| Recruiting | Efficacy of Aerobic Exercise Versus Therapeutic Exercises on Exercise-induced Hypoalgesia in Knee Osteoarthrit NCT07302204 | University of Nove de Julho | N/A |
| Recruiting | Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Kne NCT07338266 | Avidence Therapeutics | Phase 1 |
| Completed | Pilot Study to Identify and Validate Digital Biomarkers in Osteoarthritis of the Knee NCT07031518 | Centre Hospitalier Universitaire de Liege | N/A |
| Enrolling By Invitation | Shengyu Decoction and Lijin Manipulation for Knee OA: 3D Gait Analysis NCT06451783 | Xuhui Central Hospital, Shanghai | EARLY_Phase 1 |
| Recruiting | RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques NCT06389435 | Danderyd Hospital | N/A |
| Completed | Analgesic Effects of a Treatment With Cannabis Sativa Extract in Patients With Knee Osteoarthritis - CANOA (Ca NCT06588972 | Federal University of Latin American Integration | Phase 2 |
| Withdrawn | Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis NCT05742763 | QC Kinetix LLC | Phase 1 / Phase 2 |
| Recruiting | A Phase III Study of CLS2901C in Patients With Osteoarthritis of the Knee NCT06549686 | CellSeed Inc. | Phase 3 |
| Unknown | Different Modalities of Aquatic Physiotherapy in Patients With Knee Osteoarthrosis NCT05610696 | Federal University of Health Science of Porto Alegre | N/A |
| Completed | Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis NCT07193368 | Feza Korkusuz MD | — |
| Completed | Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis NCT06717529 | Edin Mešanović | Phase 4 |
| Recruiting | Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection NCT05985785 | Rush University Medical Center | N/A |
| Terminated | ATTUNE Cementless FB Tibial Base Clinical Study NCT04630262 | DePuy Orthopaedics | N/A |
| Active Not Recruiting | A Pragmatic Trial to Determine the Benefit of Behaviorally Enhanced Exercise Incentives and Corticosteroid Inj NCT05035810 | VA Office of Research and Development | Phase 3 |
| Recruiting | Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee NCT04992624 | Steven E Harte, PhD | Phase 2 |
| Unknown | Identification of Sarcopenia in Knee Osteoarthritis With Ultrasonography and Evaluation of Muscle Architecture NCT05019820 | Sema Dağcı | Phase 4 |
| Completed | Postmarketing Multicenter Study of Intra-Articular DIART ONE / EASYGO ONE for Knee Osteoarthritis NCT06927934 | Yuria-Pharm | — |
| Terminated | 3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis NCT04931667 | Biosplice Therapeutics, Inc. | Phase 3 |
| Unknown | Exploratory Study on Safety of PEEK Knee Prosthesis NCT04927104 | RenJi Hospital | N/A |
| Completed | Irritation and Sensitization Study of HP-5000 Topical System NCT04882319 | Noven Pharmaceuticals, Inc. | Phase 1 |
| Unknown | LOW LOAD RESISTANCE BLOOD FLOW RESTRICTION TRAINING VERSUS NEUROMUSCULAR TRAINING IN KNEE OSTEOARTHRITIS NCT04600661 | Mai Mohamed Abdelkader Abdallah | N/A |
| Completed | Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain NCT04123561 | Taiwan Liposome Company | Phase 3 |
| Completed | Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain NCT04145011 | Avanos Medical | N/A |
| Completed | A Pragmatic Trial To Determine the Benefit of Exercise Incentives and Corticosteroid Injections in Osteoarthri NCT03835910 | VA Office of Research and Development | N/A |
| Terminated | A Study to Examine the Efficacy and Safety of REGN5069 in Patients With Pain Due to Osteoarthritis of the Knee NCT03956550 | Regeneron Pharmaceuticals | Phase 2 |
| Completed | A Phase 2, Open Label, Pharmacokinetic (PK) Study of TLC599 in Subjects With Osteoarthritis of the Knee NCT03754049 | Taiwan Liposome Company | Phase 2 |
| Withdrawn | A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee NCT00837291 | Can-Fite BioPharma | Phase 2 |
| Unknown | Clinical Study of Umbilical Cord Mesenchymal Stem Cells (UC-MSC) for Treatment of Knee Osteoarthritis NCT03166865 | Liaocheng People's Hospital | Phase 1 / Phase 2 |
