wuerzburg University Hospital | N/A |
| Completed | At-home Bleaching Using Clear Retainers NCT05835453 | Universidad Rey Juan Carlos | N/A |
| Completed | A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices NCT06140784 | Procter and Gamble | N/A |
| Completed | Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker NCT06016023 | Postgraduate Institute of Dental Sciences Rohtak | — |
| Unknown | Toothpaste With Sodium Carbonate in Patients With Gingivitis NCT06224699 | University of Catania | N/A |
| Active Not Recruiting | Efficacy of Devices in Maintaining Oral Health and Managing Periodontal and Interproximal Tissues: a RCT NCT07520994 | University of Roma La Sapienza | N/A |
| Completed | Impact of 2D:4D Ratio on Oral Hygiene and Gingival Health NCT07147998 | Okan University | — |
| Completed | Evaluating the Effectiveness of a Cognitive Behavioral Intervention (CBI) NCT05782348 | Howard University | N/A |
| Completed | Effectiveness of Different Types of Toothbrushes on Periodontal Health in Orthodontic Patients NCT06510179 | Okan University | N/A |
| Completed | Galectin Role in Periodontal Disease NCT06038812 | Fayoum University | N/A |
| Completed | The Effect of Enzyme-containing Mouth Spray on Oral Health Status and S.Mutans Levels in Paediatric Patients NCT05576610 | Hospital Universiti Sains Malaysia | N/A |
| Unknown | Cystic Fibrosis and Periodontal Diseases NCT06133335 | CHU de Reims | N/A |
| Unknown | The Effect of Pomegranate Peel, German Chamomile or Their Combination on Gingivitis NCT05951647 | Alexandria University | Phase 3 |
| Recruiting | Variation in Gingival Inflammatory Responses NCT05968742 | University of Washington | N/A |
| Recruiting | NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery NCT05813236 | Aesculap AG | N/A |
| Completed | Plaque Reduction Sesame-based Oil NCT06841380 | Christine Zürcher | N/A |
| Enrolling By Invitation | Evaluation of the Effects of Probiotic Toothpastes on Periodontal Health NCT06514664 | Kutahya Health Sciences University | N/A |
| Completed | Salivary Drug Concentration Exploratory Study of Cetylpyridinium Chloride Buccal Tablets NCT05802628 | Peking University People's Hospital | Phase 4 |
| Completed | Effects of 0.2% Hyaluronic Acid Gel-Impregnated Dental Flosses on Clinical Gingival Parameters NCT06307041 | Özlem SARAÇ ATAGÜN | N/A |
| Completed | Comparisons Of Different Antiplaque Agents On Gingivitis In Orthodontic Patients NCT06305546 | Anam Sattar | N/A |
| Unknown | Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for NCT05816512 | Ahmed Yousif Mahdi | N/A |
| Completed | Effectiveness of Brush DJ App in Improving Oral Hygiene Compliance of Fixed Orthodontic Patients NCT05853276 | IMU University, Malaysia | N/A |
| Completed | A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice D NCT05654662 | HALEON | N/A |
| Completed | Effectiveness of Toothbrushing Habits of Preschool Children, With or Without a Toothbrushing Assisting Applica NCT05788692 | National and Kapodistrian University of Athens | N/A |
| Unknown | Individual Variability of Experimental Gingivitis Response NCT05656417 | King's College London | — |
| Completed | Effects of Probiotic Ayran on Gingivitis NCT06437925 | Cukurova University | N/A |
| Completed | Protocol Efficacy of Mouthwashes in Experimental Gingivitis NCT07270952 | Stony Brook University | Phase 4 |
| Completed | The Efficacy of Different Adjunctive Plaque Control Modalities in Orthodontic Patients NCT05889975 | University of Baghdad | Phase 3 |
| Completed | Plaque Inhibitory Effect of Neutral Electrolysed Water in the Form of a Mouthwash in a 4-day Non-brushing Mode NCT05709015 | University of Ljubljana | Phase 2 |
| Completed | Effect of Nigella Sativa Toothpaste on Salivary Biomarkers in Patients With Gingivitis NCT07447349 | Universitas Airlangga | N/A |
