NCT06627972

Asprosin Level in Individuals With Periodontal Disease

IS THERE A RELATIONSHIP BETWEEN PERIODONTAL CONDITION AND ASPROSIN LEVEL IN GINGIVAL CREVICULAR FLUID?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 75 (actual)
• Sponsor: Mustafa Kemal University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis and periodontitis.

Detailed description

This study is investigating the level of asprosin hormone in gingival crevicular fluid of patients with periodontal diseases such as gingivitis and periodontitis, and observing the healthy patient in terms of the hormone levels, as well. 75 volunteer patients aged 18-45 years old were included in this study. These patients were divided equally to three groups: Group I; periodontal health, Group II; gingivitis, Group III; periodontitis.The body fluids including serum, saliva and gingival crevicular fluid were collected from this participants according to the proper protocol and their storage was provided under certain conditions. ELISA tests for asprosin and Tumour necrosis factor alpha were made in laboratory. Also, clinical measurements such as plaque index, bleeding on probing, probing pocket depth were recorded at first visit day of the participants. The data were analysed according to the different periodontal conditions, and correlated with asprosin hormone and tumour necrosis factor alpha level in gingival crevicular fluid, serum and saliva.

Conditions

• Periodontitis
• Periodontal Health
• Gingivitis

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-07-31
• Completion: 2022-08-31
• First posted: 2024-10-04
• Last updated: 2024-10-04

Locations

1 site across 1 country: Turkey (Türkiye)