NCT07364578

Probiotic Supplements in Osteoarthritis

Evaluating the Efficacy of Probiotic Supplements on Osteoarthritis Patients

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 146 (estimated)
• Sponsor: Beni-Suef University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The current study aims to evaluate the effectiveness of adding probiotics to the standard of care in improving OA patient-related outcomes such as pain, stiffness, and physical activity.

Detailed description

Osteoarthritis (OA) is a severe progressive chronic arthropathy causing articular remodeling and inflammation of synovial tissue. The disease involves the entire synovial joint, including the cartilage, joint lining, and subchondral bone. OA causes pain, swelling, and stiffness, consequently hindering the patient's ability to perform their main daily activities, which often leads to social isolation and depression. Up till now, there is no cure for OA treatment options target either symptomatic relief (mainly pain) such as acetaminophen, glucosamine, chondroitin sulfate, and non-steroidal anti-inflammatory drugs (NSAIDs) or structure repair. Probiotics are live and active microorganisms widely known as the gut's beneficial bacteria. They are taken to alter the GI flora and provide health benefits such as achieving optimal digestion and immunological function.

Conditions

• Osteoarthritis, Knee

Interventions

Type	Name	Description
DRUG	Probiotic Formula	probiotic supplements (lactobacillus, 2 times daily) added to standard of care
DRUG	Control	standard of care

Timeline

• Start date: 2025-02-15
• Primary completion: 2026-02-15
• Completion: 2026-03-01
• First posted: 2026-01-23
• Last updated: 2026-01-30

Locations

1 site across 1 country: Egypt