Trials / Conditions / Osteoarthritis, Knee

Osteoarthritis, Knee

1,018 registered clinical trials studyying Osteoarthritis, Knee — 95 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis. NCT05454566	ICM Co. Ltd.	Phase 1 / Phase 2
Not Yet Recruiting	Boosting Exercise Adherence in Knee Osteoarthritis NCT07219732	VA Office of Research and Development	N/A
Not Yet Recruiting	Feasibility of Good Boost+ for Adults Awaiting Total Knee Replacement NCT07532785	King's College Hospital NHS Trust	N/A
Not Yet Recruiting	AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weigh NCT07509307	Novo Nordisk A/S	Phase 3
Not Yet Recruiting	Cooling of the Knee After Total Knee Arthroplasty NCT07416721	Clinical Center of Vojvodina	N/A
Not Yet Recruiting	Single vs Triple Hyaluronic Acid in Knee Osteoarthritis NCT07352540	University of Erlangen-Nürnberg Medical School	Phase 2 / Phase 3
Recruiting	Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans NCT06488144	VA Office of Research and Development	Phase 3
Not Yet Recruiting	PPV-06 Vaccine in Inflammatory Knee Osteoarthritis NCT06605963	Peptinov SAS	Phase 2
Not Yet Recruiting	Phase 4 Study of Laybon Tab. in Knee Osteoarthritis NCT07203547	Mather's Pharm. Co., Ltd.	Phase 4
Active Not Recruiting	Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty NCT07386561	Wroclaw University of Health and Sport Sciences	N/A
Recruiting	Wound Closure Materials and Techniques in Hip and Knee Arthroplasty NCT07439575	Bahattin Kemah	N/A
Recruiting	Study to Evaluate the Performance of Navigated TKA With OrthoPilot® pheno4u TKA Level 1 NCT06955481	Aesculap AG	—
Not Yet Recruiting	Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty NCT06951477	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	—
Active Not Recruiting	Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) NCT07514598	Fatih Sultan Mehmet Training and Research Hospital	N/A
Recruiting	Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement NCT07058623	Hospital Authority, Hong Kong	N/A
Not Yet Recruiting	Can Multimodal Medical Strategies Can Delay Total Knee Replacement? NCT06643845	University Hospital, Brest	N/A
Not Yet Recruiting	Robotic-assisted (MAKO) Versus Manual Total Knee Arthroplasty for Knee Osteoarthritis NCT07201207	Satakunta Central Hospital	N/A
Recruiting	Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty NCT07180953	Poznan University of Medical Sciences	Phase 4
Recruiting	Promoting Sleep to Alleviate Pain - Arthroplasty NCT06145516	Uppsala University	N/A
Not Yet Recruiting	Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin NCT07047040	Assiut University	Phase 2 / Phase 3
Recruiting	FiH Safety and Feasibility Study Assessing Intra-articular Administration of aeGF in Patients With Knee Osteoa NCT06690710	Scarcell Therapeutics S.A.S.	Phase 1
Enrolling By Invitation	Rate of Allergic Contact Dermatitis and Cosmetic Outcomes NCT06957444	West Virginia University	N/A
Recruiting	Analysis of the Pathophysiological and Functional State of the Knee Joint NCT06490770	Istituto Ortopedico Rizzoli	N/A
Not Yet Recruiting	Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Random NCT07052851	Lipo-Sphere	N/A
Withdrawn	Gait Retraining for Runners With Knee Osteoarthritis NCT03314428	University of British Columbia	N/A
Recruiting	Oral Steroid Taper After Total Knee Arthroplasty NCT07070882	Columbia University	Phase 1
Recruiting	Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial NCT06887829	Mayo Clinic	N/A
Completed	Adductor Canal Block Combined With Local Infiltration Analgesia vs Local Infiltration Analgesia Alone for Post NCT07517159	Ankara University	N/A
Recruiting	A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared NCT06917404	Paradigm Biopharmaceuticals Ltd.	Phase 3
Not Yet Recruiting	Single-Dose Hybrid Hyaluronic Acid and Sodium Chondroitin with Rehabilitation for Sports Adults with Knee Oste NCT06890247	University of Palermo	—
Not Yet Recruiting	Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofreque NCT06858228	Federal University of São Paulo	N/A
Not Yet Recruiting	Telerehabilitation for Hip and Knee Osteoarthritis NCT06901661	Taipei Medical University Shuang Ho Hospital	N/A
Not Yet Recruiting	3-point vs 6-point GNRFA for Chronic KOA NCT05930756	McMaster University	N/A
Active Not Recruiting	A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms NCT06693648	Amzell	Phase 3
Recruiting	Positive Minds Strong Joints for Knee Osteoarthritis NCT06493903	Boston University Charles River Campus	N/A
Recruiting	Probiotic Supplements in Osteoarthritis NCT07364578	Beni-Suef University	Phase 3
Recruiting	MOTION Clinical Trial NCT06843980	Moximed	N/A
Suspended	Human Growth Hormone Injections in the Knee Joint to Treat Osteoarthritis NCT06354023	John Sledge	Phase 2
Active Not Recruiting	Effects of Including Interferential Current in a Therapeutic Exercise Program in Individuals With Knee Osteoar NCT06744036	University of Nove de Julho	N/A
