NCT05972603

Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty

Can Topical Vancomycin Prevent Periprosthetic Joint Infection in Primary Hip and Knee Arthroplasty? Multicenter Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,000 (estimated)
• Sponsor: Independent Public Healthcare Center in Rypin · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA). We hypothesized that VIP protocol provides superior reduction of periprosthetic joint infection (PJI) rates after primary THA and TKA compared with diluted povidone-iodine (PI) protocol.

Detailed description

Patients who undergo primary hip or knee arthroplasty, before closure 0,35% povidone-iodine (17,5mL in 500 mL saline) solution lavage left for 3 minutes following final implantation. Patients drawn by random numbers calculator will be administered with 1.0 g Vancomycin powder into the wound around the prosthesis and no suction will be used.

Conditions

• Osteoarthritis, Knee
• Osteoarthritis, Hip
• Rheumatoid Arthritis
• Avascular Necrosis of Hip

Interventions

Type	Name	Description
PROCEDURE	1.0 g Vancomycin powder into the wound	0,35% povidone-iodine solution lavage left for 3 minutes following final implantation and additional application 1.0 g Vancomycin powder into the wound
PROCEDURE	0,35% povidone-iodine solution lavage	0,35% povidone-iodine solution lavage left for 3 minutes following final implantation

Timeline

• Start date: 2022-07-01
• Primary completion: 2024-06-01
• Completion: 2024-12-01
• First posted: 2023-08-02
• Last updated: 2023-08-02

Locations

1 site across 1 country: Poland