NCT07458464

A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the Mouth

A Clinical Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the Mouth as Compared to Colgate Cavity Protection Toothpaste.

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Colgate Palmolive · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The clinical study will examine the effects of brushing with randomly assigned test toothpaste on the bacteria on the dental plaque, tongue, cheek, gum surface, and in saliva

Detailed description

This parallel design clinical study will examine the effects of brushing with randomly assigned test toothpaste on the bacteria on the dental plaque, tongue, cheek, gum surface, and in saliva. The effects of the test toothpaste will be compared to a commercially available fluoride dentifrice that will serve as a control.

Conditions

• Plaque
• Gingivitis

Interventions

Type	Name	Description
DRUG	stannous fluoride toothpaste	toothpaste
DRUG	0.76% Sodium Monofluorophosphate (Na MFP) toothpaste	toothpaste

Timeline

• Start date: 2026-05-01
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2026-03-09
• Last updated: 2026-03-09

Regulatory

• FDA-regulated drug study