NCT05946473

Development of a Novel Anti-caries Chewing Gum

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Toronto · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.

Detailed description

The goal of this project is to develop a pre-biotic chewing gum that is designed to promote a healthy oral microbiome. The gum will contain compounds that will: a) be unable to be converted to acids; b) target the cariogenic S. mutans population; c) promote the stability of a healthy environment by modulating plaque pH via base-generating compounds; d) promote tooth remineralization by increasing saliva flow and by addition of calcium phosphate.

Conditions

• Dental Plaque
• Dental Caries
• Periodontal Disease

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Gum base containing xylitol and essencial oils	Participants will be asked to chew 2 pieces of chewing gum containing additives for 10 minutes after eating in the morning, and after one meal in the evening, for a four-week period
DIETARY_SUPPLEMENT	Gum base with no additives	Participants will be asked to chew 2 pieces of pure gum base for 10 minutes after eating in the morning, and after one meal in the evening, for a four-week period

Timeline

• Start date: 2023-07-01
• Primary completion: 2023-12-01
• Completion: 2024-04-01
• First posted: 2023-07-14
• Last updated: 2023-07-14