NCT06892834

Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control.

A Three-month Clinical Study to Assess the Gingivitis Effect of Various Dentifrices.

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Procter and Gamble · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to evaluate the effect of two experimental hops extract-containing dentifrices on gingivitis relative to a positive control 0.454% SnF2 dentifrice and a negative control dentifrice after 12 weeks of product use.

Conditions

• Gingivitis

Interventions

Type	Name	Description
DRUG	Stannous Fluoride Dentifrice	Each subject will be randomly assigned to one of four treatment products and will be asked to brush 2x a day (1 minute per brushing) for 3 months.
DRUG	Sodium Fluoride Dentifrice	Each subject will be randomly assigned to one of four treatment products and will be asked to brush 2x a day (1 minute per brushing) for 3 months.
DRUG	Sodium monofluorophosphate dentifrice	Each subject will be randomly assigned to one of four treatment products and will be asked to brush 2x a day (1 minute per brushing) for 3 months.

Timeline

• Start date: 2025-03-25
• Primary completion: 2025-06-19
• Completion: 2025-06-19
• First posted: 2025-03-25
• Last updated: 2025-07-02

Locations

1 site across 1 country: Canada

Regulatory

• FDA-regulated drug study