NCT01052233

Development of Knee Osteoarthritis After Arthroscopic Partial Resection of Degenerative Meniscus Tear

Effect of Arthroscopic Partial Resection of Degenerative Meniscus Tear on Development of Knee Osteoarthritis: Which is the Chicken and the Egg?

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: Tampere University · Academic / Other
• Sex: All
• Age: 35 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

It has been previously demonstrated that the risk for the development of knee osteoarthritis is increased after both meniscus tear and meniscectomy. However, it is still unclear whether this is due to the meniscus tear per se, the surgery, or whether the development of knee osteoarthritis is completely independent of the two. Accordingly, the aim of the study is to investigate the effect of arthroscopic partial meniscectomy on the development of knee osteoarthritis 2 to 10 years after the procedure.

Detailed description

It has been previously demonstrated that the risk for the development/progression of knee osteoarthritis is increased after both meniscus tear and meniscectomy. However, it is still unclear whether this is due to the meniscus tear per se (i.e., adverse mechanical effect on knee cartilage), the surgery (resection of the meniscus, and subsequent loss of cushion within the knee), or whether the development of knee osteoarthritis is completely independent of the two. Accordingly, the aim of the study is to investigate the effect of Arthroscopic partial meniscectomy on the development of knee osteoarthritis 2 to 10 years after the procedure. Patients included in the study will be randomized into one of two groups: arthroscopic partial meniscectomy and diagnostic arthroscopy (sham-surgery). The presence of knee osteoarthritis will be assessed preoperatively and 2, 5, and 10 years after the operation.

Conditions

• Osteoarthritis of the Knee
• Arthroscopy
• Meniscal Tear

Interventions

Type	Name	Description
PROCEDURE	Arthroscopic partial meniscectomy	Arthroscopic partial meniscectomy of the degenerative tear of medial meniscus
PROCEDURE	Arthroscopy (diagnostic)	Diagnostic arthroscopy of the knee

Timeline

• Start date: 2010-01-01
• Primary completion: 2016-01-01
• Completion: 2024-01-01
• First posted: 2010-01-20
• Last updated: 2015-01-21

Locations

5 sites across 1 country: Finland