NCT06437925

Effects of Probiotic Ayran on Gingivitis

Effects of the Use of Probiotics Ayran on Gingival Inflammation: An Experimental Gingivitis Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Cukurova University · Academic / Other
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

Objectives: This study investigates the effects of daily consumption of probiotic ayran drink on gingival inflammation and the development of experimental gingivitis. Methods: A total of 54volunteer students were included in the present randomized, double-blind, placebo-controlled trial.The participants were divided randomly into two groups; The Control group consisted of 27 participants who consumed placebo ayran, while the 27 participants of the Test group consumed probiotic ayran (containing Lactobacillus acidophilus and Bifidobacterium bifidum) for 42 days twice a day.After 42 days, mechanical plaque control was interrupted for 5 days. The clinical parameters of gingivitis; Plaque index (PI), gingival index (GI), probing bleeding (BOP), probing depth (PPD) were recorded at baseline, day 42 (beginning of experimental gingivitis) and day 47 (the end of experimental gingivitis). At the same time points, gingival crevicular fluid had been collected for analysis of matrix metalloproteinase - 8 (MMP-8).

Detailed description

The most used and studied probiotics in the periodontal literature are lactobacillus and bifidobacterium. The current study aims to observe the effects of daily ayran consumption containing a probiotic combination of Lactobacillus acidophilus and Bifidobacterium bifidum on plaque development and gingival inflammation in an experimental gingivitis model of healthy individuals. The null hypothesis of this study using of probiotics has no additional benefit for periodontal health. This study evaluates the effects of daily consumption of ayran containing a probiotic combination of Lactobacillus Acidophilus and Bifidobacterium Bifidum on plaque development and gingival status in healthy individuals with experimental gingivitis.

Conditions

• Gingivitis
• Probiotics
• Inflamed Gums

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	probiotic ayran drink	The test group has received probiotic ayran drink for 6 weeks
DIETARY_SUPPLEMENT	Placebo ayran drink	The control group has received placebo ayran drink for 6 weeks

Timeline

• Start date: 2023-01-15
• Primary completion: 2023-04-15
• Completion: 2023-06-15
• First posted: 2024-05-31
• Last updated: 2024-05-31

Locations

1 site across 1 country: Turkey (Türkiye)