| Completed | Cooled Radiofrequency vs. Hyaluronic Acid to Manage Knee Pain NCT03381248 | Avanos Medical | N/A |
| Completed | A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis NCT03277066 | Noven Pharmaceuticals, Inc. | Phase 2 |
| Unknown | 3D Printing Guides in Total Knee Arthroplasty NCT04206202 | Southwest Hospital, China | N/A |
| Completed | Polycan in Combination With Glucosamine for Treatment of Knee Osteoarthritis NCT03717714 | Vietstar Biomedical Research | N/A |
| Completed | Phase IIa, Randomized, Double Blinded, Placebo Controlled, Dose Finding Study for TLC599 in OA Patients NCT03005873 | Taiwan Liposome Company | Phase 2 |
| Active Not Recruiting | Multicentre GMK UNI Anatomical Cementless Study - FR NCT06715917 | Medacta International SA | — |
| Completed | Study to Assess the Safety of Repeat Administration of FX006 Administered to Patients With Osteoarthritis of t NCT03046446 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Unknown | Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management NCT02925442 | Lyman Medical Research Foundation, Inc. | N/A |
| Unknown | Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total NCT02760459 | Chiang Mai University | Phase 4 |
| Completed | KineSpring® System Patient Preference Study NCT02934672 | Moximed | — |
| Completed | Evaluation of Amniotic Fluid Product in Knee Osteoarthritis NCT02768155 | MiMedx Group, Inc. | N/A |
| Completed | Study to Assess the Effects of FX006 on Blood Glucose in Patients With OA of the Knee and Type 2 Diabetes NCT02762370 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Completed | A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain NCT02712957 | Neomed Institute | Phase 2 |
| Completed | A Study to Assess the Analgesic Efficacy of ASP7962 in Patients With Pain Due to Osteoarthritis of the Knee NCT02611466 | Astellas Pharma Europe B.V. | Phase 2 |
| Completed | A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in A NCT02604381 | KGK Science Inc. | Phase 2 |
| Completed | Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the K NCT02637323 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Completed | A Study to Evaluate the Efficacy & Safety of an Intra-Articular Ampion Injection for Pain of Osteoarthritis of NCT02556710 | Ampio Pharmaceuticals. Inc. | Phase 3 |
| Unknown | Outcomes of Injections in Patients Waiting for Total Knee Replacement NCT03090698 | Universidade Federal Fluminense | Phase 4 |
| Completed | Single-Dose Administration Trial of TLC599 in Osteoarthritis of the Knee NCT02803307 | Taiwan Liposome Company | Phase 1 / Phase 2 |
| Unknown | PRP Treatment of Osteoarthritic Knee With a New Autologous Blood Product (CytoRich) NCT03543800 | Antnor | N/A |
| Unknown | A Prospective Radiostereometric Analysis (RSA) and Clinical Evaluation of the Triathlon Tritanium Total Knee R NCT02373761 | Scott Sporer | — |
| Completed | Repeat Injection of Cingal® for Osteoarthritis of the Knee NCT02381652 | Anika Therapeutics, Inc. | Phase 3 |
| Completed | Study of FX006 for the Treatment of Pain in Patients With Osteoarthritis of the Knee NCT02357459 | Pacira Pharmaceuticals, Inc | Phase 3 |
| Completed | Nerve Ablation by Cooled Radiofrequency Compared to Corticosteroid Injection for Management of Knee Pain NCT02343003 | Halyard Health | N/A |
| Completed | An Extension Study of Duloxetine in Osteoarthritis and Knee Pain (Extension of F1J-JE-HMGX, NCT02248480) NCT02335346 | Eli Lilly and Company | Phase 3 |
| Terminated | Virtual Reality for Osteoarthritis Knee Pain Pilot NCT01899508 | Duke University | N/A |
| Unknown | Knee Osteoarthritis Risk in Retired Professional Footballers NCT02098044 | University of Nottingham | — |
| Completed | A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan NCT02248480 | Eli Lilly and Company | Phase 3 |
| Completed | A Multiple Injection Study Evaluating Safety and Efficacy of Ampion in Osteoarthritis NCT02242435 | Ampio Pharmaceuticals. Inc. | Phase 3 |
| Withdrawn | Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis NCT02237846 | Translational Biosciences | Phase 1 / Phase 2 |
