NCT06269549

Kinesiological / Dietary Supplement Intervention in Knee Osteoarthritis

Effectiveness of Kinesiological and Dietary Supplement Intervention in Individuals With Knee Osteoarthritis

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 93 (estimated)
• Sponsor: University of Primorska · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to assess the effectiveness of dietary supplement combined with exercise in managing knee osteoarthritis (KOA). The main questions it aims to answer are: * Is adding a dietary supplement to exercise additionally effective in managing KOA? * Is adding exercise to the dietary supplement additionally effective in managing KOA? Participants will be given in three groups: 1. Real dietary supplement alone 2. Real dietary supplement with exercise 3. Placebo dietary supplement with exercise Investigators will compare groups 1 and 2, or 2 and 3, to answer the research questions. The hypothesis is that participants who receive the dietary supplement along with exercise will experience greater reduction in pain level, improved physical function, and enhanced quality of life compared to those who receive a placebo combined with exercise or dietary supplement alone.

Detailed description

Participant recruitment will take place at the Community Healthcare Center dr. Adolf Drolc Maribor based on the doctor's recommendation. Following an informed discussion about the study and potential risks, all patients providing written consent will undergo a one-week screening period to determine eligibility for study entry. At week 0, participants who choose to join an exercise group will be randomly assigned in a 1:1 ratio to either dietary supplements combined with exercise, or placebo dietary supplement combined with exercise. Participants who choose not to participate in exercise will be assigned to the supplement-only grouo, which serves as non-randomized comparator. The effects of the kinesiological / dietary supplement intervention on selected measures will be assessed using a test battery, before and after the 12 week intervention, and at a 6-week post intervention follow-up. Exercise / test batery will be conducted at Community Healthcare Center dr. Adolf Drolc under the supervision of an experienced kinesiologist / investigator. Based on the posed research questions and hypotheses, investigators would like to highlight the following planned statistical analyses. In the case of bilateral KOA, investigators will analyze the more affected knee for differences between groups. In addition to descriptive statistics, investigators will assess normal distribution and homogeneity of variances. Differences between groups will be tested using two-way repeated measures analysis of variance (factor 1 = group, factor 2 = time) and paired two-tailed post-hoc t-tests with Bonferroni correction. The main comparison will be addressed with a 2x2 two-way analysis of variance. The first research question will be addressed with a 2x2 two-way analysis of variance, including groups 2 and 3. The second research question will be addressed with a two-way analysis of variance, including groups 1 and 2. Additionally, effect size will be calculated. The level of statistical significance will be set at p\<0.05.

Conditions

• Osteoarthritis, Knee

Interventions

Type	Name	Description
OTHER	Non-training Real Dietary Supplement (G1)	One capsule of glucosamine three times daily, and one packet of hydrolyzed collagen.
OTHER	Training Placebo Dietary Supplement (G2)	One capsule of placebo glucosamine three times daily, and one packet containing placebo collagen + physical exercise (60 minutes per session twice a week)
OTHER	Training Real Dietary Supplement (G3)	One capsule of glucosamine three times daily, and one packet of hydrolyzed collagen + physical exercise (60 minutes per session twice a week)

Timeline

• Start date: 2024-03-11
• Primary completion: 2026-05-31
• Completion: 2026-06-30
• First posted: 2024-02-21
• Last updated: 2026-02-23

Locations

2 sites across 1 country: Slovenia