NCT06910397

The Effect of Probiotics on Gums Health and Bad Breath

Evaluating The Effect of Probiotics on Oral Health Status and Its Influence on The Gingival Disease and Halitosis in Iraq

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 88 (actual)
• Sponsor: Al-Mustansiriyah University · Academic / Other
• Sex: All
• Age: 17 Years – 25 Years
• Healthy volunteers: Accepted

Summary

the study is about using healthy bacteria to improve the overall gingival and overall health and prevent or decrease the bad odor of the mouth caused by bad bacteria

Detailed description

The goal of this study is to verify the effect of Probiotics on oral Health Status and eliminate the gingival disease and Halitosis by measuring the levels of salivary biomarkers (cytokine IL-1b and proteases Matrix metalloproteinase (MMP-8) in saliva) and level of volatile sulfur compounds (VSCs) and their effects on improving gingival diseases clinical parameters in person age of (17-25) years old. The participants are randomly divided into two parallel groups (A, B). Group A will take probiotics and group B will take placebo for 28 days. The levels of IL-1b, MMP-8 in saliva, and VSCs measurement will be recorded respectively in different intervals of zero time and repeated on 14 days and 28 days. Statistical analysis will be done then comparative between two groups

Conditions

• Gingivitis

Interventions

Type	Name	Description
DRUG	Probiotic Arm	one tablet daily for 28 days
OTHER	Placebo	placebo tablet once daily for 28 days

Timeline

• Start date: 2025-04-03
• Primary completion: 2025-05-03
• Completion: 2025-06-01
• First posted: 2025-04-04
• Last updated: 2025-08-11

Locations

1 site across 1 country: Iraq