Recruiting	Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA NCT05517434	University Health Network, Toronto	Phase 2 / Phase 3
Not Yet Recruiting	Knee Osteoarthritis and IPACK NCT06712394	Sakarya University	—
Recruiting	The Effect of ColcHicine on the Incidence of Knee or Hip Replacements NCT06578182	Sint Maartenskliniek	Phase 3
Withdrawn	Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects NCT04435704	Wake Forest University Health Sciences	Phase 2
Recruiting	Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplast NCT06083480	Vanderbilt University Medical Center	Phase 4
Completed	Baseline Predictors of Response to Radial Pressure Wave Therapy in Knee Osteoarthritis NCT07531160	Hospital Civil de Guadalajara	—
Recruiting	Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA) NCT06191848	University of Melbourne	Phase 4
Recruiting	Mobilizing Hispanics With Knee Osteoarthritis NCT06522906	University of Arizona	N/A
Completed	Intra-articular Tenoxicam Versus Triamcinolone Acetonide in Knee Osteoarthritis Management NCT07194135	Benha University	N/A
Withdrawn	The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study NCT05735873	Vanderbilt University Medical Center	N/A
Active Not Recruiting	Clinical Study to Evaluate Efficacy and Safety of ANT-301 in Patients With Knee Osteoarthritis in Grade III/IV NCT06539429	Anterogen Co., Ltd.	Phase 1
Completed	Effect of Baduanjin on Individuals With Knee Osteoarthritis NCT06650865	Biruni University	N/A
Not Yet Recruiting	Effect of Low Intensity Training Combined With Partial Restriction of Blood Flow in Individuals With Knee Oste NCT04819672	Universidade Federal do Ceara	N/A
Not Yet Recruiting	The Safety and Pharmacokinetics of ASKC200 in Osteoarthritic Knee Pain NCT06614608	Jiangsu Aosaikang Pharmaceutical Co., Ltd.	Phase 1
Recruiting	Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Knee Osteoarthritis NCT06608134	R3 Medical Research	EARLY_Phase 1
Recruiting	Comparative Study of CT and Fluoroscopic Guided Genicular Nerve Ablation in the Treatment of Knee Osteoarthrit NCT06514703	Zagazig University	N/A
Recruiting	Development of Computational Models to Predict the Short-, Medium- and Long-term Cartilage Degeneration and Pa NCT07134244	Aalborg University	—
Enrolling By Invitation	Orthobiologic Treatment for Knee Osteoarthritis NCT06893250	University Hospital of North Norway	Phase 2 / Phase 3
Recruiting	Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes NCT06478186	University of Kansas Medical Center	Phase 4
Not Yet Recruiting	Knee Osteoarthritis Treatment With Platelet-rich Plasma NCT05824806	Instituto Nacional de Traumatologia e Ortopedia	Phase 3
Not Yet Recruiting	Barriers and Faciliators for Physical Activity in People With RMDs NCT06514443	Anne-Kathrin Rausch	—
Completed	Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoar NCT06622512	Hospital Civil de Guadalajara	N/A
Recruiting	Embo Registry; National Registry for Artery Embolization NCT06477965	Vascular Solutions of North Carolina	—
Recruiting	Quantitative Assessment of BB-02 Therapy Effect on Cartilage Status in Patients Affected by Early Knee Osteoar NCT06459817	Istituto Ortopedico Rizzoli	N/A
Recruiting	Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee Arthroplasty NCT05980442	Aesculap AG	—
Not Yet Recruiting	Comparison Between TOMOFIX and BodyCAD Fine Osteotomy NCT06250530	Western University, Canada	N/A
Active Not Recruiting	Light Therapy and MRI Imaging for Knee Osteoarthritis Pain NCT06395584	Nova Scotia Health Authority	N/A
Recruiting	Efficacy and Safety of Liposomal Bupivacaine Using Periarticular Injection in Total Knee Arthroplasty NCT06557018	Dezhou Hospital Qilu Hospital of Shandong University	Phase 4
Completed	OrthoCor Advanced Trial for Knee Osteoarthritis NCT06475677	Caerus Corporation	N/A
Recruiting	CBD for Knee Osteoarthritis NCT06414473	University of Florida	Phase 1 / Phase 2
Completed	Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthri NCT06263270	Cytonics Corporation	Phase 1
Recruiting	Knowledge Translation and Exercise for Degenerative Meniscal Tears and Early Osteoarthritis: KNEE-DEeP Study NCT06576557	University of Limerick	N/A
Completed	Effects of Ultrasound-guided Genicular Nerve Block in Knee Osteoarthritis Patients on Proprioception and Stati NCT06527651	Ankara City Hospital Bilkent	N/A
Not Yet Recruiting	Magnesium Sulfate Combined With Intraarticular Cocktail Injection for Analgesia After Simultaneous Bilateral T NCT06445829	Chang Gung Memorial Hospital	N/A
Active Not Recruiting	Effects of Including a Chronic Pain Neuroscience Education Program for Individuals With Knee OA NCT06187038	University of Nove de Julho	N/A
Completed	Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis NCT06229691	University of Delaware	N/A
Recruiting	Interventistic Clinical Investigation on the Use of Medical Device in Subjects With Mild-moderate Osteoarticul NCT06422169	PromoPharma spa	N/A
