| Not Yet Recruiting | CHEER Oral Health in Pregnancy Study NCT07377344 | University of California, San Francisco | N/A |
| Not Yet Recruiting | Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodonta NCT07406867 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | — |
| Recruiting | Investigation of the Relationship Between Periodontitis and Sleep Quality NCT07421960 | Uskudar University | — |
| Not Yet Recruiting | Serum Inflammatory Protein Concentration During Dental Treatment NCT07468929 | Ohio State University | — |
| Recruiting | Adjunctive Diode Laser Therapy in Non-Surgical Periodontal Therapy NCT07446127 | Tel Aviv University | N/A |
| Recruiting | Association of Periodontal Status and Smoking With Salivary Inflammasome Markers NCT07312552 | Uskudar University | — |
| Recruiting | Oral-Spray Bacillus Spore Probiotics for Periodontal Disease Prevention and Supprotive Treatment in the Elderl NCT07258303 | Anabio R&D | N/A |
| Recruiting | Assessment of the Efficacy and Safety of OROXID® Oral Solution in Patients With Periodontitis NCT07257887 | ENIKAM d.o.o. | N/A |
| Recruiting | Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Respo NCT07262606 | Ömer Faruk Okumuş | N/A |
| Not Yet Recruiting | Periodontal Follow-up and Glycemy in Patients With Type 2 Diabetes NCT07165171 | Hospices Civils de Lyon | N/A |
| Active Not Recruiting | ABX Versus CHX in NSPT: a RCT NCT07520968 | University of Roma La Sapienza | N/A |
| Not Yet Recruiting | Digital Quantification of Dental Plaque Based on Intraoral Scanner Images NCT07152314 | University of Guarulhos | — |
| Completed | Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood Parameters NCT07069244 | Uskudar University | — |
| Recruiting | Lactoferrin-Based Oral Care for Periodontal Health in Pregnancy NCT07069140 | University of Pavia | N/A |
| Recruiting | Evaluation Of The Efficacy Of Subgingival Application Of Lovastatin Gel As An Adjunct To Non-Surgical Treatmen NCT07282756 | Medical University of Silesia | N/A |
| Not Yet Recruiting | Efficacy of Laser Therapy for Periodontitis NCT07013162 | University of Science and Technology, Yemen | N/A |
| Recruiting | Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy NCT07029360 | University of Pavia | N/A |
| Completed | Serum Chromium, Nickel, and Magnesium in Type 2 Diabetic Periodontitis NCT07327086 | Kahramanmaras Sutcu Imam University | — |
| Completed | Non-Surgical Periodontal Treatment With an Oscillating Ultrasonic Device With Adjunctive Root Polishing. A Ran NCT07469813 | 251 Hellenic Air Force & VA General Hospital | N/A |
| Recruiting | The Role of Granulation Tissue in Periodontal Regeneration NCT07254117 | Riga Stradins University | — |
| Completed | Nicotine Dependence, Periodontal Awareness, and Clinical Periodontal Parameters in Smokers With Gingivitis and NCT07457892 | Erzincan University | — |
| Active Not Recruiting | Longitudinal Oral Health Changes After Head and Neck Radiotherapy NCT07394842 | Ain Shams University | — |
| Not Yet Recruiting | Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis NCT06735313 | Necmettin Erbakan University | N/A |
| Active Not Recruiting | Effectiveness of Scaling and Root Planing in Deeper Pockets NCT06890689 | Texas A&M University | — |
| Active Not Recruiting | Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls NCT06897722 | Zhala Vatankha Sain | — |
| Completed | Impact of Atypical Swallowing on Periodontal Health in Adults NCT07534306 | University of Roma La Sapienza | — |
| Completed | Study on Biomarkers of Periodontitis and Type 2 Diabetes Mellitus in Males and Females 30 - 70 Years of Age NCT06582056 | Sanofi Pasteur, a Sanofi Company | N/A |
| Recruiting | Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Mate NCT06694168 | Universidad de los Andes, Chile | N/A |
| Completed | Method for Measuring Dental Mobility and Displacement Force NCT06600867 | University of Campinas, Brazil | N/A |