| Completed | A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthr NCT02184156 | Ampio Pharmaceuticals. Inc. | Phase 1 / Phase 2 |
| Completed | A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Prim NCT02068599 | Teva Branded Pharmaceutical Products R&D, Inc. | Phase 2 |
| Completed | Effect of Phototherapy Incorporated Into an Exercise Program on Osteoarthritis of the Knee NCT02102347 | University of Nove de Julho | N/A |
| Completed | Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee NCT02116972 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Completed | ADSC Injections for Pain Management of Osteoarthritis in the Human Knee Joint NCT02357485 | Fodor, Peter B, M.D. | Phase 1 |
| Completed | Cardiovascular And Metabolic Risk After Arthroplasty NCT06211465 | University of Tartu | — |
| Completed | To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients of the Knee NCT02049606 | PMG Pharm Co., Ltd | Phase 4 |
| Completed | A Study to Evaluate the Efficacy and Safety of X0002 Spray in Subjects With Osteoarthritis NCT02067611 | Lina Xu | Phase 2 |
| Terminated | Prospective Functional Outcome Study of the Knee NCT02079493 | Tufts Medical Center | — |
| Completed | Cabbage Leaf Wraps in Osteoarthritis of the Knee NCT02027792 | Universität Duisburg-Essen | N/A |
| Completed | A Randomized, Controlled Study to Evaluate Efficacy and Safety of Intra-articular Ampion for Osteoarthritis Pa NCT02024529 | Ampio Pharmaceuticals. Inc. | Phase 3 |
| Completed | Hydros and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis NCT02022930 | Carbylan Therapeutics, Inc. | Phase 3 |
| Withdrawn | Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis NCT02003131 | Translational Biosciences | Phase 1 / Phase 2 |
| Completed | Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis NCT01112722 | Apimeds, Inc. | Phase 3 |
| Completed | Study to Characterize the Local Duration of Exposure From FX006 in Patients With Osteoarthritis of the Knee NCT02003365 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Completed | Effectiveness of Osteopathy in the Preoperative Treatment of Postoperative Pain in Patients Undergoing Total K NCT01989117 | Hospital Ambroise Paré Paris | — |
| Terminated | Total Knee Arthroplasty Functional Outcomes Study Research Design NCT02228538 | Restor3D | — |
| Completed | Patient Specific Instrumentation in TKR NCT02096393 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study NCT01849445 | University of Edinburgh | N/A |
| Terminated | Nerve Burial for Preventing Neuralgia After Total Knee Arthroplasty NCT02885467 | Medstar Health Research Institute | N/A |
| Completed | Triathlon PKR Study in Japan NCT02552095 | Stryker Japan K.K. | N/A |
| Completed | Effect of Bioskin Ten-7 vs. Standard Treatment on Patient Reported Outcomes and Cytokine. NCT02295020 | Cropper Medical | N/A |
| Completed | EMBARK Follow-up Project NCT02195674 | Duke University | — |
| Completed | An Efficacy and Safety Study of Two Doses of Intra-Articular Ampion Injection for Pain of Osteoarthritis of th NCT01839331 | Ampio Pharmaceuticals. Inc. | Phase 2 |
| Completed | Sleep, Pain and Inflammatory Processes in Older Adults With Osteoarthritis NCT01683799 | University of Rochester | N/A |
| Terminated | A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System NCT01820650 | Restor3D | — |
| Completed | Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee NCT01768975 | Olatec Therapeutics LLC | Phase 2 |
| Completed | Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee NCT01756937 | Chong Kun Dang Pharmaceutical | Phase 4 |
| Unknown | Flex Intramedullary Rod Study NCT02543489 | Stryker Japan K.K. | N/A |
| Completed | The Study to Evaluate Efficacy and Safety of Imotun Capsule in Osteoarthritis of the Knee NCT01743287 | Chong Kun Dang Pharmaceutical | Phase 4 |
| Completed | To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients NCT01768468 | PMG Pharm Co., Ltd | Phase 4 |