Recruiting	Preventing Injured Knees From osteoArthritis: Severity Outcomes NCT06096259	Brigham and Women's Hospital	Phase 2
Recruiting	Analysis of Articular Biomarkers From Osteoarthritic Thumb Basal Joints NCT06370312	Region Skane	—
Recruiting	Stopping OsteoARthritis After an ACL Tear NCT06195423	University of British Columbia	N/A
Active Not Recruiting	Effectivity of Allogenic Umbilical Cord Mesenchymal Stem Cells Conditioned Media for Osteoarthritis of the Kne NCT06688318	Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia	Phase 1 / Phase 2
Unknown	Evaluation of the Effectiveness of Manual Therapy in Patients With Knee Osteoarthritis NCT06329128	Hasan Kalyoncu University	N/A
Recruiting	The Osteoarthritis Prevention Study NCT05946044	Wake Forest University	N/A
Recruiting	L-arginine for Knee Osteoarthritis Patients NCT06054633	Xiangya Hospital of Central South University	N/A
Completed	Dry Needling and Exercise Program in Osteoarthritis NCT06816940	Manuel Albornoz Cabello	N/A
Unknown	Efficacy and Mechanism of FSN Treatment for Senile Knee Osteoarthritis NCT06328153	Guangdong Provincial Hospital of Traditional Chinese Medicine	N/A
Recruiting	Comparing Efficacy Between Restricted Kinematic Alignment vs Mechanical Alignment in Bilateral TKA NCT06323577	Thammasat University Hospital	N/A
Recruiting	Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty NCT06234631	Chad Brummett	Phase 2
Active Not Recruiting	Kinesiological / Dietary Supplement Intervention in Knee Osteoarthritis NCT06269549	University of Primorska	N/A
Recruiting	Effects of TENS During the Performance of a Therapeutic Exercise Protocol in Individuals With Knee Osteoarthri NCT06184451	University of Nove de Julho	N/A
Completed	Impact of Mulligan Squeeze Technique on Meniscal Derangement in Knee Osteoarthritis Patients NCT06391047	University of Faisalabad	N/A
Active Not Recruiting	Study of Intra-articular Allocetra in Knee Osteoarthritis NCT06233474	Enlivex Therapeutics Ltd.	Phase 1 / Phase 2
Completed	Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects NCT06249828	L&C Bio	N/A
Recruiting	Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis NCT06208631	Stanford University	N/A
Completed	A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthriti NCT05337540	Aptissen SA	N/A
Unknown	Oral Fluid vs IV Fluid After Primary TKA NCT06288815	Thammasat University Hospital	N/A
Recruiting	Transforming Rehabilitation: Personalised Care for a Better Quality of Life NCT06249958	I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio	—
Withdrawn	A Pilot Feasibility Study of IM OXT on Fear of Pain and Trust in Physical Therapist During OP Rehabilitation A NCT04493229	Wake Forest University Health Sciences	Phase 2
Recruiting	Mesenchymal Stem Cells Derived Exosomes in Osteoarthritis Patients NCT06466850	Isfahan University of Medical Sciences	N/A
Not Yet Recruiting	Physiotherapist Led Triage in Primary Care for Patients With Hip or Knee OA NCT06187116	Vastra Gotaland Region	N/A
Recruiting	Helping Osteoarthritis Patients to Walk With NSAID NCT05761015	University Hospital, Clermont-Ferrand	Phase 4
Withdrawn	Estimate Serum Oxytocin PD Range in the Periphery NCT04431193	Wake Forest University Health Sciences	Phase 2
Unknown	Study on the Safety and Tolerance of Mesenchymal Stem Cells Mediated by Arthroscopy in Patients With Osteoarth NCT06082440	First Affiliated Hospital of Wannan Medical College	EARLY_Phase 1
Unknown	Constitutional Alignment in Osteoarthritic and Healthy Chinese NCT06158425	The First Hospital of Jilin University	—
Recruiting	The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty NCT05800457	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	N/A
Terminated	Temporary Peripheral Nerve Stimulation System for Osteoarthritis of the Knee NCT06152029	Wake Forest University Health Sciences	—
Completed	Melatonin for Knee Osteoarthritis Patients NCT06012175	Xiangya Hospital of Central South University	N/A
Unknown	An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Kn NCT05789719	StemMedical A/S	Phase 1
Recruiting	3D Joint Space Evaluation in Knee Osteoarthritis: The Importance of Weight-bearing and Flexion NCT05950854	Mylène Jansen	—
Not Yet Recruiting	Finding the Optimal Aim of Correction in Opening Wedge High Tibial Osteotomy NCT06134050	Vestre Viken Hospital Trust	N/A
Unknown	Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections NCT06000709	University of Manitoba	Phase 4
Recruiting	Partial Synovectomy in Articular Side of Quadriceps Tendon Verified to Reduce Crepitus in Retrospective Study NCT06129214	Gangnam Severance Hospital	N/A
Recruiting	Mechanically or Kinematically Aligned Total Knee Prosthesis NCT06158646	Clinique du Sport, Bordeaux Mérignac	N/A
Recruiting	Effect of Structured Exercise in Patients With Knee Osteoarthritis NCT06084949	The Hong Kong Polytechnic University	N/A
