| Withdrawn | MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function Hepatic Encephalopathy | Phase 3 | 2021-11-01 |
| Completed | Impact of Acthar on Everyday Life of Participants With Severe Keratitis Keratitis | Phase 4 | 2019-11-13 |
| Completed | MNK6106 for Liver Disease (Hepatic Cirrhosis) That in the Past Has Affected the Brain (Hepatic Encephalopathy) Hepatic Cirrhosis, Hepatic Encephalopathy (HE) | Phase 2 | 2018-12-01 |
| Terminated | Safety and Effectiveness of Acthar Gel for Inflammation of the Eye's Uvea (Middle Layer) Uveitis, Posterior, Uveitis, Intermediate, Panuveitis | Phase 4 | 2018-10-05 |
| Completed | Acthar Gel in Participants With Pulmonary Sarcoidosis Sarcoidosis, Pulmonary | Phase 4 | 2018-02-21 |
| Terminated | Registry to Evaluate INOmax in Newborn Babies With Pulmonary Hypertension Pulmonary Hypertension of Newborn | — | 2017-07-27 |
| Terminated | Study of Acthar® Gel (Acthar) for Amyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis | Phase 2 / Phase 3 | 2017-06-22 |
| Terminated | Open-Label Safety and PK Study of ER Hydromorphone Tablets in Opioid-Tolerant Pediatric Chronic Pain Patients Chronic Pain | Phase 3 | 2017-03-11 |
| Completed | Acthar Gel for Active Systemic Lupus Erythematosus (SLE) Lupus Erythematosus, Systemic | Phase 4 | 2016-12-16 |
| Completed | Safety and Effectiveness of Acthar Gel in Participants With Rheumatoid Arthritis Arthritis, Rheumatoid | Phase 4 | 2016-11-07 |
| Completed | Single-Dose PK Study of an Oxycodone/Acetaminophen Solution in Healthy Subjects Healthy Volunteers | Phase 1 | 2016-08-01 |
| Completed | Study To Confirm Efficacy and Safety of Terlipressin in Hepatorenal Syndrome (HRS) Type 1 Hepatorenal Syndrome | Phase 3 | 2016-07-13 |
| Terminated | Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Acute Pain, Postoperative | Phase 4 | 2016-04-27 |
| Completed | Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen Pain | Phase 4 | 2016-02-01 |
| Withdrawn | Pharmacokinetics and Safety of MNK-155 in Postsurgical Adolescent Subjects With Moderate to Severe Acute Pain Acute Pain | Phase 1 | 2016-01-01 |
| Completed | Reduction in Pain Intensity Following IV or Oral Pain-relieving Products Pain | Phase 4 | 2015-12-07 |
| Completed | Observational Registry of Acthar Gel for Participants With Multiple Sclerosis Relapse Multiple Sclerosis, Relapsing-Remitting | — | 2015-11-24 |
| Terminated | Pharmacokinetics (PK) and Safety Study of XARTEMIS® XR in Postsurgical Adolescent Subjects With Moderate to Se Acute Pain | Phase 4 | 2015-11-20 |
| Terminated | Topical Raplixa for Surgical Bleeding in Children Surgical Bleeding | Phase 2 | 2014-12-04 |
| Completed | A Safety and Efficacy Study Comparing Fibrocaps and Tachosil in Hepatic Surgery Surgical Bleeding | Phase 3 | 2014-11-01 |
| Withdrawn | Safety and Efficacy Study of Acthar in Subjects With ARDS Acute Respiratory Distress Syndrome | Phase 2 | 2014-08-01 |
| Completed | Pharmacodynamic, Pharmacokinetic, and Tolerability Study of a Liquid Form of Lubiprostone in Adult Subjects Wi Chronic Idiopathic Constipation | Phase 3 | 2013-10-01 |
| Completed | Confirmatory Study of IK-3001 in Japanese Subjects With Peri-/Post-op Pulmonary Hypertension Assoc. With Cardi Hypertension, Pulmonary, Ventricular Dysfunction, Left | Phase 3 | 2013-09-01 |
| Terminated | Trial to Study the Safety of Intravenous MNK-010 in Advanced Solid Tumors Advanced Solid Tumors | Phase 1 | 2013-07-01 |
| Completed | A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis | Phase 2 | 2013-07-01 |
| Completed | Acthar for the Treatment of Systemic Lupus Erythematosus (SLE) in Patients With a History of Persistently Acti Systemic Lupus Erythematosus (SLE) | Phase 4 | 2013-01-01 |
| Completed | Pharmacokinetic, Bioavailability, and Safety Study of COV155 Administered in Healthy Subjects Under Fed and Fa Pharmacokinetics | Phase 1 | 2012-12-01 |
| Completed | Safety and Efficacy Study of COV155 for Post-operative Bunionectomy Pain Pain, Postoperative, Bunion | Phase 3 | 2012-11-01 |
| Completed | Open Label Safety and Tolerability Study of COV155 in Subjects With Osteoarthritis (OA) or Chronic Low Back Pa Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Low Back Pain | Phase 3 | 2012-11-01 |