| Completed | A Prospective Study Evaluating the Treatment of Knee Osteoarthritis With the Cryo-Touch III Device NCT01704157 | Pacira Pharmaceuticals, Inc | N/A |
| Completed | Pharmacokinetic and Pharmacodynamic Study of FX006 in Patients With Osteoarthritis of the Knee NCT01487200 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Completed | Study of FX006 in Patients With Osteoarthritis of the Knee NCT01487161 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Completed | A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee NCT01619839 | Nektar Therapeutics | Phase 2 |
| Completed | Hydroxychloroquine/Atorvastatin in the Treatment of Osteoarthritis (OA) of the Knee NCT01645176 | Stanford University | Phase 2 |
| Completed | Assays for and Reversal of New Anticoagulants NCT01795781 | R.P.Herrmann | — |
| Terminated | Safety, Tolerability, and Efficacy of IA Verapamil in the Treatment of Joint Pain in Subjects With Osteoarthri NCT01645709 | Calosyn Pharma, Inc. | Phase 1 / Phase 2 |
| Completed | A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects Wi NCT01554579 | Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 2 |
| Suspended | Serum and Synovium Protease Inhibitor Levels in Primary and Secondary Osteoarthritic Joints NCT01613833 | Scuderi, Gaetano J., M.D. | — |
| Completed | Safety and Efficacy of Etoricoxib 30 mg Versus Celecoxib 200 mg in Korean Participants With Osteoarthritis NCT01554163 | Organon and Co | Phase 3 |
| Completed | Trial to See if Topical Pennsaid for Knee Pain Affects Coagulation Values in Patients Who Are Also Taking Anti NCT01511939 | Nathan Wei, MD, FACP, FACR: | Phase 3 |
| Completed | Structured Non-operative Treatment of Knee Osteoarthritis NCT01535001 | Northern Orthopaedic Division, Denmark | N/A |
| Withdrawn | Clinical and Stereoradiological Comparison of the Results After Primary Cemented Total Knee Arthroplasty Inser NCT01488175 | Hvidovre University Hospital | Phase 4 |
| Completed | Investigation of Specific Protein/Markers in Patients With Osteoarthritis of the Knee Having a Total Knee Repl NCT01611441 | AstraZeneca | — |
| Completed | Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis NCT01510535 | LG Life Sciences | Phase 3 |
| Completed | Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee NCT01430559 | Pfizer | N/A |
| Completed | A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthr NCT01444365 | AbbVie (prior sponsor, Abbott) | Phase 2 |
| Completed | Cross-over Study of the Efficacy and Safety of SierraSil Joint Formula 14 in Osteoarthritis of the Knee NCT02156440 | KGK Science Inc. | Phase 2 |
| Unknown | Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis NCT01270412 | Meir Medical Center | Phase 2 / Phase 3 |
| Completed | Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement NCT01410409 | Northern Orthopaedic Division, Denmark | N/A |
| Unknown | Long-Term Multicenter Evaluation of the E1® Tibial Bearing NCT01374230 | Massachusetts General Hospital | N/A |
| Completed | Can Computer-based Telephone Counseling Improve Long-term Adherence to Strength Training in Elders With Knee O NCT01394874 | Boston University Charles River Campus | N/A |
| Completed | Efficacy of Spearmint Tea in Relieving Osteoarthritis of the Knee NCT01380015 | University of Guelph | Phase 4 |
| Completed | A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee NCT01366014 | Pfizer | Phase 2 |
| Completed | Assessment of GRT6005 in Painful Osteoarthritis of the Knee NCT01357837 | Tris Pharma, Inc. | Phase 2 |
| Completed | The Use of Fibrin Sealant to Reduce Bleeding After Total Knee Replacement NCT01816282 | University of Milan | N/A |
| Terminated | Axial Alignment in Patients Operated Using the Visionaire Patient Matched Cutting Blocks NCT01224522 | Smith & Nephew Orthopaedics AG | Phase 3 |
| Completed | Measures of Pain Relevant to Knee Osteoarthritis NCT01310257 | University of Nottingham | — |
| Completed | Efficacy and Safety of 3 Different Dosage Regimens of Hyaluronic Acid in Patients With Knee Osteoarthritis (OA NCT01290497 | Tedec-Meiji Farma, S.A. | Phase 4 |