Recruiting	Effect of Anti-inflammatory Diet in Osteoarthritis NCT06080347	University of California, San Diego	N/A
Completed	A Comparison of 2-octyl Cyanoacrylate Skin Adhesive and Polyester Mesh for Wound Closure in Total Knee Arthrop NCT06232018	Pooriwat Lertsurawat	N/A
Not Yet Recruiting	Autologous Adipose Tissue-Derived Mesenchymal Stem Cells (AdMSCs) for Osteoarthritis NCT04448106	Celltex Therapeutics Corporation	Phase 2
Terminated	A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) NCT05838742	GlaxoSmithKline	Phase 2
Unknown	Biomechanics and Clinical Outcomes in Responders and Non-Responders NCT06080763	Mahidol University	—
Unknown	Effects of Perioperative Intravenous Dexamethasone in Clinical Outcomes After Total Knee Arthroplasty in a His NCT06042426	University of Puerto Rico	Phase 4
Recruiting	Knee Osteotomy Associated With Allograft Meniscus Transplantation NCT05840887	Istituto Ortopedico Rizzoli	N/A
Unknown	Effects of Home Based Resistance Training as Compared to Supervised Resistance Training Exercise in the Manage NCT06076278	Foundation University Islamabad	N/A
Unknown	Investigation of the Effects of Progressive Resistance Exercises in Individuals With Knee Osteoarthritis NCT05997966	Meltem Meran Çağlar	N/A
Completed	Effect of Whole Body Vibration Therapy on Pain, Muscle Strength, Balance and Quality of Life in Knee Osteoarth NCT06542692	Burak Çetinkaya	N/A
Unknown	Combination of Curcuminoid With Acupressure for Inflammation and Pain in the Elderly With Osteoarthritis Genu NCT06105840	Gadjah Mada University	Phase 1 / Phase 2
Completed	Does Rehabilitation After Total Knee Arthroplasty Work? - Feasibility Trial NCT05935020	Copenhagen University Hospital, Hvidovre	N/A
Completed	Effect of Patellar Denervation on Post-operative Knee Pain and Knee Function in Total Knee Arthroplasty NCT07342166	Queen Savang Vadhana Memorial Hospital, Thailand	N/A
Recruiting	Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee NCT05700682	Palo Alto Veterans Institute for Research	—
Active Not Recruiting	A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight NCT05929066	Eli Lilly and Company	Phase 3
Unknown	A Hip Flexion Feedback System for Exercise Monitoring in Individuals With Osteoarthritis and Obesity NCT05997862	University of Southern Mississippi	Phase 1 / Phase 2
Recruiting	Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty) NCT05787821	Zimmer Biomet	—
Terminated	A 12-Week Home-Based Electrical Stimulation Program for Strength in Adults With Knee Osteoarthritis NCT05765435	Cionic, Inc.	N/A
Completed	Study on Structum® in Adult Patients With Osteoarthritis (TRUST) NCT06623773	Pierre Fabre Medicament	—
Completed	Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pa NCT04814719	Paradigm Biopharmaceuticals Ltd.	—
Completed	Clinical Trial to Evaluate the Regeneration of Articular Cartilage Through Arthroscopy After MegaCarti® Applic NCT06278480	L&C Bio	—
Active Not Recruiting	Core Stabilization Exercises in Patients with Knee Osteoarthritis NCT06621784	Istanbul Physical Medicine Rehabilitation Training and Research Hospital	N/A
Active Not Recruiting	Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis NCT05835895	Genascence Corporation	Phase 1
Completed	Efficacy of UniRelieverTM Offloading Brace in the Management of Knee Osteoarthritis NCT05905809	Thuasne	N/A
Active Not Recruiting	Effects of Multicomponent Exercise on Subchondral Bone and Cartilage in Postmenopausal Women with Knee Osteoar NCT06173193	University of Jyvaskyla	N/A
Completed	Pain Neuroscience Education in Patients With Total Knee Arthroplasty NCT05928351	Ahi Evran University Education and Research Hospital	N/A
Unknown	Evaluation of Product Effectiveness of the Intervention for Patients With Knee Osteoarthritis NCT06220565	Shanghai Jiao Tong University School of Medicine	N/A
Withdrawn	Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE) NCT04770064	Austin V Stone	Phase 1 / Phase 2
Completed	Safety and Efficacy of RHH646 for Knee Osteoarthritis NCT05816395	Novartis Pharmaceuticals	Phase 2
Completed	Effects of Aromatherapy Massage in Menopausal Women With Knee Osteoarthritis NCT05823077	KTO Karatay University	N/A
Unknown	Comparison of Progressive Motor Imagery and Sensorimotor Exercises in Knee Osteoarthritis NCT05850793	Istanbul Medipol University Hospital	N/A
Completed	Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty NCT05673720	Florida State University	N/A
Completed	Video Exercise Mobile Application for People With Knee Osteoarthritis NCT06422910	Fatih Ozden	N/A
Completed	Evaluation of the Effect of Triamcinolone at Different Doses on LIA During TKA NCT05997238	Peking University Third Hospital	Phase 4
Completed	Investigating the Impact of a Shared Decision-Making Tool NCT05411939	Yale University	N/A
Completed	Effects of Improved Calf Muscle Function on Gait, Balance and Joint Loading in Older Adults NCT03921801	University of Eastern Finland	N/A
