NCT06038812

Galectin Role in Periodontal Disease

Outcome of Non-surgical Periodontal Treatment on Gal-1 & Gal-3 GCF Levels in Periodontitis Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Fayoum University · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study aimed at exploring the effect of nonsurgical periodontal treatment on galectin 1 and 3 GCF levels in patients having gingivitis, periodontitis stage III compared to periodontally healthy individuals and if galectin-1 and -3 could serve as diagnostic markers and/or therapeutic targets for periodontitis, in addition to revealing their possible role in the periodontal disease. 45 systemically healthy participants were enrolled in this investigation, equally subdivided into three groups of 15 patients each: gingivitis, periodontitis (stage III) and control group with healthy gingiva. Probing depth, clinical attachment level, gingival and plaque index were registered. GCF levels of galectin-1 and -3 were evaluated in all included groups (before and after non-surgical treatment for periodontitis group) using enzyme linked immune-sorbent assay (ELISA) kit.

Conditions

• Gingivitis
• Periodontitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	GCF sample collection	collecting GCF from deepest sites by paper points
PROCEDURE	non-surgical periodontal treatment	performing scaling and root planning using ultrasonic device and manual curettes

Timeline

• Start date: 2023-08-01
• Primary completion: 2023-09-30
• Completion: 2023-09-30
• First posted: 2023-09-15
• Last updated: 2024-01-12

Locations

1 site across 1 country: Egypt