NCT00562627

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: Asker & Baerum Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge. The aim of this study is to: 1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty. 2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Detailed description

Total knee arthroplasty (TKA) is increasingly common in the treatment of knee osteoarthritis. TKA is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge. Continuous epidural analgesia is often used for controlling pain after TKA. Recent studies describe a new method for pain control after total knee arthroplasty which consists of local infiltration with local anesthetics and adrenaline. This infiltrations can be combined with ketorolac and/or morphine. The aim of this study is to: 1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty. 2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Conditions

• Osteoarthritis of the Knee

Interventions

Type	Name	Description
DRUG	ropivacaine	intraoperative and 1. postoperative day
DRUG	adrenaline	intraoperative LIA (IV and IA) and continuous EDA
DRUG	ketorolac	intraoperative and 1. postoperative day
DRUG	morphine	intraoperative
DRUG	fentanyl	continuous postoperatively
DRUG	bupivacaine	continuous postoperatively

Timeline

• Start date: 2007-11-01
• Primary completion: 2009-06-01
• Completion: 2009-07-01
• First posted: 2007-11-22
• Last updated: 2011-08-08
• Results posted: 2011-08-08

Locations

1 site across 1 country: Norway