NCT06000709

Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections

Randomized, Double-blinded, Comparison Between Ultrasound-Guided Genicular Nerve Phenol Neurolysis and Intra-articular Steroid Injections

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Manitoba · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Genicular nerve neurolysis (GN) constitutes a relatively novel technique, whereby different chemical compounds (i.e. alcohol, phenol) are injected in close proximity to the genicular nerves of the knee joint, with the intention to exert a neurolytic effect by denaturing proteins resulting in Wallerian degeneration distal to the lesion. Based on the preliminary evidence and considering the potential benefits of the technique, we hypothesized that ultrasound-guided genicular chemical neurolysis with phenol is superior in terms of pain relief at 3 months, when compared to intra-articular steroid (IAS) injection.

Detailed description

This study will allow us to determine if ultrasound-guided phenol genicular neurolys is superior to intra-articular steroid injection in terms of analgesia and functional outcomes, providing a more effective and long-lasting alternative for patients with chronic knee pain secondary to osteoarthritis

Conditions

• Osteoarthritis, Knee
• Chronic Knee Pain

Interventions

Type	Name	Description
DRUG	6% aqueous phenol	1.5 mL of aqueous phenol will be injected at each target genicular nerve under ultrasound guidance
DRUG	MethylPREDNISolone 40 MG	40 mg of methylprednisolone diluted in 5 mL of 0.9% normal saline will be injected inside the knee joint capsule under ultrasound guidance
DRUG	Intraarticular Knee Placebo	Single injection 1.5 mL of 0.9% normal saline outside the knee joint capsule under ultrasound guidance
DRUG	Genicular Nerve Placebo	1.5 mL of 0.9% normal saline will be injected subcutaneously at each target genicular nerve under ultrasound guidance

Timeline

• Start date: 2023-10-20
• Primary completion: 2024-01-31
• Completion: 2024-07-31
• First posted: 2023-08-21
• Last updated: 2023-10-10