| Withdrawn | Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement NCT02217202 | Golden Jubilee National Hospital | N/A |
| Withdrawn | Genicular Embolization Using Doxycycline Sclerotherapy NCT07024654 | Campbell Clinic | Phase 2 |
| Not Yet Recruiting | The Safety and Efficacy of XytriX (Umbilical Cord-Derived Mesenchymal Stem Cells) in the Treatment of Knee Ost NCT07487766 | TricelX Inc. | Phase 1 / Phase 2 |
| Not Yet Recruiting | Synovial Tissue as a Biomarker in the Early Management of Osteoarthritis NCT07473414 | Nantes University Hospital | N/A |
| Recruiting | Clinical Trial on the Efficacy and Safety of ALT001 in Osteoarthritis NCT07404891 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | N/A |
| Not Yet Recruiting | Clinical, Microbial and Tissue-based Characterization of Patients Treated for Severe Temporomandibular Joint P NCT07350239 | Örebro University, Sweden | — |
| Recruiting | Arthrosemid vs. Steroid for the Management Knee Osteoarthritis NCT07489521 | Cappagh National Orthopaedic Hospital | Phase 4 |
| Not Yet Recruiting | Ketogenic Diet to Reduce Osteoarthritis Pain in MCI NCT07417891 | University of Kansas Medical Center | N/A |
| Recruiting | Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or O NCT07353931 | Eli Lilly and Company | Phase 3 |
| Recruiting | A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System NCT07118501 | Stryker Trauma and Extremities | — |
| Not Yet Recruiting | GLP1 Analogues and the Risk of Osteoarthritis NCT07360457 | Beni-Suef University | — |
| Withdrawn | Stromal Vascular Fraction (SVF) for Knee Post-Trauma Osteoarthritis (PTOA) NCT05515523 | Wake Forest University Health Sciences | EARLY_Phase 1 |
| Recruiting | Activating SilverSneakers Benefits for Seniors With Osteoarthritis NCT06782347 | Milton S. Hershey Medical Center | N/A |
| Not Yet Recruiting | A Study on Rosa Roxburghii for Knee Replacement Recovery NCT07395856 | Shuguang Gao | N/A |
| Recruiting | The Effectiveness of a Herbal Supplement in Osteoarthritis. NCT07324746 | Middlesex University | N/A |
| Recruiting | Efficacy of Two Ultrasound-guided Intra-articular Injections of Botox® Combined With Custom-made Rigid Splinti NCT06902805 | Assistance Publique - Hôpitaux de Paris | Phase 2 / Phase 3 |
| Not Yet Recruiting | Phase 4 Study of Laybon Tab. in Knee Osteoarthritis NCT07203547 | Mather's Pharm. Co., Ltd. | Phase 4 |
| Not Yet Recruiting | Clinical Investigation of Sensovisc Sterile Sodium Hyaluronate Gel NCT07232199 | Ankara City Hospital Bilkent | N/A |
| Recruiting | EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN)) NCT06631638 | DePuy Orthopaedics | N/A |
| Recruiting | Generative AI Impact on Rheumatoid Arthritis Complications Diagnosis NCT07301892 | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | — |
| Not Yet Recruiting | Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas. NCT07173335 | University of Sydney | N/A |
| Not Yet Recruiting | Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthropl NCT07030049 | Clinique Trenel | N/A |
| Not Yet Recruiting | Mass Spectrometry-based Immune Profiling in Autoimmune Diseases NCT07188285 | Peking University People's Hospital | — |
| Recruiting | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the NCT07153471 | Eli Lilly and Company | Phase 3 |
| Recruiting | "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthri NCT07198750 | Hospital Civil de Guadalajara | N/A |
| Not Yet Recruiting | Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoart NCT07151300 | Sinai University | N/A |
| Not Yet Recruiting | Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test NCT07158892 | University of Texas at Austin | N/A |
| Active Not Recruiting | Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) NCT07006714 | University of Miami | Phase 4 |
| Recruiting | A Mobile Intervention to Reduce Pain and Improve Health-III NCT06623669 | Wake Forest University | Phase 2 |
| Recruiting | Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy NCT06965452 | Northwell Health | N/A |
| Not Yet Recruiting | Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam NCT06487819 | Al-Azhar University | N/A |
| Not Yet Recruiting | A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches NCT07085520 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 1 |
| Recruiting | Feasibility of Choose to Move Replacement Ready NCT07069179 | University of British Columbia | N/A |
| Completed | The Efficacy of Nutrilite All-plant Protein Booster to Improve Sarcopenia and Osteoarthritis in Middle-aged an NCT06499012 | Amway (China) R&D Center | N/A |
| Recruiting | Long-Term Study of CartiPRO for Knee Pain Due to Osteoarthritis or Cartilage Damage NCT07267793 | DALIM TISSEN Co., Ltd. | N/A |
| Not Yet Recruiting | Effectiveness of Stromal Vascular Fraction (SVF) and Platelet -Rich Plasma (PRP) in Patients With Knee Osteoar NCT05660824 | Adrien Schwitzguebel | Phase 4 |
| Not Yet Recruiting | A Population-based Cohort of Osteoarthritis: the Tsinghua University Tiantongyuan Community Osteoarthritis Stu NCT07006701 | Beijing Tsinghua Chang Gung Hospital | — |