| Completed | Artificial Intelligence Evaluation of Periodontal Health Using Selfie Intraoral Photography NCT04326413 | The University of Hong Kong | — |
| Completed | Evaluation of Mandibular Bone Microstructure Changes After Periodontal Treatment (M-BONE Study) NCT07488403 | Akdeniz University | — |
| Unknown | EFFECT OF SCALING ON SERUM hsCRP LEVELS AND PERIODONTAL PARAMETERS IN SYSTEMICALLY HEALTHY YOUNG WOMEN WITH GI NCT05639608 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Efficacy of an Antibacterial Toothpaste and Patients' Satisfaction NCT05569850 | University of Bologna | N/A |
| Completed | GumChucks vs Interdental Brushes in Plaque Removal. NCT07140068 | Beirut Arab University | N/A |
| Completed | Toothpastes With Thermal Water for Oral Health NCT05623761 | I.M. Sechenov First Moscow State Medical University | Phase 4 |
| Unknown | Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents NCT06291129 | Universidade Federal Fluminense | N/A |
| Completed | Intraoral Scanners as a Motivation Method for Oral Hygiene Instruction NCT05079204 | CHU de Reims | N/A |
| Unknown | Interleukin-38 Levels in Individuals With Periodontitis NCT05568290 | Saglik Bilimleri Universitesi | — |
| Unknown | The Assessment of Clinical Efficacy of Topical Application of 5% Thymoquinone Gel for Gingivitis Patients NCT05497895 | King Abdulaziz University | EARLY_Phase 1 |
| Recruiting | Imaging-based Assessment of Oral Biofilm and Gingival Health NCT05470023 | University of California, Irvine | N/A |
| Completed | Peri-implant Conditions Mimic Periodontal Conditions NCT06128850 | Abant Izzet Baysal University | — |
| Completed | Plaque Reduction Sesame Oil NCT06327841 | Medical University Innsbruck | N/A |
| Unknown | ONE-1 Oral graNd Est 1 NCT05089214 | Central Hospital, Nancy, France | N/A |
| Completed | Metagenome Resilience in Experimental Gingivitis NCT05389124 | Newcastle University | — |
| Completed | Clinical Evaluation and Assesment of Ginigivitis Patients Treated by Yarrow Natural Extract in Compare to a Co NCT06070571 | Deraya University | Phase 1 |
| Completed | Fractalkine-CX3CR1 Axis in Periodontal Therapy NCT07307144 | Giresun University | N/A |
| Recruiting | Intraoral Scanners as Periodontal and Dental Pathologies Diagnosis Tools NCT06006429 | CHU de Reims | N/A |
| Completed | Stannous Fluoride and Gingivitis NCT05326373 | Procter and Gamble | N/A |
| Completed | Propolis Containing Chewing Gum and Gingivitis NCT06685419 | naksaka | — |
| Completed | A Meta-analysis Comparing Toothbrushes on Plaque Removal and Gingival Health NCT05594004 | Procter and Gamble | — |
| Recruiting | Effect of Probiotics on the Periodontal Status of Orthodontic Patients NCT04634201 | University Hospital, Lille | N/A |
| Completed | Evaluation of the Effect of Non-Surgical Periodontal Treatment in Women With Polycystic Ovary Syndrome NCT06567132 | Bezmialem Vakif University | N/A |
| Unknown | Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases NCT06075680 | Marmara University | N/A |
| Completed | Air Polishing Effect on Biological, Clinical and Patient-reported Experience Among Epileptic and Non-epileptic NCT06144034 | King Abdullah University Hospital | N/A |
| Completed | Anti-Inflammatory Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis NCT05868200 | University of Baghdad | Phase 3 |
| Completed | Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste. NCT06563518 | Colgate Palmolive | Phase 2 |
| Completed | Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation NCT05268757 | University of Copenhagen | N/A |
| Completed | Asprosin Level in Individuals With Periodontal Disease NCT06627972 | Mustafa Kemal University | — |
| Recruiting | AI Gum Health Evaluation with Smartphone NCT05685355 | The University of Hong Kong | — |
