| Recruiting | Impact of Bone-Marrow Aspirate Injections in Knee Arthroscopy NCT06893302 | Hospital for Special Surgery, New York | N/A |
| Not Yet Recruiting | Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoa NCT07522489 | Medical University of Warsaw | N/A |
| Not Yet Recruiting | The GORUN Study: Gradual Onset of RUNning and Knee Joint Health in Novice Runners NCT07528885 | University of British Columbia | N/A |
| Not Yet Recruiting | Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of NCT06865170 | University of California, Davis | Phase 4 |
| Not Yet Recruiting | Ketogenic Diet to Reduce Osteoarthritis Pain in MCI NCT07417891 | University of Kansas Medical Center | N/A |
| Not Yet Recruiting | Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA NCT07430085 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | Phase 4 |
| Recruiting | Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis NCT07178951 | FUSMobile Inc. | N/A |
| Not Yet Recruiting | Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Adv NCT07323745 | Universiti Sains Malaysia | EARLY_Phase 1 |
| Recruiting | Platelet Rich Plasma for Musculoskeletal Conditions NCT07231471 | University of Utah | N/A |
| Recruiting | The Effectiveness of a Herbal Supplement in Osteoarthritis. NCT07324746 | Middlesex University | N/A |
| Not Yet Recruiting | Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty NCT07219888 | University of Louisville | Phase 4 |
| Completed | Counterpain PXM Versus Diclofenac Versus Piroxicam NCT07475663 | Taisho Pharmaceutical Indonesia | Phase 3 |
| Not Yet Recruiting | Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity NCT07065591 | The University of Hong Kong | EARLY_Phase 1 |
| Recruiting | Mako Cementless TKA vs Mako Cemented TKA NCT06929871 | University College, London | N/A |
| Not Yet Recruiting | Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist NCT06807970 | The University of Hong Kong | EARLY_Phase 1 |
| Recruiting | Pharmacist-physiotherapist Collaborative Management for Early Knee Osteoarthritis NCT06681142 | University of Alberta | N/A |
| Completed | Effectiveness of Stanley Paris Manual Therapy vs. Conventional Physiotherapy in Reducing Pain and Improving Fu NCT07317375 | Ibadat International University, Islamabad | N/A |
| Not Yet Recruiting | A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches NCT07085520 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 1 |
| Recruiting | Feasibility of Choose to Move Replacement Ready NCT07069179 | University of British Columbia | N/A |
| Active Not Recruiting | 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe NCT06865079 | OrthoTrophix, Inc | Phase 2 |
| Completed | Knee Pain and Lumbar Proprioception in Knee Osteoarthritis Patients NCT07436897 | Cairo University | — |
| Not Yet Recruiting | Antarctic Krill Oil for Knee Osteoarthritis Pain NCT06880926 | Qilu Hospital of Shandong University | Phase 2 |
| Terminated | Genicular Artery Embolization (GAE) vs inTra-articular Corticosteroid Injection for Osteoarthritic Knee Pain. NCT06929585 | National Taiwan University Hospital | N/A |
| Enrolling By Invitation | LinkSymphoKnee (LSK) Total Knee Replacement System Study - Ultra-congruent (UC) NCT06670651 | LinkBio Corp. | — |
| Enrolling By Invitation | The Effects of Knee Brace and Muscle Training on Osteoarthritis Patients NCT07246109 | China Medical University Hospital | N/A |
| Not Yet Recruiting | Investigation of Biopsychosocial Characteristics of Individuals with Knee Osteoarthritis NCT06591715 | Aysima Barlak | — |
| Active Not Recruiting | A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee NCT06884865 | Pacira Pharmaceuticals, Inc | Phase 2 |
| Recruiting | Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department NCT06603662 | WellSpan Health | Phase 4 |
| Recruiting | The Efficacy of Transcutaneous Pulsed Radiofrequency Acupuncture for Knee Osteoarthritis NCT06702046 | Shin Kong Wu Ho-Su Memorial Hospital | N/A |
| Recruiting | Clinical Study of Acupuncture Treatment of Knee Osteoarthritis NCT06805188 | Wu zenan | N/A |
| Not Yet Recruiting | Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA NCT06726993 | Assiut University | N/A |
| Recruiting | COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty NCT06809998 | Unity Health Toronto | Phase 1 / Phase 2 |
| Recruiting | The Effects of Functional Electrical Stimulation (FES) and Exercise on the Quadriceps in Patients With Knee Os NCT07309003 | Ankara City Hospital Bilkent | — |
| Terminated | Native Alignment in the Setting of an Arthritic Knee in Total Knee Arthroplasty NCT06617338 | University of Louisville | N/A |
| Active Not Recruiting | INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE NCT06700109 | Brixton Biosciences, Inc. | N/A |
| Enrolling By Invitation | Long-term Follow up of the Stability 1 Trial NCT06885372 | Western University, Canada | N/A |
| Recruiting | Effects of Different Relaxation Therapies on Pain and Sleep in Hip and Knee Arthroplasty Patients NCT07354542 | Bartın Unıversity | N/A |
| Recruiting | Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns NCT06596824 | Charite University, Berlin, Germany | N/A |
| Completed | Postoperative Pain and Analgesic Requirements After Preoperative Methadone for Primary TKA NCT06691633 | University of Louisville | Phase 4 |
| Completed | First in Human Study of SakuraBead for Genicular Artery Embolization to Treat Pain Secondary to Knee Osteoarth NCT06718478 | CrannMed | N/A |
| Completed | Comparing Exercise Programs for Managing Knee Osteoarthritis NCT06711341 | Uludag University | N/A |
| Completed | Clinical-randomized Study of the Influence of Rehabilitation Therapy Using Strength and Blood Flow Restriction NCT06942065 | University Hospital, Bonn | N/A |
| Completed | Impact of Blood-Flow-Restriction Prehabilitation on Pre- and Postoperative Rehabilitation After Total Knee Art NCT06964022 | University Hospital, Bonn | N/A |
| Completed | Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis NCT06717529 | Edin Mešanović | Phase 4 |
| Completed | To Assess the Safety and Effectiveness of Hyruan ONE Versus a Comparator for the Treatment of Knee Osteoarthri NCT04732793 | LG Chem | N/A |
| Completed | Effect of Different Size of Patellar Resurfacing on Patellar Crepitus of the One-stage Bilateral Total Knee Ar NCT06811506 | Thammasat University | N/A |
| Completed | Photographic Evidence on Total Knee Arthroplasty Outcomes NCT07223359 | Loyola University | N/A |
| Unknown | Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-contro NCT03734900 | National Taiwan University Hospital | Phase 4 |
| Completed | 2ccPA Study in Patients With Symptomatic Knee Osteoarthritis NCT04229394 | Orient Europharma Co., Ltd. | Phase 1 |
| Active Not Recruiting | Does the Use of Patient Specific Instrumentation Improve Outcomes in Knee Arthroplasty Surgery for Osteoarthri NCT06720012 | Vastra Gotaland Region | N/A |
| Completed | Effect of Steroid Injections in a Knee With Osteoarthritis NCT01230424 | Tufts Medical Center | Phase 4 |