| Not Yet Recruiting | A Multi-Center Study on the Clinical Advantages of Personalized Total Knee Arthroplasty System NCT07003035 | YujiakuoTHU | — |
| Not Yet Recruiting | A Multi-Center Bidirectional Cohort Study on Total Knee Arthroplasty for the Treatment of Knee Osteoarthritis NCT06990594 | Beijing Tsinghua Chang Gung Hospital | — |
| Enrolling By Invitation | Efficacy Test of Curcuminoid Standardized Turmeric Capsules to Improving Inflammatory Biomarkers in Osteoarthr NCT07183215 | Gadjah Mada University | Phase 2 / Phase 3 |
| Recruiting | The Beat Pain Better Trial NCT06932887 | University of Utah | Phase 3 |
| Not Yet Recruiting | Prospective Evaluation Assessing U2 MB™ Total Knee System NCT06996158 | MSK Doctors & Associates Ltd | — |
| Recruiting | An Study to Evaluate Safety and Tolerability of OA-SYS in Subjects With Moderate to Severe Osteoarthritis of t NCT06485843 | Ageless Biotech, Inc. | Phase 2 |
| Recruiting | Antigravity Treadmill After Joint Arthroplasty NCT07040878 | Wroclaw University of Health and Sport Sciences | N/A |
| Recruiting | The PROACTIVE Study for Black Elders NCT06512727 | University of Florida | N/A |
| Not Yet Recruiting | Cellular and Molecular Analysis of Synovial Tissue of Patients With Arthritis NCT06737952 | University Hospital, Basel, Switzerland | — |
| Recruiting | Ultra Processed Foods Consumption and Impact in Rheumatic Diseases. NCT06776965 | Hospices Civils de Lyon | — |
| Recruiting | Retro-walking Versus Forward-walking Training Using Underwater Treadmill in Patients With Knee Osteoarthritis NCT06896032 | Nourhan Atwa Said | N/A |
| Completed | Platelet Rich Plasma Combined With Platelet Rich Fibrin in Management of Temporomandibular Joint Osteoarthriti NCT06573502 | Aliaa Babekir Ahmed Mohamed | N/A |
| Recruiting | Dose Response of Exercise for Arthritis Management NCT06880653 | University of South Carolina | N/A |
| Completed | Anti-Inflammatory Effects Of Frequency Specific Microcurrent (FSM) In Osteoarthritic Adults NCT06390137 | Nova Southeastern University | N/A |
| Recruiting | Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department NCT06603662 | WellSpan Health | Phase 4 |
| Recruiting | Kinematic and Mechanical Alignment Randomized Trial NCT06787417 | McMaster University | Phase 4 |
| Recruiting | Clinical Study of Acupuncture Treatment of Knee Osteoarthritis NCT06805188 | Wu zenan | N/A |
| Recruiting | Physical Activity Promotion in Osteoarthritis Patients NCT06385028 | Luxembourg Institute of Health | N/A |
| Not Yet Recruiting | Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic an NCT06709703 | Université de Sherbrooke | N/A |
| Recruiting | Evaluation of the Safety of LipiodolⓇ Embolization in Symptomatic Digital Osteoarthritis Refractory to Convent NCT06611007 | University Hospital, Grenoble | Phase 1 / Phase 2 |
| Active Not Recruiting | Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients NCT06778486 | University of California, Davis | N/A |
| Enrolling By Invitation | Effect of Semiconductor Embedded Therapeutic Gloves for Hand Osteoarthritis NCT06744855 | Altoona Center for Clinical Research | N/A |
| Completed | Effect of Genicular Nerve Block on Proprioception in Knee Osteoarthritis NCT06744842 | Ankara City Hospital Bilkent | N/A |
| Completed | Thumb Muscle Thickness and Strength in CMC Osteoarthritis NCT06730698 | Beylikduzu State Hospital | — |
| Not Yet Recruiting | Effect of Exercise Type on Muscle Quality in Patients With OA, SARC and RA: an Explorative Study NCT06480643 | Amsterdam UMC, location VUmc | N/A |
| Recruiting | ARVIS TKA vs Conventional TKA NCT06663384 | Foundation for Orthopaedic Research and Education | N/A |
| Not Yet Recruiting | A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus. NCT06707948 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | — |
| Active Not Recruiting | SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization NCT06550024 | CrannMed | N/A |
| Recruiting | Investigation of the Cultural Adaptation, Validity, and Reliability of the Turkish Version of the CAP Question NCT06825650 | Hacettepe University | — |
| Completed | A First-in-human Study to Investigate Safety and Tolerability of SAR446959 in Participants With Osteoarthritis NCT06704932 | Sanofi | Phase 1 |
| Recruiting | Assessing Central Aspects of Pain NCT06518278 | University of Nottingham | — |
| Recruiting | The Effectiveness of Heat Treatment on Knee Pain in Patients With Osteoarthritis - an International, Multicent NCT06650631 | Aziende Chimiche Riunite Angelini Francesco S.p.A | N/A |
| Recruiting | Amniotic Suspension Allograft Injection for Knee Osteoarthritis NCT06704893 | Chang Gung Memorial Hospital | Phase 3 |
| Recruiting | Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain NCT06514755 | Zagazig University | N/A |
| Active Not Recruiting | A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary H NCT06564636 | Smith & Nephew, Inc. | — |
| Completed | Exercise Impact in Elderly With Multimorbidity: HbA1c and Blood Pressure NCT06879639 | Universidade do Porto | N/A |