Terminated	Late-initiated Blood Flow Restricted Rehabilitation Exercises After Total Knee Replacement NCT05770934	University of Aarhus	N/A
Completed	Active Video Games for Older Adults With Knee and/or Hip Osteoarthritis. NCT05839262	Cristian Alvarez	N/A
Recruiting	Clinical Efficacy and Safety of Robot-assisted Total Knee Arthroplasty NCT06856356	The First Affiliated Hospital of University of Science and Technology of China	N/A
Unknown	Effects of Digital-based Physical Activity Intervention in Individuals With Knee Osteoarthritis NCT05810376	Trakya University	N/A
Unknown	Intra-articular Platelet Rich Plasma vs Corticosteroid in Treatment of Knee Osteoarthritis Patients NCT05742061	Benha University	EARLY_Phase 1
Completed	Personalised Modeling and Simulations for the Differential Diagnosis of Dynapenia: Study on Patients With Oste NCT05795348	Istituto Ortopedico Rizzoli	N/A
Completed	Mechanisms of Palmitoylethanolamide (PEA) to Alter Pain Sensitivity in Knee Osteoarthritis NCT05406726	University of Maryland, Baltimore	N/A
Enrolling By Invitation	A Long Term Follow-up Study of Subjects Who Received ICM-203 or Matching Placebo NCT05752032	ICM Co. Ltd.	—
Recruiting	ZYNRELEF for Pain Management in Total Knee Arthroplasty NCT05644496	Baptist Health South Florida	Phase 4
Completed	Spinal Anaesthesia vs. General Anaesthesia for THA, TKA and UKA NCT05706844	Anders Troelsen	Phase 4
Unknown	Transcutaneous Vagal Stimulation in Knee Osteoarthritis NCT04381624	Universidad de La Frontera	N/A
Active Not Recruiting	Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty NCT05678231	Prisma Health-Midlands	N/A
Unknown	Comparing Pain Outcomes of Treatment Strategies for Osteoarthritis Knee Patients NCT05700253	Changi General Hospital	N/A
Unknown	Simultaneous Physiotherapy and Orthopedic Surgeon Interdisciplinary Care (SPOSIC) NCT05664724	University of British Columbia	N/A
Completed	Effect of Knee Pain on Walking Biomechanics NCT05670236	The Cleveland Clinic	Phase 4
Unknown	Evaluation and Characterisation of Microplastics and Nanoplastics in Joint Synovial Liquid NCT05678049	Iuliu Hatieganu University of Medicine and Pharmacy	—
Completed	A Proof of Science, Dose-Response Study to Evaluate the Safety, Efficacy of Different Dosages of Test Treatmen NCT05613660	NovoBliss Research Pvt Ltd	N/A
Completed	Engaging African American Older Adults With Arthritis in a Physical Activity Intervention NCT05652413	Duke University	N/A
Completed	Do Taping and Orthosis Affect Pain, Gait, or Functionality in Mild Knee Osteoarthritis? NCT05741996	Hacettepe University	N/A
Active Not Recruiting	Acoustic Emission Biomarkers for the Detection and Monitoring of Early Knee Osteoarthritis NCT06351059	Schulthess Klinik	—
Not Yet Recruiting	Evaluation of Safety and Efficacy of Wharton's Jelly Compared to Hyaluronic Acid and Saline for Knee Osteoarth NCT04711304	BioIntegrate	Phase 1 / Phase 2
Completed	Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis NCT06717529	Edin Mešanović	Phase 4
Withdrawn	A Study of Oxytocin PK After IV Administration in Healthy Subjects and Advanced Knee Arthritis Subjects NCT04429880	Wake Forest University Health Sciences	Phase 2
Unknown	Umbilical Cord Derived Wharton's Jelly for Knee Osteoarthritis NCT04719793	BioIntegrate	EARLY_Phase 1
Unknown	Cell-free Stem Cell-derived Extract Formulation for Knee Osteoarthritis NCT04971798	General Therapeutics	EARLY_Phase 1
Completed	A Study of the Construct Validity of Community Walking Speed Data Collected Remotely With the Canary canturioT NCT05539326	Canary Medical	—
Terminated	Radiofrequency Ablation and Steroid Versus Steroid Alone for Relief of Pain in Patients With Advanced Knee and NCT05490355	University of Texas Southwestern Medical Center	N/A
Completed	Effects of Low Impact Elliptical Training on Knee Osteoarthritis Outcomes. NCT05977374	Riphah International University	N/A
Completed	Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage NCT07110402	eMKa MED Medical Center	N/A
Recruiting	Digitalization of Osteoarthritis Care NCT05584410	Vastra Gotaland Region	N/A
Completed	The Effect of Contralateral Isokinetic Lower Extremity Exercises in Unilateral Painful Knee Osteoarthritis NCT06675318	Gazi University	N/A
Active Not Recruiting	Patients' Perceptions of Assessment and Treatment of Knee Osteoarthritis in Primary Care NCT05566925	Vastra Gotaland Region	—
Unknown	Arthrosamid Injection for OA Knee NCT05086068	Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust	N/A
Completed	The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Knee Osteoarthrit NCT05605444	Taif University	N/A
Completed	Monopolar Versus Biopolar Radiofrequency in OA Knee Pain NCT05591768	Assiut University	N/A
Terminated	A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA NCT05462990	Novartis Pharmaceuticals	Phase 2