| Completed | Evaluation of Wnt5a and LRP5 Levels in Serum and Saliva Samples and the Relationship Between Clinical Periodon NCT06933784 | Ankara University | — |
| Completed | Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals Wi NCT06933797 | Ankara University | — |
| Recruiting | Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Impr NCT06890676 | Missouri Department of Health and Senior Services | N/A |
| Completed | Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers NCT07213752 | Selcuk University | N/A |
| Recruiting | Effect of Periodontal Treatment on Metabolic Control in Patients with Type-2 Diabetes Mellitus Treated in the NCT06895980 | University of Chile | N/A |
| Completed | Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a NCT06677736 | Rawda Saleh Saad Alashmawy | N/A |
| Unknown | Development of a Novel Anti-caries Chewing Gum NCT05946473 | University of Toronto | N/A |
| Completed | Gingival Crevicular Fluid and Salivary Levels of GDF-15, Smad2, Smad5, Smad6, and IL-6 in Patients With Period NCT07201142 | Melis Yilmaz | — |
| Completed | Assessment of Pentraxin Levels in the Gingival Fluid of Abutment Teeth in the Context of the Use of Fixed Dent NCT07271563 | Jagiellonian University | — |
| Completed | Probiotics And Ozonated Olive Oil To Maintain Oral Eubiosis In Stage I And II Periodontitis Patients NCT06955546 | Massimo Corsalini | N/A |
| Completed | Comparison of Saliva Biomarkers in Two Different Geographical Regions of Turkey NCT06809439 | Karabuk University | N/A |
| Completed | Effectiveness NutriDent4Mom to Improve Nutrient Intake, Diet Quality, and Periodontal Health Status of Pregnan NCT07247019 | NORKHAFIZAH SADDKI | N/A |
| Completed | Relationship Between Periodontal Disease and Postmenopausal Osteoporosis NCT07294105 | Recep Tayyip Erdogan University | — |
| Active Not Recruiting | Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of NCT06920849 | Medical University of Bialystok | N/A |
| Completed | Healing of Intrabony Defects Following Treatment With PRF or EMD NCT07183631 | Semmelweis University | Phase 4 |
| Recruiting | Myocardial Infarction and Periodontitis: Periodontal Health Intervention. NCT06745141 | Shanghai 10th People's Hospital | N/A |
| Completed | Functional Validation of Lactobacillus Containing Oral Tablet NCT04873505 | National Cheng-Kung University Hospital | N/A |
| Completed | Periodontal Status and Cytokine Levels in Patients With Non-Infectious Uveitis NCT07480291 | Selcuk University | — |
| Completed | Evaluation of Gingival Health Parameters in Hybrid CAD / CAM Crowns Produced After Different Retraction Proces NCT03816930 | Yuzuncu Yil University | N/A |
| Completed | Estimation of Sialic Acid and IL10 Levels in Stage 1 and 2 Periodontitis Patients NCT03775967 | Ajman University | — |
| Completed | Topical Metronidazole vs Control in Reducing Periodontal Pockets in a Split Mouth Clinical Trial NCT06836401 | University of Salamanca | Phase 4 |
| Completed | Correlation Between Oral Health and Systemic Inflammation (COHESION) NCT03641989 | Marshfield Clinic Research Foundation | N/A |
| Unknown | Response to Periodontal Therapy in a Chronic Kidney Disease Population NCT03525457 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Serum Hs-CRP in Periodontitis Patients With or Without Diabetes NCT03908606 | Cairo University | N/A |
| Unknown | Evaluation of the Possible Relationship Between Preeclampsia and Periodontal Disease NCT03603236 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Unknown | Evaluation of the Possible Relationship Between Periodontal Disease and Preterm Labor NCT03610841 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Withdrawn | The Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient NCT02202304 | Rosa Moreno Lopez | Phase 4 |
| Withdrawn | Dental Engagement Study Behavior Modification NCT02749318 | Interleukin Genetics, Inc. | N/A |
| Completed | Dental and Periodontal Health in Obese Adolescents: Clinical, Biochemical, and Microbiological Evaluation NCT07086027 | Marmara University | — |