| Not Yet Recruiting | A Randomized Controlled Trial of the Sagittal Alignment Difference Between Mako Robotic TKA and Manual TKA NCT06527911 | Chinese PLA General Hospital | — |
| Completed | Physiological Impact of Different Types of Osteoarthritis Education. NCT06400329 | Lisa Carlesso | N/A |
| Not Yet Recruiting | The Relationship Between Serum Chemokine Ligand 21 (CCL-21) Level and Disease Activity NCT06540573 | Gaziosmanpasa Research and Education Hospital | — |
| Not Yet Recruiting | Vitamin D With Omega-3 or Metformin in Osteoarthritis NCT06328426 | Assiut University | N/A |
| Enrolling By Invitation | Balneotherapy and Peloid Therapy Impact Small Joint Diseases NCT06477393 | Lithuanian University of Health Sciences | N/A |
| Not Yet Recruiting | An Bioequivalence Study of Loxoprofen Sodium Patches in Healthy Volunteers NCT06510413 | Frontier Biotechnologies Inc. | Phase 1 |
| Completed | The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in P NCT07015879 | Cyprus International University | N/A |
| Not Yet Recruiting | Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Oste NCT06404606 | Pakistan Society for Rehabilitation of Differently Abled Hospital | N/A |
| Recruiting | Platelet Rich Plasma Injections In Young And Old Human Subjects NCT06451120 | University of California, San Francisco | Phase 2 |
| Completed | Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthri NCT06263270 | Cytonics Corporation | Phase 1 |
| Completed | Effects of Ultrasound-guided Genicular Nerve Block in Knee Osteoarthritis Patients on Proprioception and Stati NCT06527651 | Ankara City Hospital Bilkent | N/A |
| Recruiting | Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty NCT06426251 | National Taiwan University Hospital Hsin-Chu Branch | N/A |
| Recruiting | Intra-articular Corticosteroid With Hyaluronic Acid Plus Physiotherapy for Hip Pathologies (NON-OP HIP) NCT06653985 | ArthroBiologix Inc. | N/A |
| Recruiting | Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA NCT06328062 | Thammasat University Hospital | N/A |
| Not Yet Recruiting | Investigating Medical Research Trends in Osteoarthritis Clinical Trials NCT05811858 | Power Life Sciences Inc. | — |
| Recruiting | Migraine and Neuropathic Pain in Osteoarthritis NCT06224959 | University Hospital, Clermont-Ferrand | — |
| Active Not Recruiting | Investigation of the Effectiveness of Short Wave Diathermy Treatment in Patients With Hand Osteoarthritis NCT06739096 | Omer Sezgin | N/A |
| Enrolling By Invitation | WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis NCT06946329 | University of Sistan and Baluchestan | N/A |
| Active Not Recruiting | From Perception to Performance: A Comprehensive Evaluation in Knee Osteoarthritis. NCT07417033 | Lokman Hekim University | — |
| Completed | A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthriti NCT05337540 | Aptissen SA | N/A |
| Completed | Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis NCT06329492 | Mayo Clinic | Phase 1 / Phase 2 |
| Completed | First in Human Study of SakuraBead for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteoarth NCT06718478 | CrannMed | N/A |
| Terminated | Temporary Peripheral Nerve Stimulation System for Osteoarthritis of the Knee NCT06152029 | Wake Forest University Health Sciences | — |
| Recruiting | Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Knee Degenerative Osteoart NCT05917028 | Next Biomedical Co., Ltd. | N/A |
| Completed | Pericapsular Nerve Group Block Chemical Neurolysis in Advanced Hip Osteoarthritis NCT06087588 | Poznan University of Medical Sciences | Phase 4 |
| Completed | The Impact of Genicular Nerves Chemical Neurolysis on the Quality of Life of Patients with Advanced Knee Osteo NCT06087601 | Poznan University of Medical Sciences | Phase 4 |
| Unknown | Muscles Strength and Gait Parameteres After TKA NCT06061367 | Medical University of Warsaw | — |
| Unknown | Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline NCT06070818 | The University of New South Wales | N/A |
| Unknown | A Qualitative Investigation of CLEAT Participants NCT05937542 | Bournemouth University | — |
| Terminated | MDR - Longevity IT Oblique and Offset Liners NCT05980234 | Zimmer Biomet | — |
| Completed | Effect of Whole Body Vibration Therapy on Pain, Muscle Strength, Balance and Quality of Life in Knee Osteoarth NCT06542692 | Burak Çetinkaya | N/A |
| Completed | Evaluation of the Relationship Between Muscle Architecture and Muscle Strength in Female Gonarthrosis Patients NCT06003413 | Bezmialem Vakif University | — |
| Unknown | Efficacy of Probiotics for NSAID-induced Enteropathy in Arthritis Patients NCT05993247 | Jae Myung Park | Phase 2 |
| Unknown | Photobiomodulation Therapy to Reduce Pain and Inflammation in Patients With Gonarthrosis NCT05975957 | D'Or Institute for Research and Education | N/A |
| Completed | Comparing Exercise Programs for Managing Knee Osteoarthritis NCT06711341 | Uludag University | N/A |
| Active Not Recruiting | Cemented vs Cementless Persona Keel RCT NCT05630053 | Zimmer Biomet | N/A |