Unknown	A Study to Evaluate the Safety and Efficacy of 2ccPA in Patients With Symptomatic Knee Osteoarthritis NCT05807529	Orient Europharma Co., Ltd.	Phase 1 / Phase 2
Terminated	Medial Peel Release Technique TKA Randomized Clinical Trial NCT05154058	Emory University	N/A
Completed	Mechanisms of Treatment Effects Using Cultured, Allogeneic Mesenchymal Stromal Stem Cells (MSCs) in Knee Osteo NCT06078059	University Medical Centre Ljubljana	N/A
Terminated	FibroFix Cartilage P Knee Implant Study NCT05560490	Orthox Limited	N/A
Completed	Study of StimRouter for Chronic Knee OA Pain NCT05644639	Bioventus LLC	—
Completed	Pain Relief Effect of Low-intensity Continuous Ultrasound Stimulator for Knee Arthritis NCT05657535	Kyu Jae Lee	N/A
Withdrawn	Comparison of CoCr Alloy and TiN Coating in TKA NCT04701359	Medical University of Graz	N/A
Terminated	Total Joint Arthroplasty (TJA) Weight Loss Study NCT05156762	Boston Medical Center	N/A
Unknown	Understanding Pain Mechanisms in Knee Osteoarthritis NCT05561010	Nottingham University Hospitals NHS Trust	N/A
Unknown	Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty NCT05559268	The Affiliated Hospital of Qingdao University	Phase 4
Active Not Recruiting	Bayer OA Knee Pain Pilot NCT05349682	Medical University of South Carolina	N/A
Unknown	Effect of Mesenchymal Stem Cells in Primary Knee Osteoarthritis NCT05783154	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Phase 2 / Phase 3
Recruiting	Triamcinolone Ketorolac (TriKe) Knee Trial NCT05336968	United Health Services Hospitals, Inc.	Phase 4
Unknown	Mesenchymal Stem Cells for The Treatment of Knee Osteoarthritis (KOA). NCT04893174	Meridigen Biotech Co., Ltd.	Phase 1
Terminated	Astaxanthin for Management of Inflammation in Knee Osteoarthritis NCT05138549	Prisma Health-Midlands	Phase 2 / Phase 3
Unknown	Effects of Different Telerehabilitation Methods on Pain, Functional Limitation, Muscle Strength, Balance, and NCT05514704	Marmara University	N/A
Unknown	Comparison Between Robotic-arm Assisted Total Knee Replacement and Traditional Total Knee Replacement NCT05391152	Second Affiliated Hospital, School of Medicine, Zhejiang University	N/A
Active Not Recruiting	Prospective Randomized Study of Cementless vs Cemented UKA NCT05377450	JIS Research Institute	N/A
Active Not Recruiting	Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis NCT05430230	Northwestern University	Phase 4
Unknown	Heat and Acupuncture Randomised Controlled Trial to Manage Osteoarthritis of the Knee NCT05507619	Tan Tock Seng Hospital	N/A
Completed	To Evaluate the Efficacy and Safety of Collavant n2 in Individuals With Osteoarthritis of the Knee NCT05474586	Vedic Lifesciences Pvt. Ltd.	N/A
Terminated	Trial Comparing Three Single Dose Injections for Knee Osteoarthritis NCT05492851	Ohio State University	Phase 4
Unknown	Mesenchymal Stem Cell Therapy for Knee Osteoarthritis NCT05288725	Next Generation Regenerative Medicine LLC	Phase 1 / Phase 2
Completed	Robotic Assisted Rehabilitation for Balance and Gait in Orthopedic Patients. NCT05459584	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	N/A
Completed	Effect of Astaxanthin in Moderate to Severe Knee Osteoarthritis NCT05437601	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Phase 2
Unknown	Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of ORTHIX PLUS NCT05348525	Yooyoung Pharmaceutical Co., Ltd.	—
Unknown	Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty NCT05972603	Independent Public Healthcare Center in Rypin	N/A
Completed	Effect of Reparel Knee Sleeve With Knee Injection NCT04859764	University of Alabama at Birmingham	N/A
Unknown	OA Optimization Program Pilot Trial NCT05389371	University of Calgary	Phase 1 / Phase 2
Completed	A First-in-Human Study of XSTEM-OA in Patients With Knee Osteoarthritis NCT05344157	Xindu Pty Ltd	Phase 1 / Phase 2
Completed	OA Clinic-Community CARE Model NCT05349500	University of North Carolina, Chapel Hill	N/A
Completed	Whole-Body Electromyostimulation and Knee Osteoarthritis NCT05672264	University of Erlangen-Nürnberg Medical School	Phase 3
Not Yet Recruiting	RSA Restoris MultiCompartmental Knee NCT05417984	Reinier Haga Orthopedisch Centrum	—
Unknown	Algarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR) NCT05999110	Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv	N/A
Unknown	Effects of Neurodynamics of Pain and Function in Patients With Knee Osteoarthrosis NCT05375448	CEU San Pablo University	N/A
Completed	A Study of the Feasibility of Using the Dietary Supplement "ARTNEO" in Patients With Osteoathritis NCT05975879	NPO Petrovax	N/A
Active Not Recruiting	Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis NCT05387473	Vrije Universiteit Brussel	N/A
Recruiting	Six-month Performance of Meniscal Wall Infiltration Under Ultrasound to Treat Stable Degenerative Meniscal Inj NCT05235854	Centre Hospitalier Universitaire de Nīmes	Phase 1
Active Not Recruiting	Genicular Radiofrequency Ablation Following Total Knee Arthroplasty NCT05283889	University of Calgary	N/A