| Completed | A Multi-Center Study of the Efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of IV Acetaminophen for Acute Pain | Phase 3 | 2012-06-01 |
| Completed | A Study of Fibrocaps™ in Surgical Bleeding Mild or Moderate Surgical Bleeding | Phase 3 | 2012-05-21 |
| Completed | Acthar for Treatment of Proteinuria in Diabetic Nephropathy Patients Diabetic Nephropathy | Phase 2 | 2012-05-01 |
| Completed | Pharmacokinetic, Bioavailability, and Safety Study of COV155 Administered in Healthy Subjects Under Fed and Fa Pharmacokinetics | Phase 1 | 2011-12-01 |
| Completed | Assessing Relapse in Multiple Sclerosis (ARMS) Questionnaire Multiple Sclerosis | — | 2011-12-01 |
| Completed | Extracorporeal Photopheresis (ECP) With Methoxsalen for Chronic Graft Versus Host Disease (cGVHD) Chronic Graft Versus Host Disease | EARLY_Phase 1 | 2011-11-01 |
| Completed | Safety and Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain With an Open-label Extens Pain, Postoperative, Bunion | Phase 3 | 2011-11-01 |
| Completed | Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain Osteoarthritis, Low Back Pain | Phase 3 | 2011-09-20 |
| Completed | Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Proteinuria, Idiopathic Membranous Nephropathy | Phase 4 | 2011-08-01 |
| Completed | A Study of Fibrocaps in Liver Surgery in the Netherlands Postoperative Hemorrhage | Phase 2 | 2010-12-01 |
| Completed | U.S. Study of Fibrocaps in Surgical Hemostasis Postoperative Hemorrhage | N/A | 2010-12-01 |
| Completed | A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipres Hepatorenal Syndrome | Phase 3 | 2010-10-11 |
| Completed | Pharmacokinetics, Bioavailability and Safety of PENNSAID® Gel Pain | Phase 1 | 2010-09-01 |
| Completed | Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis Osteoarthritis of the Knee | Phase 2 | 2010-08-02 |
| Withdrawn | IK-1001 (Sodium Sulfide (Na2S) for Injection) in Subjects With Acute ST-Segment Elevation Myocardial Infarctio ST-Segment Elevation Myocardial Infraction | Phase 2 | 2009-12-01 |
| Withdrawn | Inhaled Nitric Oxide (INO) In Hypoxic Respiratory Failure Hypoxic Respiratory Failure With Pulmonary Hypertension | Phase 3 | 2009-11-01 |
| Completed | Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants Bronchopulmonary Dysplasia | Phase 3 | 2009-11-01 |
| Terminated | Pharmacokinetic Assessment of Sodium Sulfide in Subjects With Impaired Renal Function Renal Impairment | Phase 1 | 2009-08-01 |
| Terminated | Reduction of Ischemia-Reperfusion Mediated Cardiac Injury in Subjects Undergoing Coronary Artery Bypass Graft Coronary Artery Bypass Surgery | Phase 2 | 2009-05-01 |
| Completed | A Double-blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic Ost Chronic Pain | Phase 3 | 2008-02-01 |
| Completed | Safety and Efficacy of Intravenous Acetaminophen (IV APAP) in Adult Inpatients Acute Pain, Fever | Phase 3 | 2008-01-01 |
| Completed | Study of the Safety & Efficacy of Intravenous Acetaminophen in Pediatric Inpatients Pain, Fever | Phase 3 | 2008-01-01 |
| Completed | Analgesic Efficacy & Safety of Intravenous (IV) Acetaminophen Versus Placebo for the Treatment of Postop Pain Pain | Phase 3 | 2007-11-01 |
| Completed | Study to Test the Effectiveness of Controlled-Release OROS® Hydromorphone HCl Compared to Placebo in Patients Chronic Low Back Pain | Phase 3 | 2007-10-01 |
| Completed | Study of the Efficacy and Safety of Intravenous vs Oral Acetaminophen for Treatment of Fever in Healthy Adult Fever | Phase 3 | 2007-08-01 |
| Withdrawn | Safety and Tolerability Study of Inhaled Carbon Monoxide in Kidney Transplant Patients Kidney Transplantation | Phase 2 | 2007-08-01 |
| Completed | Safety and Pharmacokinetic (PK) Study of Intravenous (IV) Acetaminophen Administration in Pediatric Inpatients Pain, Fever | Phase 1 | 2007-06-01 |
| Completed | Safety of Intravenous Acetaminophen Vs Placebo for the Treatment of Endotoxin-Induced Fever in Healthy Adult M Fever | Phase 3 | 2007-06-01 |
| Completed | Efficacy and Safety of Intravenous Acetaminophen Over 48 Hrs for the Treatment of Post-op Pain After Gynecolog Postoperative Pain, Hysterectomy | Phase 3 | 2006-11-01 |
| Completed | Bioequivalence of a Test Troche Formulation of Fentanyl Citrate (400 mcg) Compared to Actiq® 400 mcg, Cephalon Pain | Phase 1 | 2006-08-01 |