| Completed | Examining the Effect of Neuromuscular Exercises on Movement Control in Hip & Knee Osteoarthritis: A Randomised NCT06963892 | University of Southampton | N/A |
| Completed | The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties NCT07236073 | Ataturk University | N/A |
| Recruiting | Transcatheter Arterial Micro-Embolization (TAME) Using Nexsphere-F in Patients With Chronic Pain in Elbow or W NCT06207851 | Next Biomedical Co., Ltd. | N/A |
| Recruiting | SPECT-CT vs MRI for the Diagnosis of Osteoarthritis in the Foot and Ankle NCT05912153 | Martini Hospital Groningen | — |
| Recruiting | Investigation of the Clinical Efficacy of Low-dose Ionizing Radiation in the Treatment of Osteoarthritis NCT05887284 | University of Erlangen-Nürnberg Medical School | N/A |
| Unknown | The Living With a Long-Term Condition Study NCT06072287 | King's College London | — |
| Terminated | A 12-Week Home-Based Electrical Stimulation Program for Strength in Adults With Knee Osteoarthritis NCT05765435 | Cionic, Inc. | N/A |
| Completed | Touch on One Thumb, RSI on the Other Thumb: Which Surgery Shows Better Results NCT05849506 | Schulthess Klinik | — |
| Completed | A Randomized, Double-Blind, Controlled Trial to Assess the Efficacy of a Fortetropin Supplement in Improving S NCT06021665 | MYOS Corp | N/A |
| Active Not Recruiting | Pivotal Study to Evaluate Efficacy and Safety of SP5M002 Inj. as Compared to Synovian Inj. in Patients With Mi NCT06399042 | Shin Poong Pharmaceutical Co. Ltd. | Phase 3 |
| Withdrawn | A Randomized Controlled Trial for Partial Knee Arthroplasty NCT05037734 | Zimmer Biomet | N/A |
| Active Not Recruiting | PROs Following Low-dose Irradiation for Osteoarthritis NCT05705947 | University of North Carolina, Chapel Hill | — |
| Completed | To Investigate Effects of Amway Bundle Combination of Products on Osteoarthritis & Sarcopenia NCT05872360 | Amway (China) R&D Center | N/A |
| Unknown | Joint Self-Assessment Forms for Knee, Ankle and Shoulder NCT06343857 | University Hospital of Ferrara | — |
| Unknown | Pain Management In Knee Osteoarthritis NCT05844319 | Istanbul University | N/A |
| Completed | Precision Application of Clostridium Butyricm of Clinical Research on Osteoarthritis NCT06570408 | China Medical University Hospital | N/A |
| Unknown | Effects of Isometric Versus Isotonic Exercise in Female Patients With Osteoarthritis NCT05873088 | Superior University | N/A |
| Active Not Recruiting | Impact of Different Exercise Programs on Knee OA NCT05844124 | Shirley Ryan AbilityLab | N/A |
| Unknown | The Impact of a Seated Compact Elliptical Trainer on Individuals With Knee OA NCT05857605 | Shirley Ryan AbilityLab | N/A |
| Unknown | Efficacy of a Single Injection of CTM for Post-Operative CMC Arthritis NCT06171529 | Indiana Hand to Shoulder Center | N/A |
| Completed | Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis NCT07193368 | Feza Korkusuz MD | — |
| Completed | Telerehabilitation in Patients With Osteoarthritis NCT05719350 | Istituto Ortopedico Rizzoli | N/A |
| Recruiting | Ketorolac in Upper Extremity Tendinopathy and Arthropathy NCT05292339 | Emory University | Phase 4 |
| Completed | Hyaluronic Acid and Articular Pain NCT06814769 | University of Catanzaro | — |
| Recruiting | OSTEOMICS: Identifying Regulators of Bone Homeostasis NCT05732870 | Relation Therapeutics | — |
| Completed | Patient Observational Pain and Activity Survey (POPAS) Study Using RS-4i Sequential Stimulator With Interspers NCT05478265 | University of California, Irvine | — |
| Completed | Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis NCT06717529 | Edin Mešanović | Phase 4 |
| Unknown | Cryoneurolysis for TKA - a Pilot Study NCT05286996 | Unity Health Toronto | N/A |
| Recruiting | Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for OA NCT05147675 | The Foundation for Orthopaedics and Regenerative Medicine | Phase 1 |
| Completed | A Chronic Pain Master Protocol (CPMP): A Study of LY3857210 In Participants With Osteoarthritis Pain NCT05620563 | Eli Lilly and Company | Phase 2 |
| Recruiting | A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patient NCT06218784 | iN Therapeutics Co., Ltd. | Phase 1 |
| Completed | Mind-body Approach and Gut Microbiota in Osteoarthritis NCT05186714 | Tufts Medical Center | N/A |
| Completed | Physical Parameters in Osteoarthritis Stages NCT06015412 | Selcuk University | — |
| Suspended | Omnibond vs Dermabond NCT05173519 | Center for Innovation and Research Organization | N/A |
| Terminated | PINNACLE® DM RSA Study NCT05357664 | DePuy Orthopaedics | N/A |
| Withdrawn | Investigating RELEARN Neurofeedback as Treatment for Chronic Musculoskeletal Pain NCT05335486 | Redo-Neurosystems | Phase 2 / Phase 3 |
| Completed | Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1 NCT05813652 | McMaster University | — |
| Withdrawn | The Use of Cannabinoid Patch for Knee Osteoarthritis NCT04412837 | Northwell Health | Phase 2 |
| Completed | Comparison of a Single RTX-GRT7039 and Placebo Intra-articular Injection for Pain Associated With Osteoarthrit NCT05449132 | Grünenthal GmbH | Phase 3 |