| Completed | Effect of EE/NETA With Scaling on Periodontium and hsCRP in PCOS Women With Gingivitis NCT05129878 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | The Effect of A Dental Application to Promote Self-Administered Plaque Control: A RCT NCT05073107 | National University Hospital, Singapore | N/A |
| Completed | A Three Month Bleeding-Model Clinical Study NCT05916521 | Procter and Gamble | N/A |
| Completed | A Study of Experimental Mouthwashes NCT05121909 | Johnson & Johnson Consumer Inc. (J&JCI) | Phase 4 |
| Completed | Effect of Probiotics on Oral Homeostasis During Sugar Stress NCT05073393 | University of Copenhagen | N/A |
| Active Not Recruiting | Dental Biofilm Control During Orthodontic Treatment NCT05532241 | University of Rijeka | Phase 3 |
| Unknown | Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen NCT05021861 | Postgraduate Institute of Dental Sciences Rohtak | — |
| Completed | A Clinical Study to Assess the Gingivitis Effects of Various Dentifrices NCT06140771 | Procter and Gamble | N/A |
| Completed | Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Syst NCT04649645 | Eclat Srl. | N/A |
| Completed | Clinical Study to Investigate a New Mouthwash in Reducing Plaque and Helping Prevent Gum Problems on Dental Im NCT06770114 | Colgate Palmolive | Phase 3 |
| Completed | The Effect of Virtual Reality Glasses on Dental Anxiety Control NCT05038540 | Kutahya Health Sciences University | N/A |
| Not Yet Recruiting | COMORAL® the Oral Irrigation Unit Clinical Trial NCT05031260 | University of California, Los Angeles | N/A |
| Completed | Antiplaque Efficacy of Two Novel Commercially Available Herbal Toothpastes. NCT05363956 | Ajman University | Phase 1 |
| Completed | Effectiveness in Dental Plaque Reduction of Mouthwashes Containing Fatty Acids Compounds (F.A.G.) or Stannous NCT04977778 | University of L'Aquila | N/A |
| Completed | Evaluation of 3 Oral Self-care Regimens on Clinical Signs of Inflammation and Plaque NCT05766995 | Water Pik, Inc. | N/A |
| Unknown | Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Le NCT04946617 | Istanbul Medeniyet University | — |
| Completed | Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP NCT05258721 | Rowpar Pharmaceuticals, Inc. | Phase 2 |
| Completed | Evaluation of Toothbrush Bristles in Plaque Reduction NCT04681885 | Sunstar Americas | N/A |
| Completed | Measuring Efficacy of an Oral-Irrigator After Three Weeks of Use NCT04899440 | Procter and Gamble | — |
| Unknown | (NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis NCT04850768 | Saglik Bilimleri Universitesi | — |
| Completed | A Twelve Week Study of Experimental Mouth Rinses NCT05120141 | Johnson & Johnson Consumer Inc. (J&JCI) | Phase 4 |
| Completed | A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium NCT04737538 | GlaxoSmithKline | Phase 2 |
| Completed | Gingivitis and Periodontitis as a Risk Factor for Stroke NCT05101434 | Shaheed Zulfiqar Ali Bhutto Medical University | — |
| Completed | Effect of an Enzyme-containing Lozenge on Dental Biofilm in Healthy Individuals. NCT05070507 | Novozymes A/S | N/A |
| Completed | Oral Health Care in Stroke Patients in Tertiary Care Hospital NCT05114681 | Shaheed Zulfiqar Ali Bhutto Medical University | — |
| Unknown | Effectiveness of Salvadora Persica Miswak in Improving Plaque Control and Gingival Health NCT04650685 | National University of Malaysia | N/A |
| Completed | The Clinical Assessment of Nigella Sativa Oil vs Chlorohexidine as a Therapeutic Aid for Gingivitis, Effect on NCT05069246 | Ishrat Rahman | Phase 2 |
| Unknown | Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodonti NCT04598633 | University of Erlangen-Nürnberg | N/A |
| Completed | Photodynamic Therapy in Patients With Gingivitis NCT04037709 | University of Nove de Julho | N/A |
| Unknown | Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodonti NCT04606186 | University of Erlangen-Nürnberg | N/A |
