NCT05073393

Effect of Probiotics on Oral Homeostasis During Sugar Stress

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: University of Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The present study is a double-blinded randomized clinical trial with a duration of 28 days.

Detailed description

The present study is a double-blinded randomized clinical trial with a duration of 28 days. 80 orally and systemically healthy participant will be allocated in the test (probiotic) and the control (placebo) group at baseline. The intervention is sugar stress, which will be applied at baseline and continue through day 14, followed by 14 days without sugar stress. Clinical measurements and sampling will be performed at baseline, day 14 and day 28 Primary endpoint: Changes in microbial composition. Secondary endpoints: Changes in clinical and immunological parameters

Conditions

• Dental Caries
• Probiotics
• Gingivitis

Interventions

Type	Name	Description
BEHAVIORAL	Sugar stress	Sucrose rinsing for 14 days (8-10 times a day) followed by 14 days without sucrose rinsing

Timeline

• Start date: 2021-11-03
• Primary completion: 2021-12-17
• Completion: 2022-06-01
• First posted: 2021-10-11
• Last updated: 2022-08-23

Locations

1 site across 1 country: Denmark