NCT07307144

Fractalkine-CX3CR1 Axis in Periodontal Therapy

Fractalkine and CX3CR1 Dynamics in Gingivitis and Periodontitis Before and After Therapy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Giresun University · Academic / Other
• Sex: All
• Age: 25 Years – 47 Years
• Healthy volunteers: Accepted

Summary

This study aimed to evaluate gingival crevicular fluid (GCF) levels of fractalkine/CX3CL1 and CX3CR1 in patients with gingivitis and periodontitis before and after non-surgical periodontal therapy.

Detailed description

Thirty stage 3 periodontitis, thirty gingivitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; gingivitis and periodontitis patients underwent non-surgical periodontal treatment, and GCF samples were collected at baseline and at 1 and 3 months after treatment. CX3CL1 and CX3CR1 were determined by ELISA.

Conditions

• Periodontitis
• Gingivitis
• Inflammation Biomarkers

Interventions

Type	Name	Description
OTHER	Non-surgical periodontal treatment	Scaling and root planing, oral hygiene education and motivation.

Timeline

• Start date: 2022-05-15
• Primary completion: 2023-11-15
• Completion: 2023-12-10
• First posted: 2025-12-29
• Last updated: 2025-12-29

Locations

1 site across 1 country: Turkey (Türkiye)