| Completed | A Bleeding-Model Clinical Study NCT05916508 | Procter and Gamble | N/A |
| Completed | To Compare the Effectiveness of Three Self-care Oral Hygiene Regimens NCT04804670 | Water Pik, Inc. | N/A |
| Completed | A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Pa NCT04290624 | HALEON | Phase 4 |
| Completed | Clinical Effectiveness of 5 Different Mouthwashes in the Treatment of Generalised Gingivitis NCT04733196 | Plovdiv Medical University | N/A |
| Completed | Meteorin-like Levels in Individuals With Periodontitis NCT04402996 | Istanbul Saglik Bilimleri University | — |
| Completed | Gingivitis Reduction After Use of 0.45% Stannous Fluoride Toothpaste NCT06300866 | Colgate Palmolive | Phase 3 |
| Completed | ToothWave Calculus Reduction and Accumulation Prevention Study NCT04596761 | Home Skinovations Ltd. | N/A |
| Unknown | Efficacy of Hyaluronic-acid and Hydrogen-Peroxide Mouthwash in Gingivitis Treatment NCT04438421 | University of Milan | Phase 3 |
| Unknown | Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic NCT05217277 | Marmara University | — |
| Completed | Effect of a 2-week Sugar Stress on Bacterial Profiles in Whole Saliva NCT04199897 | University of Copenhagen | N/A |
| Unknown | Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health NCT04197427 | You First Services | N/A |
| Completed | Asprosin, Adropin, Irisin Levels in Periodontitis NCT06250764 | AYSAN LEKTEMUR ALPAN | — |
| Completed | To Evaluate the Efficacy of Probiotics Toothpastes in Improvement of Gingivitis and Prevention of Periodontal NCT04190485 | GenMont Biotech Incorporation | N/A |
| Completed | Miswak Efficacy Compared With Chlorhexidine NCT04607785 | Al-Iraqia University | EARLY_Phase 1 |
| Completed | Comparison of the Effects of Oil Pulling Therapy With Different Oils NCT04737798 | Baskent University | N/A |
| Unknown | The Association of Blood Haemoglobin and Colour of Gums NCT03791957 | KLE Society's Institute of Dental Sciences | — |
| Completed | Determination of the Levels of Lipocalin-2 and Semaphorin3A NCT04390997 | Izmir Katip Celebi University | N/A |
| Completed | Plaque Removal Effectiveness of a Flossing Device Compared to the Conventional Flossing in Adults NCT06318819 | Maha A. Bahammam | N/A |
| Completed | Atlas of Experimental Gingivitis in Humans NCT04105569 | University of North Carolina, Chapel Hill | N/A |
| Completed | Six Week Study of Experimental Mouth Rinses: Effect on Gingivitis and Plaque NCT04921371 | Johnson & Johnson Consumer Inc. (J&JCI) | Phase 1 |
| Completed | A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health Aft NCT04050722 | GlaxoSmithKline | Phase 4 |
| Completed | Impact of Oral Probiotics on Oral Homeostasis NCT04071210 | University of Copenhagen | N/A |
| Completed | Diagnostic Accuracy of Rapid Non-clinical Screening Tests for Early Detection of Periodontitis NCT03928080 | The European Research Group on Periodontology (ERGOPerio) | — |
| Completed | Safety and Efficacy of the ToothWave -12 Weeks Calculus Study NCT04092075 | Home Skinovations Ltd. | N/A |
| Completed | A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis NCT03694444 | Amyndas Pharmaceuticals S.A. | Phase 1 / Phase 2 |
| Completed | Self-selection Study of the Toothwave Toothbrush NCT04023097 | Home Skinovations Ltd. | N/A |
| Completed | Efficacy of the Addition of a Power Interdental Device to an Electric Toothbrush on Gingival Health. NCT04003298 | Water Pik, Inc. | N/A |
| Completed | Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected Toothbru NCT04221334 | Colgate Palmolive | N/A |
| Completed | Pooled Analysis of Clinical Data From Six GSK Studies to Investigate the Efficacy of a Dentifrice Containing 6 NCT03703245 | GlaxoSmithKline | — |
| Completed | Effect of Miswak Chewing Sticks on Periodontal Pathogens and Its Impact on the Progression of Gingivitis NCT04123002 | King Saud Bin Abdulaziz University for Health Sciences | N/A |