| Completed | Open-label Trial to Check the Safety and Tolerability of RTX-GRT7039 Injections for Pain Associated With Osteo NCT05377489 | Grünenthal GmbH | Phase 3 |
| Unknown | New Method of Surgical Treatment of Patients With Osteoarthritis of the 1st Metatarsophalangeal Joint NCT05717413 | Samara State Medical University | — |
| Unknown | Thromboxane A2 and Osteoarthritis NCT05593640 | Centre Hospitalier Universitaire de Nice | — |
| Completed | Efficacy and Safety of RTX-GRT7039 in Adult Subjects With Knee Osteoarthritis NCT05248386 | Grünenthal GmbH | Phase 3 |
| Recruiting | Stem Cell Study in Osteoarthritis of the Knee and Hip Joints NCT05507099 | Grigory Karmy | Phase 2 |
| Completed | Effects of Neuromobilization, Tendon Gliding, and Robotic Glove-Assisted Exercises on Hand Osteoarthritis NCT06901024 | Hasan Kalyoncu University | N/A |
| Unknown | Evolution of the State of Health of Patients Undergoing Surgery for Osteoarticular Surgery NCT05527860 | University Hospital, Strasbourg, France | — |
| Completed | Efficacy and Safety of S (+) - Ibuprofen in Osteoarthritis Pain NCT04637529 | Apsen Farmaceutica S.A. | Phase 2 |
| Completed | Prospective Clinical Study to Evaluate the Safety and Efficacy of Intraarticular Administration of Micro-graft NCT06997991 | Azienda Ospedaliero, Universitaria Ospedali Riuniti | N/A |
| Completed | Translating Metabolic Responses to Mechanical Insult Into Early Interventions to Prevent PTOA NCT04589611 | J L Marsh | Phase 1 / Phase 2 |
| Suspended | Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis NCT05276895 | Assiut University | N/A |
| Unknown | OA Optimization Program Pilot Trial NCT05389371 | University of Calgary | Phase 1 / Phase 2 |
| Completed | Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology NCT05116163 | Brigham and Women's Hospital | N/A |
| Unknown | Pharmacist Provided Intervention (Education and Medication Review) in Osteoarthritis NCT05337709 | Monash University Malaysia | N/A |
| Completed | A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis NCT05975879 | NPO Petrovax | N/A |
| Completed | The Cherokee Study: Cherokee Health for Elderly Residents With Osteoarthritis of the Knee NCT04946344 | Wake Forest University | N/A |
| Unknown | The Clinical Effect of Pregabalin on Neuropathic Pain in Central Sensitized Patients After Total Knee Arthropl NCT05254652 | The Catholic University of Korea | N/A |
| Unknown | The Clinical Effect of Pregabalin on Neuropathic Pain in Non Central Sensitized Patients After Total Knee Arth NCT05322681 | The Catholic University of Korea | N/A |
| Unknown | Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of HYALEXO NCT05229458 | Yooyoung Pharmaceutical Co., Ltd. | — |
| Completed | Intra-articular Pulsed Radiofrequency in Chronic Knee Pain NCT06017674 | Başakşehir Çam & Sakura City Hospital | N/A |
| Not Yet Recruiting | S-11 SMR TT Hybrid Glenoid and Cementless Finned Short Stem NCT05314387 | Limacorporate S.p.a | — |
| Unknown | Volar Locking Plate Versus External Fixation for Distal Radius Fracture - a Longterm Follow up NCT05371938 | Olof Skoldenberg | N/A |
| Completed | Phone-Based Based Walk With Ease Program for Adults With Arthritis NCT05289544 | University of South Carolina | N/A |
| Recruiting | Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry NCT04536103 | Xiaojuan Li | — |
| Completed | Identification of miRNAs Associated With Gender Difference in Osteoarthritis Patients NCT04851210 | Istituto Ortopedico Rizzoli | — |
| Completed | A Study to Assess Efficacy of Supporting Properties and Safety of ARTNEO in Patients With Knee Osteoarthritis NCT06032442 | NPO Petrovax | N/A |
| Unknown | Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women NCT05889598 | Loughborough University | N/A |
| Recruiting | Sustained Acoustic Medicine for Osteoarthritis Pain NCT05254574 | ZetrOZ, Inc. | Phase 1 |
| Terminated | Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Unicondylar Knee Arthroplasty (U NCT04797897 | Smith & Nephew, Inc. | N/A |
| Active Not Recruiting | Predictive Model for 1-Year Pain and Function Outcomes After Thumb Joint Surgery in Osteoarthritic Patients NCT06740851 | Michael Oyewale | — |
| Unknown | Delivery of Enhance Fitness Trial NCT05275348 | University of Washington | N/A |
| Recruiting | Geniculate Artery Embolization for Osteoarthritis NCT04456569 | University of Minnesota | N/A |
| Enrolling By Invitation | Post Market Clinical Follow-Up Study for EVOLUTION® NitrX™ Keeled Tibia and EVOLUTION® NitrX™ CS/CR Femur With NCT04816773 | MicroPort Orthopedics Inc. | — |
| Completed | The Effect of Telerehabilitation-Based Exercise and Training on Outcome Measures in Patients With Knee Osteoar NCT05209893 | Ege University | N/A |
| Not Yet Recruiting | Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions NCT03390920 | R3 Stem Cell | N/A |
| Recruiting | Can Digitally Delivered First-line Osteoarthritis Treatment Improve Equal Access to Care NCT06148779 | Joint Academy | — |
| Withdrawn | A Comparison of Patients Receiving a Unicompartmental Knee Replacement With Robotic Assistance or With Convent NCT04992078 | Smith & Nephew Orthopaedics AG | N/A |