| Completed | Tooth Extraction in Patients With Atrial Fibrillation in Use of New Oral Anticoagulants NCT03181386 | University of Sao Paulo General Hospital | Phase 3 |
| Completed | Providing Preventive Periodontal Treatment to Hospitalized Patients With Diabetes NCT02914743 | Massachusetts General Hospital | N/A |
| Completed | Study of Colonization of Strains L.Plantarum and L.Brevis in the Product AB-DENTALAC Chewing Gum NCT03540498 | AB Biotics, SA | N/A |
| Completed | Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis NCT02794012 | University of Colorado, Denver | — |
| Unknown | The Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing NCT02826109 | University of British Columbia | Phase 4 |
| Completed | Preventive Maintenance Therapy on Peri-implant Diseases NCT02789306 | Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain | — |
| Completed | Safety, Efficacy and Treatment Regimen Study of ST266 in Subjects With Moderate to Severe Periodontitis NCT02761993 | Noveome Biotherapeutics, formerly Stemnion | Phase 2 |
| Unknown | PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke NCT02541032 | University of South Carolina | Phase 3 |
| Unknown | Evaluation of Periodontal Treatment in Patients With Bronchiectasis NCT02514226 | University of Nove de Julho | N/A |
| Unknown | Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy NCT02581319 | University of Sao Paulo | N/A |
| Completed | Endocan, VEGF and TNF-alpha Levels in Periodontal Disease and After Treatment NCT02750956 | Bulent Ecevit University | — |
| Completed | Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodo NCT02670135 | Colgate Palmolive | Phase 4 |
| Completed | Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi NCT02333227 | Baylor College of Medicine | N/A |
| Terminated | Rapid Point-of-Care Salivary Diagnostic for Periodontal Health NCT02403297 | Innovative Diagnostics Inc | — |
| Completed | Study Aimed at Detecting Potential Abuse of Nitrous Oxide in Children During Dental Care NCT02894463 | Nantes University Hospital | — |
| Completed | Towards a Viral Etiology of Periodontal Disease in Relation to Radiotherapy Treatment of Head and Neck Cancers NCT02180932 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | The Effects of Obesity on Non Surgical Periodontal Therapy NCT02618486 | University of Malaya | N/A |
| Completed | Observational Study of the Association Between Periodontal Disease and Cardiovascular Disease NCT02177591 | Texas Tech University Health Sciences Center | — |
| Unknown | Metabolic Syndrome and Periodontitis NCT02012842 | Federal University of Rio Grande do Sul | N/A |
| Completed | Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease NCT02848378 | Kırıkkale University | — |
| Completed | Randomized Controlled Trial of a Novel Laser-aided Orthodontic-periodontal Treatment Strategy NCT02352038 | The University of Hong Kong | N/A |
| Unknown | Periodontal and Cardiometabolic Responses to Vitamin D Intervention in African Americans With Periodontal Dise NCT02337257 | Augusta University | EARLY_Phase 1 |
| Completed | Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials. NCT03227367 | Meenakshi Ammal Dental College and Hospital | N/A |
| Completed | Kidney and Periodontal Disease Study NCT01802216 | University of California, San Francisco | N/A |
| Unknown | Correlation Between Inflammatory Markers in Gingival Crevicular Fluid, Serum and Amniotic Fluids in Periodonta NCT02022865 | Hadassah Medical Organization | — |
| Unknown | Polymorphonuclear Cells' Sensitivity to Aggregatibacter Actinomycetemcomitans Bacteria in Patients With Aggres NCT02010307 | Polak David | N/A |
| Completed | Porous and Non-porous Bone Grafts in Intra-bony Periodontal Defects NCT02463006 | Dr. D. Y. Patil Dental College & Hospital | Phase 2 / Phase 3 |
| Completed | Impact of Periodontal Disease on Outcomes in Diabetes NCT02289066 | University of Nevada, Reno | — |