| Completed | Oral Hygiene and Systemic Inflammation (Perio-Hygiene 1.0) NCT03848351 | University of Pisa | N/A |
| Completed | Activin-A and Interleukin-1β Levels in Periodontitis NCT06110221 | Aydin Adnan Menderes University | — |
| Completed | GCF Bax and Bcl-xl Levels in Periodontitis NCT06443372 | Aydin Adnan Menderes University | — |
| Completed | Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste NCT04033575 | Colgate Palmolive | Phase 4 |
| Completed | miRNAs in Periodontal Disease NCT05046678 | Bulent Ecevit University | — |
| Completed | ToothWave Plaque and Gingivitis Study NCT03885323 | Home Skinovations Ltd. | N/A |
| Completed | Effectiveness of Propolis Mouthwash on Gingivitis NCT04032548 | Mahsa University | N/A |
| Completed | Efficacy of Oil Pulling Therapy on Supragingival Plaque Growth NCT03962777 | Baskent University | N/A |
| Completed | Evaluation of Air Polishing With Ultrasonic Debridement in the Treatment of Initial Periodontal Pockets NCT03863093 | Syrian Private University | N/A |
| Completed | Effect of Oral Health Education on Oral Health Status, Treatment Needs and Barriers to Care NCT04317768 | Jordan University of Science and Technology | N/A |
| Completed | Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Pat NCT03841825 | Virginia Commonwealth University | N/A |
| Completed | Silver Diamine Fluoride and Gingivitis in Geriatric Patients NCT03445286 | Texas A & M University Baylor College Of Dentistry | N/A |
| Completed | OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study. NCT03839719 | Government College of Dentistry, Indore | N/A |
| Completed | Clinical Study to Assess Therapeutic Delay and Resolution of Induced Gingivitis NCT05731778 | Colgate Palmolive | Phase 4 |
| Completed | Inflammatory Biomarkers in Saliva at Depression NCT06427902 | Medipol University | — |
| Completed | Influence of the Restorative Cervical Margin Placement on the Supracrestal Tissue Attachment NCT04299347 | University of Siena | — |
| Unknown | Interdental Microbiota Among Adolescents NCT03700840 | Université Montpellier | N/A |
| Completed | A Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice NCT03936569 | Procter and Gamble | Phase 4 |
| Unknown | Diet, Diabetes and Periodontitis NCT03407508 | Kristianstad University | Phase 1 / Phase 2 |
| Completed | Correlation Between Oral Health and Systemic Inflammation (COHESION) NCT03641989 | Marshfield Clinic Research Foundation | N/A |
| Completed | Dietary Collagen Peptides and Periodontal Inflammation NCT03765125 | Wuerzburg University Hospital | N/A |
| Completed | A Clinical Comparison of an Experimental Power Brush Compared to a Manual Toothbrush NCT03624647 | Procter and Gamble | N/A |
| Completed | Effectiveness of the Use of Dental Floss NCT04909840 | Universidade Federal de Santa Maria | N/A |
| Completed | Results From Objective Brushing Data Saved From a Powered Toothbrush Related to Values for Oral Health NCT05941611 | Blekinge Institute of Technology | N/A |
| Completed | eDENT Oral Health- the Gateway to Quality of Care and Everyday Life at Old Age NCT06011564 | Blekinge Institute of Technology | N/A |
| Completed | Effectiveness of Metronidazole Gel and Mobile SMS Reminders on Gingivitis in Orthodontic Patients NCT03508999 | Aga Khan University | Phase 4 |
| Withdrawn | Evaluation of Two Active Lactobacilli for the Maintenance of Gingival Health NCT03291327 | Queen Mary University of London | N/A |
| Completed | A Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis NCT03936556 | Procter and Gamble | Phase 4 |
| Completed | Increased Knowledge Improve Oral Hygiene In Patients With Gingivitis NCT04643236 | Abant Izzet Baysal University | N/A |
| Completed | Functional Chewing Gum in Reduction of Gingival Inflammation NCT03237624 | University of Maryland, Baltimore | N/A |
