NCT06933797

Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis

Evaluation of the Changes in LRP5 and TPH1 Levels Due to Periodontal Inflammation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Ankara University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values and clinical periodontal parameters. Methods: Saliva and serum samples were collected from 20 systemically healthy patients with Stage III periodontitis and 20 periodontally healthy control individuals. Salivary and serum LRP5 and TPH1 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Clinical periodontal parameters, including plaque index (PI), probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level (CAL), were recorded.

Conditions

• Periodontal Disease
• Periodontitis (Stage 3)
• Periodontitis Stage III

Timeline

• Start date: 2024-04-01
• Primary completion: 2024-10-01
• Completion: 2025-02-25
• First posted: 2025-04-18
• Last updated: 2025-04-18

Locations

1 site across 1 country: Turkey (Türkiye)