NCT07338266

Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee

A Single Ascending Dose Study to Assess the Safety and Pharmacokinetics of Intra-articular AVD275 Injection in Patients With Osteoarthritis of the Knee

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Avidence Therapeutics · Industry
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

This study aims to understand the safety, drug concentration and distribution of an intra-articular injectable formulation of celecoxib, AVD275, in patients with knee osteoarthritis. One single injection at three different doses of the drug will be studied in a sequential order, and each participant will be monitored for 24 weeks over ten clinical visits.

Conditions

• Osteoarthritis of the Knee

Interventions

Type	Name	Description
DRUG	AVD275 Intra-articular Injection	A long-acting formulation of celecoxib

Timeline

• Start date: 2026-01-22
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2026-01-13
• Last updated: 2026-03-31

Locations

1 site across 1 country: Australia