Completed	Intra-articular Polyacrylamide Hydrogel in the Treatment of Knee Osteoarthritis NCT06523491	Research Centre BIOFORM	—
Completed	Intra-articular Pulsed Radiofrequency in Chronic Knee Pain NCT06017674	Başakşehir Çam & Sakura City Hospital	N/A
Completed	lIfestyle iNterventionS for PaIn ReliEf (INSPIRE) NCT05670314	University of Nottingham	N/A
Unknown	Management of Knee Pain by Cooled Radiofrequency in Classical Anatomical Targets and Revised Targets NCT05363241	Universidade Federal de Alfenas	N/A
Completed	A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of LG00034053 in Patients With Knee OA NCT05237752	LG Chem	Phase 1 / Phase 2
Completed	Ultrasound-guided Injection of Glucocorticoid Into Infrapatellar Fat Pad in Patients With Knee Osteoarthritis NCT05291650	Zhujiang Hospital	Phase 4
Completed	Using Gait Modification to Treat Knee Osteoarthritis in Saudi Arabia: Possibilities and Acceptability. NCT06306079	King Khalid University	N/A
Completed	A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty NCT05053087	Mayo Clinic	Phase 3
Active Not Recruiting	Moving Well for Total Knee Arthroplasty (TKA) NCT05217420	Weill Medical College of Cornell University	N/A
Completed	High-Intensity Laser Therapy: Effectiveness on Knee Osteoarthritis Patients NCT06549543	Baskent University	N/A
Unknown	Development of Spin-lock and FSE Acquisitions Based 3D Quantitative Biochemical Imaging for Osteoarthritis NCT04431752	Chinese University of Hong Kong	—
Completed	A Study to Assess Efficacy of Supporting Properties and Safety of ARTNEO in Patients With Knee Osteoarthritis NCT06032442	NPO Petrovax	N/A
Active Not Recruiting	A Study Evaluating the Safety, Tolerability, and Range of Biologically Active Doses of ICM-203 in Mild to Mode NCT04875754	ICM Biotech Australia Pty Ltd.	Phase 1 / Phase 2
Completed	Knee Osteoarthritis Disabling Pain Program for the Brazilian Unified Health System NCT05286775	Marta Imamura	N/A
Withdrawn	How Does Platelet Dose Impact Clinical Outcomes After PRP Treatment? NCT05330689	Vanderbilt University Medical Center	Phase 2
Recruiting	Cannabinoid Interactions With Central and Peripheral Pain Mechanisms in Osteoarthritis of the Knee NCT04992624	Steven E Harte, PhD	Phase 2
Completed	Investigation of Predisposing Factors Affecting Pain in Patients With Knee Osteoarthritis NCT05238857	Istanbul University	—
Unknown	Study to Assess Signature Cord Product in Patients With Symptomatic OA of the Knee NCT05234489	Thomas Klootwyk, MD	Phase 1
Recruiting	Geniculate Artery Embolization for Osteoarthritis NCT04456569	University of Minnesota	N/A
Unknown	Long-term Safety and Performance of KiOmedine CM-Chitosan Supplementation in Advanced Symptomatic Knee Osteoar NCT05214807	Kiomed Pharma	Phase 4
Completed	Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA NCT04910048	University of Arkansas	N/A
Withdrawn	Outcomes During Digitally Delivered Osteoarthritis Treatment NCT05026580	Joint Academy	—
Completed	Comparison of Kinesio Taping and Dry Needling in Grade 1, 2 Knee Osteoarthritis NCT06086717	Riphah International University	N/A
Completed	The Effect of Radiofrequency Ablation on the Results of the Genicular Nerve Number in the Treatment of Knee Os NCT05447624	Marmara University	N/A
Unknown	Effects of Semi-standarized Acupuncture in Chronical Symptomatic Osteoarthritis of the Knee Through: A Randomi NCT05096806	Universitat de Girona	N/A
Unknown	Radiofrequency Ablation on Pain Relief of Knee Osteoarthritis NCT05050396	Assiut University	N/A
Completed	Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthr NCT05437770	Bispebjerg Hospital	N/A
Completed	The Effects of Intra-articular Platelet-Rich Plasma Injection on The Severity of Knee Osteoarthritis NCT05722626	Universitas Bali Internasional	N/A
Completed	Rural Access to Physical Therapy for Osteoarthritis Rehabilitation - Pilot NCT05114512	University of Pittsburgh	N/A
Completed	Adapting REhabilitation Delivery for Maximum Impact at Home NCT05164575	University of Alberta	N/A
Completed	Extracorporeal Shock Wave Therapy in Osteoarthritis NCT06181955	King Saud University	N/A
Unknown	Continuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip Arthroplasty NCT04444570	Medical University of Warsaw	—
Withdrawn	Oxytocin Pharmacokinetics After Intramuscular Injection NCT04427540	Wake Forest University Health Sciences	Phase 2
Recruiting	Adductor Ratio in Severe Varus Gonarthrosis NCT05936814	Saglik Bilimleri Universitesi	—
Unknown	Comparison of Different Insoles as Conservative Treatment for Medial Knee Osteoarthritis NCT04967339	Insel Gruppe AG, University Hospital Bern	N/A
Unknown	A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improve NCT04938271	Healables Ltd.	N/A
Unknown	Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis NCT04885972	Sorrento Therapeutics, Inc.	Phase 2