| Completed | The Effects of Oscillating-Rotating Electric Toothbrushes on Plaque and Gingival Health NCT04017507 | Procter and Gamble | — |
| Completed | Efficacy of Philips Sonicare Flexcare Platinum Toothbrush® Compared to Manual Brushing in Healthy Patients: a NCT04558606 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Completed | Meta-analysis of Stannous Fluoride and the Effects on Gingival Health NCT03970759 | Procter and Gamble | — |
| Completed | Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis NCT03542630 | University of Zagreb | — |
| Completed | Powertoothbrushing for Treating Gingivitis NCT03381339 | Marquette University | N/A |
| Completed | Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis NCT03713567 | University of Campinas, Brazil | N/A |
| Completed | Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis NCT03219840 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population NCT02937636 | GlaxoSmithKline | N/A |
| Completed | Next Science Antimicrobial Mouth Rinse Study NCT03154021 | University of Florida | Phase 1 |
| Completed | Antiplaque, Antigingivitis and Anti-inflammatory Effects of Myrrh Mouthwash NCT04723732 | King Abdulaziz University | N/A |
| Unknown | Mouthwashes During Orthodontic Treatment NCT03179735 | University of Taubate | Phase 4 |
| Completed | The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Avai NCT03852056 | Colgate Palmolive | Phase 3 |
| Completed | The Efficacy of Full Mouth Erythritol Powder Air-Polishing Therapy (FM-EPAPT) Versus Traditional Ultrasonic De NCT04455269 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Completed | Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract NCT03474146 | Government College of Dentistry, Indore | N/A |
| Unknown | Dental Prophylaxis and Rheumatoid Arthritis NCT03087240 | University Hospital Heidelberg | N/A |
| Unknown | Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis NCT03142607 | Aga Khan University | Phase 3 |
| Completed | Effectiveness of the GumChucks® Flossing System Compared to String Floss for Interdental Plaque Removal in Chi NCT04057430 | University of California, Los Angeles | N/A |
| Completed | A Comparison of the Outcomes of Two Existing Routine Clinical Therapies for Dental Prophylaxis NCT03471325 | National University Health System, Singapore | N/A |
| Completed | Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis NCT02883244 | Sunstar Americas | N/A |
| Unknown | Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control NCT03099551 | Faculty Sao Leopoldo Mandic Campinas | Phase 4 |
| Unknown | Efficacy of Different Chlorhexidine Concentrations NCT02911766 | University of Oslo | Phase 4 |
| Completed | Hyaluronic Acid and Gingivitis in Pediatrics NCT03003858 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | — |
| Completed | Oral Gut Liver Axis in Cirrhosis NCT03030820 | Virginia Commonwealth University | N/A |
| Completed | Shifts in the Oral Biofilm of Patients With Known Oral Health Risk Factors NCT02885064 | University of North Carolina, Chapel Hill | — |
| Completed | Comparison of Two Interdental Cleaners NCT03047759 | All Sum Research Center Ltd. | N/A |
| Completed | Evaluation of the Addition of an Interdental Cleaning Device to Manual Brushing on Gingival Health NCT02836223 | Water Pik, Inc. | N/A |
| Completed | A Follow-Up Survey of Oral Hygiene and Health Outcomes for Women Previously Enrolled in "OHMOM" NCT02922010 | Procter and Gamble | — |
| Unknown | Clinical Effect of Lactobacillus Reuteri in Treatment of Gingivitis NCT02801773 | University of Chile | Phase 2 |
| Completed | Assessing the Effects of Three Oral Care Regimens NCT02940821 | Pearl Network | N/A |
| Completed | Health Impact of L.Reuteri Consumption in Crew Members of a Naval Ship at Sea NCT02775019 | Wuerzburg University Hospital | N/A |