| Active Not Recruiting | A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in NCT05197036 | Smith & Nephew, Inc. | — |
| Completed | Platelet-rich Plasma Infiltration Versus Corticosteroid Infiltration (Prednisolone) in Treatment of Lumbar Fac NCT05105256 | CHU de Reims | N/A |
| Completed | Adapting REhabilitation Delivery for Maximum Impact at Home NCT05164575 | University of Alberta | N/A |
| Enrolling By Invitation | Quest to Analyze One Thousand Humans Meditating NCT06583395 | Tobias Moeller-Bertram | — |
| Completed | Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Osteoarthritis NCT05080660 | Eli Lilly and Company | Phase 2 |
| Withdrawn | A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instr NCT04976972 | Smith & Nephew Orthopaedics AG | N/A |
| Completed | A Clinical Trial Investigating the Effect of Salmon Bone Meal on Osteoarthritis Among Men and Women NCT05070871 | Hofseth Biocare ASA | N/A |
| Completed | The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study NCT04956393 | University of British Columbia | N/A |
| Unknown | Diphenhydramine Ointment for Knee Osteoarthritis NCT05036174 | Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology | N/A |
| Completed | Effects of Using Custom Photobiomodulation Therapy for the Treatment of Osteoarthritis of the Fingers and Rhiz NCT05041231 | Vita Care | N/A |
| Unknown | A Comparison of PRP Treatment to the IA vs. IA and EA Environments in Patients Diagnosed With Hip Osteoarthrit NCT04241354 | Regenerative Orthopedics and Sports Medicine | Phase 1 |
| Completed | The Effects of Disease Management Training and Telephone Counseling Service for Elderly Patients With Osteoart NCT04816474 | KTO Karatay University | N/A |
| Unknown | Effect of Metformin on Patients With Osteoarthritis NCT05034029 | Guangzhou First People's Hospital | N/A |
| Completed | Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion NCT04906499 | University of North Carolina, Chapel Hill | N/A |
| Completed | FTIH Study of ECC0509 in Healthy Volunteers NCT05012423 | Eccogene | Phase 1 |
| Recruiting | Oral Nutritional Optimization in Total Joint Arthroplasty NCT04210284 | NYU Langone Health | N/A |
| Active Not Recruiting | The Technology, Exercise Programming, and Activity Prescription for Enhanced Mobility (TEAM) Study NCT04544904 | Western University, Canada | N/A |
| Unknown | Multimodal Geriatric Pre-authorization Before Scheduled Orthopedic Surgery NCT05062109 | Gérond'if | N/A |
| Unknown | Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy NCT04885751 | Seoul National University Boramae Hospital | Phase 4 |
| Active Not Recruiting | Digital Osteoarthritis Care NCT04767854 | Diakonhjemmet Hospital | N/A |
| Active Not Recruiting | Persona Ti-Nidium Post-Market Clinical Follow-up NCT04817969 | Zimmer Biomet | N/A |
| Terminated | Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis NCT04864392 | Novartis Pharmaceuticals | Phase 2 |
| Unknown | A Comparative Trial of a Minimal-invasive Technique Versus Open Arthrodesis in the Treatment of Midfoot Arthri NCT04894578 | Kantonsspital Baden | N/A |
| Terminated | Comparison of Training Load With/Out Blood Flow Restriction Training in Rheumatoid Populations NCT04309227 | Louisiana State University Health Sciences Center Shreveport | N/A |
| Completed | Functionally Aligned vs Mechanical Axis Aligned Total Knee Arthroplasty NCT04748510 | Perth Hip and Knee | N/A |
| Completed | Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment With Bromelain, Trypsin and Rutoside NCT05038410 | Mucos Pharma GmbH & Co. KG | N/A |
| Recruiting | The KinematX Midcarpal Total Wrist Arthroplasty Registry NCT05719935 | Extremity Medical | — |
| Completed | Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain NCT04867057 | ZYUS Life Sciences Inc. | Phase 1 |
| Completed | Effects of ASC Secretome on Human Osteochondral Explants NCT04223622 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Completed | Auricular Vagus Nerve Stimulation in Painful and Inflammatory Erosive Hand Osteoarthritis NCT04520516 | Assistance Publique - Hôpitaux de Paris | N/A |
| Terminated | Efficacy of PRGF Supplementation After TMJ Arthrocentesis in Patients With TMJ Osteoarthritis NCT04731233 | University of Florida | Phase 4 |
| Completed | COVID-19 in Osteoarthritis Patients NCT04791462 | University Hospital, Montpellier | — |
| Suspended | Bandgrip vs Traditional Sutures TJA NCT05166642 | Center for Innovation and Research Organization | N/A |
| Terminated | Low Level Laser Therapy (LLLT) for the Treatment of Hand Osteoarthritis. NCT04692597 | David Moss | N/A |
| Withdrawn | The Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Conventional Therapy in Patients With Osteoarthr NCT04789837 | Sadat City University | Phase 1 / Phase 2 |
| Completed | Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in To NCT04730271 | DePuy Orthopaedics | N/A |
| Terminated | Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies NCT04785651 | Istituto Ortopedico Rizzoli | N/A |
| Completed | Effect of Kinesio Taping and Sham Taping in Knee Osteoarthritis NCT05320562 | Lithuanian Sports University | N/A |