| Completed | Periodontal Disease Treatment of a Physically Challenged Population NCT01718912 | Oravital Inc | N/A |
| Completed | Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus NCT03444363 | Çanakkale Onsekiz Mart University | N/A |
| Completed | "Study of Halitosis in Patients With Advanced Chronic Periodontitis" NCT02368678 | Federal University of Minas Gerais | N/A |
| Completed | EMD and/or Bone Substitute for the Treatment of Class II Furcations NCT02474498 | University of Campinas, Brazil | Phase 4 |
| Completed | Evaluation and Comparison of the Efficacy of Triphala Mouthwash and 0.2% Chlorhexidine NCT01900535 | Tatyasaheb Kore Dental College | — |
| Completed | Relationship Between Obesity and Periodontal Disease NCT02508415 | University of Malaya | N/A |
| Completed | Bacterial Arrangement on the Teeth NCT01712672 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection NCT02126267 | Centro Universitario de Lavras | N/A |
| Recruiting | Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis) NCT01568697 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Power Toothbrush Use in Nursing Homes to Eliminate Mouth and Body Inflammation NCT01639183 | University of Manitoba | N/A |
| Unknown | The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients NCT01785355 | Anemia Working Group Romania | — |
| Completed | Characterizing Gingival and Periodontal Ligament Fibroblasts Reaction to Infection With the Bacteria Porphyrom NCT01599091 | Hadassah Medical Organization | — |
| Completed | Periodontal Treatment Response in Type II Diabetic Patients NCT01881074 | University of Florida | — |
| Completed | Periodontal Disease and Post-menopausal Osteoporosis NCT02184962 | Universidad Nacional de Córdoba | — |
| Completed | A Comparison Between the Repeatability of Probing Pocket Depths Achieved With Manual and Automated Periodontal NCT01622192 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | Oral Health in Breast Cancer Survivors on Aromatase Inhibitors NCT01693731 | University of Michigan | — |
| Completed | Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matr NCT02102360 | University of Sao Paulo | Phase 4 |
| Completed | Biomarkers of Periodontal Disease Progression NCT01489839 | The Forsyth Institute | — |
| Unknown | Genetics of Periodontal Diseases in Chinese (Taiwan) NCT01675336 | Kaohsiung Medical University | — |
| Completed | The Importance of Periostin in Periodontal Health and Disease NCT01180920 | University of Michigan | — |
| Completed | Photodynamic Therapy and Periodontal Therapy. A Clinical, Microbiological and Immunoenzymatic Analysis NCT01670305 | Paulista University | N/A |
| Completed | Periodontal Treatment and Metabolic Control in Type 2 Diabetic Patients NCT01291875 | University of Sao Paulo | N/A |
| Completed | Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults NCT01376791 | San Diego State University | — |
| Completed | Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis NCT01156155 | University of Nebraska | — |
| Completed | The Effect of Non-Surgical Periodontal Therapy on Glycemic Control and Bacterial Levels in a Mexican-American NCT01128374 | The University of Texas Health Science Center, Houston | N/A |
| Completed | Microbes and Bariatric Surgery NCT01130207 | State University of New York - Upstate Medical University | — |
| Completed | Pediatric Study to Access Pharmacokinetics and Safety of Oraqix Gel NCT01591616 | Dentsply International | Phase 4 |
| Completed | Comparison Between aPDT and Systemic Doxycycline on Non-surgical Periodontal Therapy in Type 2 Diabetics NCT01595594 | University of Sao Paulo | Phase 3 |
| Completed | Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. NCT02487186 | University of Campinas, Brazil | Phase 4 |
| Completed | Periodontal Disease and Circulatory Microbial Components NCT01154855 | University of Michigan | — |
| Completed | Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA) NCT01198509 | NYU Langone Health | N/A |