| Completed | A Study of ABT-652 in Adults With Osteoarthritis Pain of the Knee NCT01207115 | AbbVie (prior sponsor, Abbott) | Phase 2 |
| Completed | Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis NCT01119898 | Mallinckrodt | Phase 2 |
| Unknown | Prophecy Guide Outcomes in Total Knee Replacement Surgery NCT01163708 | Global Orthopaedic Technology | Phase 4 |
| Completed | Efficacy and Safety Study of Glucosamine/Chondroitin Sulfate to Patients Treatment With Osteoarthrosis of the NCT00955552 | Eurofarma Laboratorios S.A. | Phase 3 |
| Completed | Double-Blind, Randomized, Single Dose Escalation Safety Study of Intraarticular Bone Morphogenic Protein (38A NCT01133613 | Stryker Biotech | Phase 1 |
| Completed | Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee NCT01111045 | Stryker Biotech | Phase 2 |
| Completed | VISIONAIRE™ Value Study NCT01107769 | Smith & Nephew, Inc. | — |
| Completed | Hydros Joint Therapy and Hydros-TA Joint Therapy for Pain Associated With Knee Osteoarthritis (OA) NCT01134406 | Carbylan Therapeutics, Inc. | Phase 2 |
| Completed | A Randomized Prospective Trial of Total Knee Arthroplasty Options Comparing Standard Knee Cutting Guides and M NCT01072019 | Washington University School of Medicine | N/A |
| Completed | Teriparatide for Improved Knee Prosthesis Fixation NCT01063504 | University Hospital, Linkoeping | Phase 2 |
| Completed | Efficacy Study of an Unloading Brace for Knee Osteoarthritis NCT02150057 | Andrews Research & Education Foundation | N/A |
| Completed | Active Drug Comparative, Multi-center, phase3 Clinical Study to Evaluate the Efficacy and Safety of PG201 in O NCT01576419 | PMG Pharm Co., Ltd | Phase 3 |
| Unknown | Development of Knee Osteoarthritis After Arthroscopic Partial Resection of Degenerative Meniscus Tear NCT01052233 | Tampere University | Phase 4 |
| Completed | Cupping in Osteoarthritis of the Knee NCT01057043 | Charite University, Berlin, Germany | N/A |
| Completed | Efficacy and Safety Study Evaluating ADL5859 and ADL5747 in Participants With Pain Due to Osteoarthritis of th NCT00979953 | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 2 |
| Completed | Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation NCT00949754 | Apimeds, Inc. | Phase 2 |
| Completed | Investigation of 1.2% Sodium Hyaluronate for Treatment of Painful Chronic Osteoarthritis of the Knee NCT00988091 | Ferring Pharmaceuticals | Phase 3 |
| Completed | A Comparative Study of Knee Systems NCT01331278 | Foundation for Southwest Orthopedic Research | Phase 4 |
| Completed | Exploring Massage Benefits for Arthritis of the Knee NCT00970008 | University of Medicine and Dentistry of New Jersey | Phase 2 |
| Terminated | Intraarticular Ozone Therapy for Pain Control in Osteoarthritis of the Knee NCT00832312 | Ben-Gurion University of the Negev | Phase 2 |
| Completed | A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee NCT00944892 | Regeneron Pharmaceuticals | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety of Prednisolone and Chloroquine Add on Therapy in Osteoarthritis of the Knee NCT00805519 | Ardabil University of Medical Sciences | Phase 4 |
| Completed | Study of Safety and Efficacy of Diractin® for the Treatment of Osteoarthritis (OA) of the Knee NCT00722852 | IDEA AG | Phase 3 |
| Completed | Safety and Efficacy of Two Dosages of Diractin® in Osteoarthritis (OA) NCT00716547 | IDEA AG | Phase 3 |
| Completed | Comparative Study of Olive Oil With Piroxicam Gel in Osteoarthritis of the Knee NCT00670475 | Ardabil University of Medical Sciences | Phase 2 |
| Completed | Preparation Rich in Growth Factors (PRGF) Treatment for Osteoarthritis of the Knee NCT00728611 | Meir Medical Center | Phase 2 / Phase 3 |
| Completed | Total Knee Replacement Study Using Standard Cutting Guide vs Otismed MRI Generated Cutting Guide NCT00837772 | Phoenix VA Health Care System | N/A |
| Completed | Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty NCT00562627 | Asker & Baerum Hospital | Phase 4 |