| Completed | Efficacy of Electric 3D Versus Manual Toothbrushes in Patients With Fixed Orthodontic Appliances NCT02699931 | National and Kapodistrian University of Athens | N/A |
| Unknown | Clinical and Microbiological Effects of Lactobacillus Rhamnosus in Treatment of Gingivitis NCT02809313 | Jorge Gamonal | Phase 2 |
| Completed | SmartMouth Advanced Clinical Formula Clinical Research Design Protocol NCT02709785 | St. Louis University | N/A |
| Unknown | Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits NCT02958891 | Medical Corps, Israel Defense Force | — |
| Unknown | Frequency of Self-performed Mechanical Control of Plaque NCT02684682 | Universidade Federal de Santa Maria | N/A |
| Completed | Domiciliary Professional Oral Care for Dependent Elderly NCT02669979 | Karolinska Institutet | N/A |
| Completed | Intervention Study of Oral Health Education Programs Directed to Adolescents NCT02906098 | Göteborg University | N/A |
| Completed | Immunological and Regenerative Implications of Corrosion of Dental Materials NCT03334461 | University of Rijeka | Phase 2 |
| Completed | Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease NCT02750943 | GlaxoSmithKline | N/A |
| Completed | Essential Oil+ELA, Plaque and Gingivitis NCT02884817 | University of Oslo | Phase 4 |
| Completed | Effect of Toothpaste on the Reduction of Plaque and Inflammation NCT02552589 | Technische Universität Dresden | N/A |
| Completed | Effects on Tablets Containing Probiotic Candidate Strains NCT02633345 | University of Copenhagen | N/A |
| Completed | A Pilot Study to Evaluate a Molecular Method for Plaque NCT02574221 | Procter and Gamble | N/A |
| Completed | Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case NCT05146557 | University Ghent | — |
| Completed | "Safeguard Your Smile" an Oral Health Literacy Intervention Promoting Positive Oral Hygiene Self-care Behavior NCT02521155 | Université de Montréal | N/A |
| Completed | A Clinical Trial to Study the Effects of Two Home Made Mouthwashes in Patients With Gum Diseases NCT02546804 | Government College of Dentistry, Indore | N/A |
| Completed | A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifr NCT02543060 | Procter and Gamble | N/A |
| Completed | Improving Dental Floss Adherence and Gingival Health With SMS and an Innovative Floss Holder NCT03120559 | University of Lisbon | N/A |
| Completed | Randomized Trial of a Gum Health Formulation NCT03196648 | Glo Science, Inc. | N/A |
| Completed | Good Oral Health - A Bi-level Intervention to Improve Older Adult Oral Health NCT02419144 | UConn Health | N/A |
| Terminated | Rapid Point-of-Care Salivary Diagnostic for Periodontal Health NCT02403297 | Innovative Diagnostics Inc | — |
| Completed | Effectiveness of Black Tea Mouthwash on Plaque Formation NCT02545244 | Sri Hasanamba Dental College and Hospital | Phase 3 |
| Completed | Cervical Carious Lesions Restored With Calcium Silicate Based Cement (Biodentine) Compared With Glass-ionomer NCT03418246 | Jordan University of Science and Technology | N/A |
| Completed | Alcohol-free Essential Oils Containing Mouthrinse Efficacy on 3-day Supragingival Plaque Regrowth NCT02894593 | University of L'Aquila | N/A |
| Completed | A Clinical and Imaging Study to Evaluate a Novel Dentifrice NCT02271815 | University of California, Irvine | — |
| Unknown | Methodology Antiseptic Application, Influence on Oral Biofilm. NCT02267239 | University of Santiago de Compostela | Phase 4 |
| Completed | Effect of a Liquid Toothpaste on Periodontal Disease NCT03117153 | Dong-A Pharmaceutical | N/A |
| Completed | Nitrate Consumption and Gingival Inflammation NCT05866341 | Wuerzburg University Hospital | N/A |
| Completed | Assessment of a Probiotic to Treat Gingivitis in Pediatric Patients NCT01954849 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |