NCT06451783

Shengyu Decoction and Lijin Manipulation for Knee OA: 3D Gait Analysis

The Clinical Efficacy of Shengyu Decoction Combined With Lijin Manipulation in the Treatment of Knee Osteoarthritis Was Observed Based on Three-dimensional Gait Analysis System

• Status: Enrolling By Invitation
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 94 (estimated)
• Sponsor: Xuhui Central Hospital, Shanghai · Academic / Other
• Sex: All
• Age: 45 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Detailed Description Avoid duplicating information that will be entered or uploaded elsewhere in the record.

Detailed description

This study aims to explore the efficacy of the Shengyu Decoction combined with manual therapy for the treatment of knee osteoarthritis (OA) using a clinical randomized controlled trial design. Additionally, based on three-dimensional gait analysis technology, the investigators will delve into the biomechanical mechanisms underlying the onset of knee OA and elucidate the mechanism of action of the Shengyu Decoction combined with manual therapy. This will further validate the clinical superiority of the Shengyu Decoction combined with manual therapy in the treatment of knee OA, providing strong support for reducing pain and improving knee function in patients with knee OA.

Conditions

• Osteoarthritis of the Knee

Interventions

Type	Name	Description
OTHER	Traditional Chinese medicine combined with manipulation treatment	The specific procedure involves administering the Shengyu Decoction, which consists of the following herbs: * Shu Di Huang 20 grams * Bai Shao 15 grams * Dang Gui 15 grams * Chuan Xiong 8 grams * Ren Shen 20 grams * Huang Qi 18 grams One dose is taken per day, and a course of treatment consists of five weeks. Add manipulation of massage： * Press and grasp the affected limb three times； * Five-finger five-acupoint pressing method； * Point pressing on Zusanli (ST36) and Sanyinjiao (SP6)； * grasp the interior method to treat the calf three times； ⑤ Apply rolling technique around the knee joint； ⑥ Knead and straighten the standing tendon (the lateral muscle of the calf)； ⑦ Six-finger six-acupoint pressing method； ⑧ Push and pull the patella to flex and extend the knee joint； ⑨ Knee joint reunion and smooth dispersion method.
DRUG	Celecoxib capsule	Oral Celecoxib Capsules, 200mg per dose, once daily after lunch.

Timeline

• Start date: 2024-05-01
• Primary completion: 2025-04-30
• Completion: 2025-12-31
• First posted: 2024-06-11
• Last updated: 2024-06-11

Locations

1 site across 1 country: China