| Completed | Omega-3 and Aspirin in Periodontal Regeneration NCT01113528 | October 6 University | Phase 2 |
| Completed | Implant Surface Decontamination in Peri-implantitis Treatment NCT01521260 | University Medical Center Groningen | N/A |
| Completed | Interaction Between Chlorhexidine and Fluoride NCT02935322 | University of Oslo | Phase 4 |
| Terminated | Prospective Study of the Influence of Periodontal Diseases on Pre-term Birth: Observation in the Maternity Hos NCT00982813 | Nantes University Hospital | N/A |
| Completed | Association of Periodontitis and Preeclampsia During Pregnancy NCT00855504 | Maulana Azad Medical College | — |
| Completed | Dentin Hypersensitivity Following Non-surgical Periodontal Therapy With Hand or Ultrasonic Instruments NCT01427764 | Escola Bahiana de Medicina e Saude Publica | N/A |
| Completed | Relationship Analysis Between Periodontal Disease and Atherosclerosis in Japanese Medical Cooperation Services NCT01866761 | Okayama University | — |
| Completed | Treatment for Periodontal Disease in Dialysis Patients NCT00937976 | University of North Carolina, Chapel Hill | N/A |
| Completed | Immunoregulation of Periodontal Disease NCT00702429 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Study on Regenerative Treatment of Intra-bony Defects NCT00757159 | Technische Universität Dresden | Phase 4 |
| Completed | Influence of Periodontal Treatment on Systemic Inflammatory Mediators NCT01201746 | Sheikh Zayed Federal Postgraduate Medical Institute | N/A |
| Withdrawn | Effect of Actonel on Periodontal Health of Postmenopausal Women NCT00594334 | University Hospitals Cleveland Medical Center | Phase 4 |
| Completed | Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population NCT01798225 | Medical University of South Carolina | Phase 4 |
| Completed | Epigenetics, DNA Methylation Patterns and Periodontal Disease NCT01399034 | University of North Carolina, Chapel Hill | — |
| Unknown | The Relation Between Periodontal Disease and Metabolic Syndrome NCT00553007 | Aichi Gakuin University | N/A |
| Completed | Periodontal and Periapical Inflammation and Pregnancy NCT00490165 | Roger Johnson | — |
| Completed | Effects of Periodontal Therapy on Systemic Inflammation NCT01046435 | University of Chile | N/A |
| Completed | The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in Diabetics NCT00763256 | Colgate Palmolive | Phase 3 |
| Completed | Changes in Inflammatory State in Asian Americans Changing From Traditional Asian Diets to American Diet - a Pi NCT00379548 | Joslin Diabetes Center | N/A |
| Withdrawn | Periodontal Disease and Preterm Birth NCT00582374 | University of Oklahoma | — |
| Completed | Impact of Gum Infection on Heart Disease NCT00093236 | Boston University | N/A |
| Completed | Photodynamic Lasertherapy (PDT) in Periodontal Treatment (in Vivo) NCT00196456 | University Medicine Greifswald | Phase 2 |
| Unknown | Effects of Periodontal Pathogens, Porphyromonas Gingivalis and Tannerella Forsythensis, on Cytokine Production NCT00162838 | National Taiwan University Hospital | — |
| Unknown | Norplant and Irregular Bleeding/Spotting NCT00064766 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 4 |
| Completed | Periodontal Treatment Associated With Hyperbaric Oxygen Therapy NCT00955643 | Escola Bahiana de Medicina e Saude Publica | N/A |
| Completed | Treating Periodontal Infection: Effects on Glycemic NCT00016835 | University of Michigan | Phase 2 |
| Completed | Influence of Periodontal Treatment During Pregnancy in Adverse Pregnant Outcomes NCT00893802 | University of Sao Paulo | N/A |
| Completed | Study of the Composition of Dental Plaque NCT00001726 | National Institute of Dental and Craniofacial Research (NIDCR) | — |
| Completed | Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect o NCT00001698 | National Cancer Institute (NCI) | Phase 2 |
| Completed | "Clinical Trials to Enhance Elders' Oral Health" ("TEETH") NCT00004640 | University of Washington | Phase 3 |