NCT05268757

Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The present study is a double-blinded randomized clinical trial with a duration of 28 days.

Detailed description

The present study is a double-blinded randomized clinical trial with a duration of 28 days. 80 orally and systemically healthy participant will be allocated in the test (probiotic) and the control (placebo) group at baseline. The intervention is oral hygiene discontinuation, which will be applied at baseline and continue through day 14, followed by 14 days with regular oral care. Clinical measurements and sampling will be performed at baseline, day 14 and day 28 Primary endpoint: Changes in microbial composition. Secondary endpoints: Changes in clinical and immunological parameters

Conditions

• Gingivitis

Interventions

Type	Name	Description
BEHAVIORAL	Oral hygiene discontinuation	Oral hygiene discontinuation for 14 days followed by 14 days of regular oral care

Timeline

• Start date: 2022-01-05
• Primary completion: 2022-06-01
• Completion: 2022-06-01
• First posted: 2022-03-07
• Last updated: 2022-08-23

Locations

1 site across 1 country: Denmark