| Completed | HKT-500 in Adult Patients With Osteoarthritis (OA) Knee Pain NCT00792727 | Hisamitsu Pharmaceutical Co., Inc. | Phase 3 |
| Completed | Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee NCT00531427 | Purdue Pharma LP | Phase 3 |
| Completed | Safety and Tolerability of 4975 in the Treatment of Moderate to Severe Knee Pain Due to Osteoarthritis (OA) NCT00667654 | Centrexion Therapeutics | Phase 2 |
| Completed | Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab NCT01144143 | Herbert Lindsley, MD | Phase 4 |
| Completed | Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain NCT00484120 | Pharmos | Phase 2 |
| Completed | Dose Escalation Study Of Chinese Herbs In Osteoarthritis Of The Knee NCT00755326 | University of Maryland, Baltimore | Phase 2 |
| Completed | A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects W NCT00456157 | Stryker Biotech | Phase 1 |
| Completed | Gel-200 Extension and Open-Label Study in Osteoarthritis of the Knee NCT00450112 | Seikagaku Corporation | Phase 3 |
| Unknown | The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a The NCT00422643 | Assaf-Harofeh Medical Center | Phase 4 |
| Completed | Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee NCT00589979 | Endo Pharmaceuticals | Phase 2 |
| Withdrawn | Efficacy and Safety Study of PG201 Tablet in Patients With Osteoarthritis NCT01122485 | Helixmith Co., Ltd. | Phase 2 |
| Completed | Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis NCT00426621 | Novartis | Phase 3 |
| Completed | A Gender-Specific Posterior Cruciate-Substituting High-Flexion Knee Prosthesis Does Not Improve Fit and Functi NCT00917774 | Ewha Womans University | Phase 4 |
| Completed | Gel-200 Versus Placebo in Osteoarthritis of the Knee NCT00449696 | Seikagaku Corporation | Phase 3 |
| Completed | Computer Aided Gap Balancing Improves Sagittal Stability and Outcomes for Cruciate-Retaining Total Knee Arthro NCT00865865 | Singapore General Hospital | N/A |
| Completed | Prospective Randomized Trial of Navigated and Conventional TKA NCT01022099 | Technische Universität Dresden | N/A |
| Completed | Effects of Aquamin F on NSAID Dose Reduction in Osteoarthritis of the Knee NCT00755482 | Marigot Ltd. | Phase 1 / Phase 2 |
| Completed | Effects of Aquamin F on Osteoarthritis of the Knee NCT00452101 | Marigot Ltd. | Phase 1 / Phase 2 |
| Unknown | Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis NCT00833157 | Bispebjerg Hospital | Phase 1 |
| Unknown | Efficacy of Celecoxib 200mg in Relieving Pain and Walking Dysfunction in Osteoarthritis of the Knee NCT00597415 | University Hospitals Cleveland Medical Center | Phase 2 |
| Terminated | MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty NCT00853398 | Smith & Nephew Orthopaedics AG | Phase 4 |
| Terminated | Lidocaine Patch Versus Celecoxib in Pain From Osteoarthritis of the Knee NCT00904605 | Endo Pharmaceuticals | Phase 4 |
| Completed | Acupuncture in Osteoarthritis of the Knee NCT00325663 | Heidelberg University | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety of Repeated Intraarticular Injections of Hyaluronic Acid in Patients With OA of the Knee NCT00669032 | Tedec-Meiji Farma, S.A. | N/A |
| Completed | Evaluating the Safety and Efficacy Civamide in Osteoarthritis (OA) of the Knee(s) NCT00995306 | Winston Laboratories | Phase 3 |
| Completed | A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of NCT00568295 | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 3 |
| Unknown | Autograft Versus Calcium Phosphate Macroporous Bioceramics as Bone Substitute for Tibial Valgus Osteotomy NCT00200603 | Nantes University Hospital | N/A |
| Completed | Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee NCT00562822 | University of Western Ontario, Canada | Phase 3 |
| Withdrawn | The Effectiveness of Antibiotic Cement (ABC) Compared to Regular Cement in Reducing the Rate of Infection Foll NCT01079559 | University of Western Ontario, Canada | Phase 3 |