Trials / Completed

CompletedNCT06717529

Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis

Status: Completed
Phase: Phase 4
Study type: Interventional
Enrollment: 65 (actual)

Sponsor: Edin Mešanović · Academic / Other
Sex: All
Age: 18 Years
Healthy volunteers: Not accepted

Summary

The aim of this study is to compare functional and clinical outcomes of intraarticular injections of hyaluronic acid and steroids in patients with bilateral knee osteoarthritis. We will compare clinical and functional outcomes for each knee separately after week 6, month 3, month 6, and one year after the intervention.

Detailed description

We will include patients with bilateral knee osteoarthritis (Kellgren Lawrence grades 2 and 3). On initial examination, we will measure active and passive range of flexion and extension, presence of swelling, joint effusion, VAS score for each knee separately, and WOMAC score for every knee separately. We will randomly apply hyaluronic acid injection in one knee and steroid injection in the other knee. We will repeat the same examination after week 6, month 3, month 6, and one year after the procedure. The main aim is to check whether there is a significant clinical or functional difference between two groups.

Conditions

Interventions

Type	Name	Description
OTHER	Sodium hyaluronate (hyaluronic acid)	The patient will receive one 3mL Sodium Hyaluronate injection containing 75 mg of active substance in one knee joint.
DRUG	Methylprednisolone Acetate Injection	The patient will receive 2mL of methylprednisolone acetate solution containing 80 mg of the medicine in other knee joint.

Timeline

Start date: 2023-01-01
Primary completion: 2023-11-15
Completion: 2024-09-30
First posted: 2024-12-05
Last updated: 2024-12-05

Locations

1 site across 1 country: Bosnia and Herzegovina

Source: ClinicalTrials.gov record NCT06717529. Inclusion in this directory is not an endorsement.