NCT04634201

Effect of Probiotics on the Periodontal Status of Orthodontic Patients

Effect of Probiotics in Addition to Dental Brushing on Gum Inflammation and Oral Microbiota in Patients With Fixed Orthodontic Appliances

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 116 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 12 Years – 16 Years
• Healthy volunteers: Not accepted

Summary

Gingival inflammation (gingivitis) is commonly reported in teenagers with fixed orthodontic devices (FOD). Indeed, FODs promote the accumulation of plaque and interfere with the efficacy of tooth brushing. According to in vitro and in vivo studies, the administration of oral probiotic bacteria including Lactobacillus reuteri may reduce the number of periodontal pathogens in saliva and dental plaque. A recent systematic review shows a positive effect of probiotics in addition to tooth brushing in the treatment of periodontitis. However, there is insufficient data regarding the effect of probiotics in the prevention of gum diseases. The aim of this double-blind randomized placebo-controlled study is to assess the effect of probiotics, in addition to dental brushing, on gum inflammation and the composition of the oral microbiota in teenagers with fixed orthodontic appliances

Conditions

• Periodontal Health
• Gingivitis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Oral probiotics (L. reuteri)	administration of probiotic containing tablets twice daily after tooth brushing for 3 months
DIETARY_SUPPLEMENT	Placebo	administration of a placebo twice daily after tooth brushing for 3 months

Timeline

• Start date: 2022-03-23
• Primary completion: 2026-03-01
• Completion: 2026-03-01
• First posted: 2020-11-18
• Last updated: 2025-12-23

Locations

1 site across 1 country: France