NCT04032548

Effectiveness of Propolis Mouthwash on Gingivitis

Comparison of Effectiveness of Propolis Mouthwash on Gingivitis - Randomized Controlled Clinical Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Mahsa University · Academic / Other
• Sex: All
• Age: 20 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Mouthrinses have been in used for centuries as breath fresheners, medicaments, and antiseptics. Recently, propolis has caught the eyes of dentists worldwide and researches are being carried out to infuse the usage of propolis in the dental health care treatments. There is belief that propolis may have a role as a tooth decay prophylaxis and help heal oral ulcers. Propolis is used as mouthwash, toothpaste, oral gel, and throat lozenges because of its proclaimed antibacterial and anti-inflammatory properties. Propolis has shown activity against common periodontal microorganisms, such as Candida species and the Streptococci mutans in vitro studies. Till date, no study has evaluated the clinical and microbiological effects of Malaysian Propolis as a mouthwash. Thus, the present study is designed to evaluate the effectiveness of Propolis as a mouthwash in the reduction of Plaque and gingivitis.The aim of the study is to assess and compare the effectiveness of Propolis mouthrinse with Chlorhexidine mouthrinse.

Detailed description

The Randomized Controlled Clinical study with latin-square cross-over design would be used to assess and compare the effectiveness of Propolis and Chlorhexidine mouthrinse on gingivitis. Subjects with chronic generalized gingivitis with age group of 18-30 years will be selected for the study as the target population. Subjects who meet the inclusion and exclusion criteria will be selected and screened for the plaque and gingival status before including them in the study. They will be randomly divided into three groups. Group 1: 15 subjects (Placebo mouthwash) Group 2: 15 subjects (Propolis mouthwash) Group 3: 15 subjects (Chlorhexidine mouthwash)

Conditions

• Gingivitis

Interventions

Type	Name	Description
DRUG	Placebo mouthwash	After using mouthwash for 21 days, they are instructed to refrain from mouthwash for 14 days (wash out period).
DRUG	Propolis mouthwash	After using mouthwash for 21 days, they are instructed to refrain from mouthwash for 14 days (wash out period).
DRUG	Chlorhexidine mouthwash	After using mouthwash for 21 days, they are instructed to refrain from mouthwash for 14 days (wash out period).

Timeline

• Start date: 2019-02-18
• Primary completion: 2019-03-11
• Completion: 2019-06-05
• First posted: 2019-07-25
• Last updated: 2019-07-30

Locations

1 site across 1 country: Malaysia