| Unknown | Cam Type FAI is a Cause of Hip Pain in the Young Adult and a Precursor to OA NCT04080466 | Ottawa Hospital Research Institute | Phase 2 |
| Terminated | COVID-19 Vaccination in Rheumatic Disease Patients NCT04839315 | Mayo Clinic | EARLY_Phase 1 |
| Completed | Vacuum Therapy and Stabilization Splints Efficacious for the Management of Temporo-mandibular Joint Osteoarthr NCT06228612 | Mansoura University | N/A |
| Completed | Clinical Trial on the Articular Pain With a Cucumber Supplement in Patients Diagnosed With Arthrosis NCT04607759 | Universidad Católica San Antonio de Murcia | N/A |
| Completed | Study of OLP-1002 Injections for Reducing Moderate to Severe Pain Due to Osteoarthritis in Hip and/or Knee Joi NCT05216341 | OliPass Corporation | Phase 2 |
| Unknown | Effectiveness and Safety of Celecoxib (Celebrex 200 mg) Combined With Joins in the Treatment of Degenerative K NCT04718649 | The Catholic University of Korea | N/A |
| Completed | Innovative Device for Pain Management by Millimeter Band Radiation : Electronic-Pain Killer. NCT04590079 | University Hospital, Grenoble | N/A |
| Completed | Geniculate Artery Embolization for Treatment of Osteoarthritis NCT04379700 | NYU Langone Health | N/A |
| Completed | Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP) (R33) NCT04533711 | University of North Carolina, Chapel Hill | N/A |
| Active Not Recruiting | A Trial of Mechanical Axis With Soft Tissue Release Balancing vs Functional Alignment With Bony Release Balanc NCT04600583 | Stryker South Pacific | N/A |
| Completed | Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis NCT04627038 | Eli Lilly and Company | Phase 2 |
| Terminated | Adductor Canal Block NCT04513145 | OrthoCarolina Research Institute, Inc. | Phase 2 / Phase 3 |
| Completed | Effects of an Online Training Program for Physiotherapists About Weight Management for People With Osteoarthri NCT04574804 | University of Melbourne | N/A |
| Completed | Diagnostic Accuracy of Dual-energy CT NCT04585113 | Henning Bliddal | — |
| Completed | A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers NCT05496205 | iN Therapeutics Co., Ltd. | Phase 1 |
| Completed | Comparison of Functional Outcome in Patients After Hip Arthroplasty Depending on Surgical Approach NCT03850665 | Medical University of Warsaw | N/A |
| Completed | Study of Safety, Tolerability and Pharmacokinetics of LNA043 in Japanese Osteoarthritis Participants NCT04564053 | Novartis Pharmaceuticals | Phase 1 |
| Unknown | Osteoarthritis, Balance, and Fear of Falling NCT04660357 | Hacettepe University | — |
| Completed | A Trial of APPA in the Treatment of Knee Osteoarthritis NCT04657926 | AKL Research and Development | Phase 2 |
| Completed | Incorporating Wearable Technology for Enhanced Rehabilitation Monitoring After Hip and Knee Replacement NCT06157190 | PXL University College | — |
| Recruiting | Knee Osteoarthritis in the Region of Norrbotten NCT06451510 | Umeå University | — |
| Terminated | Comparative Effectiveness of Particulate Versus Nonparticulate Steroid Injections for Musculoskeletal Conditio NCT04278833 | Stanford University | Phase 4 |
| Recruiting | The Combined Use of PRP with Lipoaspirate And/or Bone Marrow Aspirate in Osteoarthritis NCT03984461 | Dr. Grant M. Pagdin | Phase 2 |
| Unknown | Reliability of Measuring Walking-related Performance Fatigability Using Six Minute Walk Test in Persons With K NCT04530266 | Foundation University Islamabad | N/A |
| Completed | A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809 NCT05214677 | Daewon Pharmaceutical Co., Ltd. | Phase 1 |
| Completed | A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809-T2 NCT05214690 | Daewon Pharmaceutical Co., Ltd. | Phase 1 |
| Unknown | Visual Feedback Non-weight Bearing Exercise on the Elderly With Knee Osteoarthritis. NCT04919486 | Taipei Medical University | N/A |
| Completed | COMPARATIVE STUDY OF THE EFFICACY OF HYALURONIC ACID, DRY NEEDLING AND COMBINED TREATMENT IN PATELLAR OSTEOART NCT03743818 | Universidad Católica de Ávila | N/A |
| Completed | Chronic Pain Master Protocol (CPMP): A Study of LY3016859 in Participants With Osteoarthritis NCT04456686 | Eli Lilly and Company | Phase 2 |
| Completed | Reducing Obesity and Cartilage Compression in Knees NCT04730557 | Duke University | N/A |
| Completed | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Multiple Subcutaneo NCT04677933 | OliPass Australia Pty Ltd | Phase 1 |
| Completed | Hydrolyzed Collagen in the Reduction of Osteoarticular Pain and Functional Limitation NCT05149053 | Francisco Jose Rodriguez Velasco | N/A |
| Completed | Intra-articular Polyacrylamide Hydrogel in Gonarthrosis NCT06429319 | Research Centre BIOFORM | N/A |
| Completed | A Study to Assess Efficacy and Safety of the Ketoprofen vs Diclofenac NCT04421911 | Handok Inc. | Phase 3 |
| Completed | Resiliency in Total Joint Arthroplasty NCT04357262 | University of Utah | N/A |
| Unknown | Cemented vs Cementless in Bilateral TKA NCT04496102 | Thammasat University | N/A |