Completed	Clinical Efficacy of Platelet-Rich Plasma and Hyaluronic Acid Versus Hyaluronic Acid for Knee Osteoarthritis W NCT06636695	Changi General Hospital	Phase 3
Unknown	Clinical Trial of YYC301 P3 for Treatment of Osteoarthritis of the Knee NCT05362851	Yooyoung Pharmaceutical Co., Ltd.	Phase 3
Completed	Personalized Exercise Therapy and Self-management Support for Patients With Multimorbidity NCT04645732	University of Southern Denmark	N/A
Unknown	Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain NCT04989660	Kessler Foundation	Phase 4
Recruiting	Immuno-based Profiling of knEe OA Patients to Predict reSponse to Regenerative Treatment NCT06384040	Istituto Clinico Humanitas	—
Completed	Predictive Values for the Outcome of Genicular Nerve Radiofrequency Ablation for Chronic Knee Pain NCT05222776	Diskapi Teaching and Research Hospital	—
Unknown	PRP-HA Versus HA in Knee Osteoarthritis NCT05076526	Singapore General Hospital	Phase 2 / Phase 3
Active Not Recruiting	Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Kn NCT04809376	Paradigm Biopharmaceuticals USA (INC)	Phase 2 / Phase 3
Completed	Study of Pain Catastrophizing-2 (SPAC-2) NCT04805190	University of Florida	N/A
Completed	Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA) NCT05027581	Taiwan Bio Therapeutics Inc.	Phase 2
Unknown	Does Electrocautery Increase Postoperative Pain in Primary Total Knee Arthroplasty NCT06239038	Police General Hospital, Thailand	Phase 3
Completed	Comparison Among the Effects of Blood Flow Restriction Training and Conventional Exercise in Knee Osteoarthrit NCT05058794	Riphah International University	N/A
Unknown	Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1) NCT05060107	Francisco Espinoza	Phase 1
Recruiting	Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis NCT05559463	University of California, San Diego	N/A
Active Not Recruiting	Efficacy and Safety Trial of PTP-001 (MOTYS) for Symptomatic Knee Osteoarthritis NCT05100225	Bioventus LLC	Phase 2
Unknown	Epidemiology and Nutrition NCT05546541	I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio	—
Active Not Recruiting	Prediction AlgoriThm for regeneraTive Medicine Approach in knEe OA: New Decision-making Process Based on Patie NCT05447767	Istituto Clinico Humanitas	N/A
Completed	A Clinical Trial Investigating the Effect of Salmon Bone Meal on Osteoarthritis Among Men and Women NCT05070871	Hofseth Biocare ASA	N/A
Completed	Positive Cueing in Knee Arthroplasty. NCT05703087	Leiden University Medical Center	N/A
Withdrawn	Audio-Recorded vs. Nurse-Led Brief Mindfulness-Based Intervention NCT05054595	University of Utah	N/A
Completed	The POMELO (Prevention Of MusclE Loss in Osteoarthritis) Trial NCT05026385	University of Alberta	N/A
Completed	MAKO Total Knee Artroplasty NCT05744895	Washington University School of Medicine	—
Completed	Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee NCT04120402	Eupraxia Pharmaceuticals Inc.	Phase 2
Completed	The Instant Effect of Kinesiology Taping in Patients With Knee OA NCT05160246	Kırıkkale University	N/A
Unknown	Intraoperative Soft Tissue Balance in TKA NCT05006274	Washington Hospital Healthcare System	—
Unknown	Implementation of GLA:D Program in West Virginians With Osteoarthritis of the Knee NCT04857879	Marshall University	N/A
Completed	Tranexamic Acid and Drain Use in Knee Arthroplasty NCT07174895	Idlib University	N/A
Completed	Preventing Posttraumatic Osteoarthritis With Physical Activity Promotion NCT04906499	University of North Carolina, Chapel Hill	N/A
Withdrawn	Transcatheter Arterial Embolization in Patients With Mild to Moderate Osteoarthritis NCT05013970	Universitaire Ziekenhuizen KU Leuven	N/A
Unknown	Cannabinoid Tablets for the Treatment of Pain From Osteoarthritis of the Knee NCT04992962	Pure Green	Phase 2
Recruiting	Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement NCT04732962	Geisinger Clinic	N/A
Completed	Validation of a Surgical Navigation Algorithm During Knee Replacements in Patients With Knee Osteoarthritis NCT04912908	Ganymed Robotics	—
Unknown	Technology and System for Minimally Invasive TKA Surgery Robot NCT04953988	Peking University Third Hospital	N/A
Unknown	CONNACT OA Knee Cohort NCT04942236	Tan Tock Seng Hospital	—
Unknown	A Cohort Study of Non-surgical Treatment and Exercise Rehabilitation in Patients With Anterior Cruciate Ligame NCT05403905	Peking University Third Hospital	N/A
Recruiting	Non-invasive Evaluation of Upper and Lower Body Function With Showmotion NCT04137835	University of Colorado, Denver	N/A
Withdrawn	Study of AlloGen® Liquid Intra-articular Injection for Knee Osteoarthritis NCT04835389	VIVEX Biologics, Inc.	Phase 1
Active Not Recruiting	Corticosteroid Meniscectomy Randomized Trial NCT04641351	The Cleveland Clinic	Phase 4
Unknown	The Impact of Covid-19 on Patients Waiting for Knee Surgery NCT05124613	University of Manchester	—

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