Trials / Unknown
UnknownNCT03734900
Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial
Comparison of Effectiveness Between Platelet Lysate and Platelet-rich Plasma on Knee Osteoarthritis: a Prospective, Randomized, Placebo-controlled Trial
- Status
- Unknown
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- Sponsor
- National Taiwan University Hospital · Academic / Other
- Sex
- All
- Age
- 50 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.
Detailed description
The current methods for treating knee osteoarthritis include delaying the disease progression and joint replacement surgery. The usual treatment methods are mostly temporary, such as taking drug and hyaluronic acid injection. Therefore, finding the safe and effective methods will greatly reduce medical resource, medical expenses and surgery cost, etc., and restore the patient's quality of life. Platelet lysate is the product of complete activation from autologous platelet. It contains rich growth factors and cytokines such as PDGF, TGF-β, VEGF, EGF and IGF, etc. It can support cell growth and doesn't have any white blood cells in it. It is superior to the platelet rich plasma because of reducing the overall inflammatory response and pain of the patient during treatment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Saline injection | 5ml Placebo infusion of 0.9% Sodium Chloride |
| BIOLOGICAL | PRP injection | Device: "Aeon" Acti-PRP 5ml autologous platelet rich plasma injection |
| BIOLOGICAL | PL injection | Device: "Aeon" Acti-PRP 5ml autologous platelet lysate injection |
Timeline
- Start date
- 2018-05-15
- Primary completion
- 2022-05-14
- Completion
- 2022-05-14
- First posted
- 2018-11-08
- Last updated
- 2021-09-20
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT03734900. Inclusion in this directory is not an endorsement.