| Terminated | Nitric Oxide in Myocardial Infarction Size Acute Myocardial Infarction, ST Elevation MI, STEMI | Phase 2 | 2006-06-01 |
| Terminated | The Effects of Nitric Oxide for Inhalation in Right Ventricular Infarction Patients Right Ventricular Infarction | Phase 2 | 2006-03-01 |
| Terminated | Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease Acute Graft-versus-Host Disease | Phase 3 | 2006-01-01 |
| Completed | Safety and Efficacy Study of Nitric Oxide for Inhalation on Chronic Lung Disease in Premature Babies Lung Disease | Phase 3 | 2005-05-29 |
| Completed | Fasting Study of Controlled-Release Oxycodone Hydrochloride 40 mg Tablets and OxyContin® 40 mg Tablets Healthy | Phase 1 | 2005-04-01 |
| Completed | Fed Study of Controlled-Release Oxycodone Hydrochloride 40 mg Tablets and OxyContin® 40 mg Tablets Healthy | Phase 1 | 2005-04-01 |
| Completed | Safety and Efficacy Study of Nitric Oxide in Patients Going Through Lung Transplantation Lung Transplantation | Phase 2 | 2005-04-01 |
| Completed | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Crohn's Disease Crohn's Disease | Phase 2 | 2004-12-01 |
| Completed | Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Anemia, Sickle Cell | Phase 2 | 2004-10-01 |
| Completed | Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Te Idiopathic Pulmonary Arterial Hypertension, Cardiomyopathy | Phase 3 | 2004-09-01 |
| Completed | Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis Cystic Fibrosis | Phase 1 / Phase 2 | 2004-07-01 |
| Completed | Study of Terlipressin Versus Placebo to Treat Hepatorenal Syndrome Type 1 Hepatorenal Syndrome | Phase 3 | 2004-06-01 |
| Completed | Fed Study of Chlorpheniramine Polistirex and Hydrocodone Polistirex Capsules and Tussionex® Pennkinetic® Exten Healthy | Phase 1 | 2003-09-01 |
| Completed | Fasting Study of Chlorpheniramine Polistirex and Hydrocodone Polistirex Capsules and Tussionex® Pennkinetic® E Healthy | Phase 1 | 2003-09-01 |
| Completed | Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthriti Rheumatoid Arthritis | Phase 2 | 2003-08-01 |
| Terminated | Study to Evaluate the Effect of Age (Geriatric) and Kidney Function on the Safety, Efficacy and Pharmacokineti Solid Tumors | Phase 4 | 2003-07-01 |
| Completed | The Effects of Nitric Oxide for Inhalation During Left Ventricular Assists Device (LVAD) Implantation Congestive Heart Failure | Phase 2 | 2003-07-01 |
| Completed | Fed Study of Oxycodone Hydrochloride 30 mg Tablets and Roxicodone™ 30 mg Tablets Healthy | Phase 1 | 2003-02-01 |
| Completed | Fasting Study of Oxycodone Hydrochloride 15 mg Tablets and Roxicodone™ 15 mg Tablets Healthy | Phase 1 | 2003-02-01 |
| Completed | Fasting Study of Oxycodone Hydrochloride 30 mg Tablets and Roxicodone™ 30 mg Tablets Healthy | Phase 1 | 2003-01-01 |
| Completed | Fasting Study of Hydromorphone Hydrochloride 8 mg Tablets and Dilaudid 8 mg Tablets Healthy | Phase 1 | 2002-12-01 |
| Completed | Safety and Efficacy Study of Photopheresis Plus Standard Therapy to Treat Chronic Graft-versus-Host Disease Graft-versus-Host Disease | Phase 2 | 2002-06-01 |
| Completed | Safety and Efficacy Study of Photopheresis With UVADEX to Prevent Graft-versus-Host Disease Graft-versus-Host Disease | Phase 2 | 2002-06-01 |
| Terminated | Inhaled Nitric Oxide in Neonates With Elevated A-a DO2 Gradients Not Requiring Mechanical Ventilation Lung Disease, Hypoxemia, Respiratory Acidosis | Phase 1 / Phase 2 | 2002-05-01 |
| Terminated | Hospital-Based Program for Treatment of Severe Cardiopulmonary Disease With Inhaled Nitric Oxide Pulmonary Hypertension, Lung Disease, Sickle Cell Disease | Phase 2 | 2002-04-01 |
| Terminated | Effects of Inhaled Nitric Oxide in the Treatment of Acute Hypoxemic Respiratory Failure (AHRF) in Pediatrics Respiratory Insufficiency, Anoxemia | Phase 3 | 2002-01-01 |
| Terminated | Inhaled Nitric Oxide in Prevention/Treatment of Ischemia-Reperfusion Lung Injury Related to Lung Transplantati Ischemia-Reperfusion Injury | Phase 3 | 2001-08-01 |
| Approved For Marketing | Compassionate Use of Pennsaid Topical Lotion (Diclofenac) in Osteo or Rheumatoid Arthritis Osteoarthritis of the Hand | — | — |