| Completed | Development and Evaluation of a Web Based Decision Aid for Patients With Hip Osteoarthritis NCT04241978 | Servicio Canario de Salud | N/A |
| Terminated | Anterior Advantage With KINCISE NCT04191733 | DePuy Orthopaedics | N/A |
| Recruiting | Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis NCT04238143 | Healeon Medical Inc | N/A |
| Recruiting | A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes NCT06687109 | Spokane Joint Replacement Center | — |
| Withdrawn | Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis NCT04115020 | Brigham and Women's Hospital | Phase 2 |
| Completed | Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and NCT04654871 | Foundation University Islamabad | N/A |
| Unknown | Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis NCT04207021 | KOS Care SRL - Istituto di Riabilitazione Santo Stefano | N/A |
| Completed | Effects of Dry Needling on Muscle Function in Patients With Hip Osteoarthritis NCT04195464 | Universidad de Zaragoza | N/A |
| Terminated | Pinnacle RSA Study NCT04070989 | DePuy Orthopaedics | N/A |
| Completed | Intra-articular Polyacrylamide Hydrogel in Knee Osteoarthritis NCT03897686 | Research Centre BIOFORM | N/A |
| Unknown | Functional Exercise Response on osteoArthritis Relaxation Imaging NCT03657303 | Cambridge University Hospitals NHS Foundation Trust | — |
| Withdrawn | The Effects of Stromal Vascular Fraction and Mesenchymal Stem Cells as Intra-articular Injection in Knee Joint NCT03164083 | SCARM Institute, Tabriz, Iran | Phase 2 |
| Unknown | PARQUE 70+ Studying Sleep Disorder NCT04059419 | University of Sao Paulo General Hospital | N/A |
| Completed | Osteoarthritis in Terms of ICF Components NCT04956510 | Pamukkale University | — |
| Withdrawn | Radial Medical - GAPS NCT04163913 | NYU Langone Health | N/A |
| Completed | Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain NCT04009837 | University of Delaware | N/A |
| Withdrawn | TKR With and Without the Use of Intra-operative Sensing NCT04251442 | Hospital for Special Surgery, New York | N/A |
| Completed | Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthrop NCT04075526 | NYU Langone Health | Phase 1 |
| Completed | Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients NCT04351100 | Chulalongkorn University | — |
| Completed | Understanding Cognition, Oxytocin & Pain in Elders NCT03878589 | University of Florida | Phase 2 / Phase 3 |
| Unknown | Effect of a Patient-Centered Mobile App Self-Management Program for Osteoarthritis NCT05634304 | Chang Gung Memorial Hospital | N/A |
| Unknown | Investigation of Oxidative Markers and Antioxidant Defense in Female Patients With Osteoarthritis NCT04206462 | Iuliu Hatieganu University of Medicine and Pharmacy | — |
| Withdrawn | Long Term Sidus PMCF NCT04063943 | Zimmer Biomet | N/A |
| Completed | Effects of Anthriscus Sylvestris Leaves on Mild Knee Osteoarthritis NCT06535204 | Pusan National University Hospital | N/A |
| Unknown | ORCA Study: Osteoarthritis and Risks Associated With the Consumption of NSAIDs NCT04099459 | Scandinavia Pharma | — |
| Unknown | Low Intensity Pulsed Ultrasound Versus High Intensity Continuous Ultrasound Therapy in Knee Osteoarthritis NCT04406337 | Ministry of Health and Sports, Myanmar | N/A |
| Completed | Study Title: Food Rx NCT03937934 | Mayo Clinic | N/A |
| Completed | Colchicine for the Treatment of Osteoarthritis of the Knee NCT03913442 | NYU Langone Health | Phase 4 |
| Unknown | Crucumin Effects on the Immune System in Osteoarthritis Patients NCT03715140 | Mashhad University of Medical Sciences | Phase 3 |
| Completed | Broccoli In Osteoarthritis NCT03878368 | University of East Anglia | N/A |
| Completed | MRgFUS in the Treatment of Hand and Hip Osteoarthritic Pain NCT03467165 | Istituto Ortopedico Rizzoli | N/A |
| Terminated | Chronic Pain, Couples, & Physical Activity NCT04077164 | Illinois Institute of Technology | — |
| Unknown | Adipose-derived Mesenchymal Stem Cells in Osteoarthritis NCT03869229 | Medical University of Warsaw | Phase 1 / Phase 2 |
| Completed | Application of Injectable Platelet-Rich Fibrin for the Treatment of Temporomandibular Joint Osteoarthritis NCT04810923 | Ege University | N/A |
| Unknown | Psychosocial Factors a Prognostic Study of Pain in Patients With CMC Osteoarthritis NCT03821298 | Gannon University | N/A |
| Completed | Efficacy and Safety of ATB-346 Versus Placebo in Osteoarthritis Patients NCT03978208 | Antibe Therapeutics Inc. | Phase 2 |
| Completed | Enthesitis in Patients With Knee Osteoarthritis NCT03897829 | Al-Azhar University | — |
| Completed | Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) NCT03818737 | Emory University | Phase 3 |
| Completed | Physical Activity Pathway for Patients With Osteoarthritis in Primary Care (OA-PCP) NCT03780400 | University of North Carolina, Chapel Hill | N/A |
| Completed | Audio-visual Stimulation: Sleep Dose Response NCT03569865 | University of Washington | N/A |
| Completed | Lumbar Plexus Block Versus Quadratus Lumborum Block for Primary Anterior Total Hip Arthroplasty NCT03409900 | Wake Forest University Health Sciences | N/A |