NCT01156155

Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 617 (actual)
• Sponsor: University of Nebraska · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Accepted

Summary

Periodontitis (PD) has been postulated to be a risk factor for the onset and progression of rheumatoid arthritis (RA). Recent reports suggest that infection with Porphyromonas gingivalis (P. gingivalis), a major oral pathogen in PD, could play a pivotal role in the development RA. The objective of this study is to examine the relationship of PD and P. gingivalis infection with the risk and severity of RA.

Detailed description

In this study, we will examine whether periodontitis (PD) and P. gingivalis impact rheumatoid arthritis (RA) risk by enrolling 300 patients with RA and 300 comparator patients with osteoarthritis and comparing results from comprehensive dental examinations and antibody responses to P. gingivalis. We will examine whether these associations are modified by the presence of certain genetic risk factors previously implicated in RA and whether evidence of infection with P. gingivalis precedes RA onset by examining banked sera from the Department of Defense Serum Repository (DoDSR) and the Studies of the Etiology of RA (SERA). We also plan to explore whether there are novel proteins expressed by P. gingivalis that drive autoimmunity in RA and whether immune responses to these bacterial proteins predict the future development of RA.

Conditions

• Rheumatoid Arthritis
• Osteoarthritis
• Periodontal Disease

Interventions

Type	Name	Description
RADIATION	Digital xray of jaw and teeth	one time xray of jaw and teeth
PROCEDURE	Blood draw	Three to four tablespoons of blood drawn.
OTHER	questionnaires	completed questionnaires regarding patient's health and functional ability.
PROCEDURE	Periodontal Examination	Periodontal examination including measurement of gum pockets with a probe. Bacterial samples taken.
OTHER	Bilateral digital xray of hands	One time digital xray of hands

Timeline

• Start date: 2010-07-14
• Primary completion: 2018-08-30
• Completion: 2018-08-30
• First posted: 2010-07-02
• Last updated: 2023-11-02

Locations

1 site across 1 country: United States