| Recruiting | Evaluation of Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis NCT07471204 | Bahçeşehir University | — |
| Not Yet Recruiting | Robot-Aided Off-Axis Neuromuscular Training for Knee OA NCT07014098 | University of Maryland, Baltimore | N/A |
| Recruiting | Cannabinoids for Osteoarthritis Pain Effectiveness Trial NCT06878417 | University Health Network, Toronto | N/A |
| Not Yet Recruiting | Perioperative Colchicine for TKA NCT06936709 | Geisinger Clinic | Phase 4 |
| Completed | A Phase 1/2a Study to Evaluate Single Intraarticular Injections of 3 Dose Levels of SYN321 and Placebo in Pati NCT06989645 | Synartro AB | Phase 1 / Phase 2 |
| Not Yet Recruiting | Preoperative Rehabilitation Training and Total Knee Arthroplasty Outcomes NCT06983912 | Fuzhou University Affiliated Provincial Hospital | N/A |
| Not Yet Recruiting | The Effect of Balneotherapy on Knee Osteoarthritis NCT07008937 | Ahi Evran University Education and Research Hospital | N/A |
| Not Yet Recruiting | Proprioceptive Fatigue Adaptation in Osteoarthritis NCT06972186 | Kocaeli Sağlık ve Teknoloji Üniversitesi | N/A |
| Active Not Recruiting | A Phase 1/2a to Evaluate the Safety and Efficacy of Adipose Tissue Allograft (BRC-OA) in Patients With Osteoar NCT06828666 | Britecyte | Phase 1 / Phase 2 |
| Active Not Recruiting | A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms NCT06693648 | Amzell | Phase 3 |
| Not Yet Recruiting | Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic an NCT06709703 | Université de Sherbrooke | N/A |
| Not Yet Recruiting | Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? NCT06767787 | Memorial University of Newfoundland | N/A |
| Recruiting | Knee Injections for Obese Patients With Knee Arthritis NCT06782529 | Mayo Clinic | Phase 4 |
| Recruiting | Evaluating the Effectiveness of Using a Home Laser Device to Treat Patients With Knee Osteoarthritis NCT06773676 | Barzilai Medical Center | N/A |
| Active Not Recruiting | RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK) NCT06654739 | DJO UK Ltd | N/A |
| Recruiting | Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries NCT06651762 | Ain Shams University | N/A |
| Active Not Recruiting | Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplan NCT06644092 | Yeditepe University | N/A |
| Completed | Computer-guided Action Planning to Support Physical Activity (CAPPA) for Employees With Chronic Knee Symptoms NCT06734052 | Marquette University | N/A |
| Completed | Electrical Dry Needling Versus Iontophoresis in Treating Chronic Unilateral Knee Osteoarthritis NCT06578663 | Horus University | N/A |
| Active Not Recruiting | Genicular Radiofrequency Ablation Versus Pulsed Radiofrequency NCT06894147 | Ankara City Hospital Bilkent | N/A |
| Unknown | Effect of Overdose Ultrasound on Osteoarthritic Knee in Adult Albino Rat: a Histological Study NCT06774469 | Cairo University | N/A |
| Completed | Effect of Video-based Game and Aerobic Exercise on Knee Osteoarthritis NCT06885008 | Hasan Kalyoncu University | N/A |
| Unknown | Clinical Trial to Assess Efficacy, Tolerability of Rising Doses of Clodronate in Painful Knee Osteoarthritis P NCT06263517 | SPA Società Prodotti Antibiotici S.p.A. | Phase 2 / Phase 3 |
| Recruiting | Surgical Outcome After Displaced Bucket-handle Meniscal Lesions - Repair Versus Partial Meniscectomy NCT07079254 | Region Skane | — |
| Completed | Functional and Clinical Outcomes of Hyaluronic Acid and Steroid Injections in Bilateral Knee Osteoarthritis NCT06717529 | Edin Mešanović | Phase 4 |
| Completed | Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis NCT06254976 | Kayseri City Hospital | N/A |
| Completed | Clinical Trial to Evaluate Safety and Efficacy of MesoCellA-Ortho Tissue-Engineered Advanced Therapy Product i NCT05081921 | Jagiellonian University | Phase 1 / Phase 2 |
| Completed | Efficacy and Safety of Sinovial®HL Single Injection in the Knee Osteoarthritis NCT06652893 | Marcin Domżalski | — |
| Completed | Clinical Efficacy and Safety of NEOIAL HC for Intra-articular Use in the Treatment of Severe Knee Osteoarthrit NCT05936762 | Nextrasearch S.r.l.s. | Phase 4 |
| Completed | Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Art NCT06837012 | Orthopaedic Arthroscopy Knee and Shoulder Clinic | Phase 4 |
| Completed | Efficacy and Safety of DKM420 in Patients With Osteoarthritis of Knee NCT06021444 | Dongkook Pharmaceutical Co., Ltd. | N/A |
| Completed | Efficacy and Safety of MM-II for Treatment of Knee Pain in Subjects With Symptomatic Knee Osteoarthritis NCT04506463 | Sun Pharmaceutical Industries Limited | Phase 2 |
| Completed | Evaluation of Clinical and Radiographic Outcomes of Meniscal Lesion Treatment Using Collagen Scaffolds (CMI) NCT06597357 | Istituto Ortopedico Rizzoli | — |
| Completed | Blood Flow Restriction Exercises and Conservative Exercises in Knee Osteoarthritis NCT04535596 | Istanbul Medipol University Hospital | N/A |
| Completed | Pain Relief for OsteoArthritis Through Combined Treatment (PROACT) NCT03884374 | University of Florida | N/A |
| Completed | Nordic Walking on Knee Osteoarthritis NCT06684574 | Consorci Hospitalari de Vic | N/A |
| Completed | Efficacy of Peripheral Magnetic Stimulation to Reduce Pain in Knee Osteoarthritis. NCT05484752 | Mahidol University | N/A |
| Completed | Evaluation Protocol of the Installation of Knee Unicompartmental Prosthesis (Journey (Smith & Nephew)) With Me NCT03469193 | Hospices Civils de Lyon | N/A |
| Completed | Biofeedback With Cycling Exercise in OA Knee Patients NCT03484910 | China Medical University Hospital | N/A |
| Completed | Mobile Technology to Support Physical Therapy Exercise NCT03428893 | University of Vermont | N/A |
| Unknown | Efficacy of Electro-acupuncture Versus Manual Acupuncture on Knee Osteoarthritis NCT03274713 | zhouping | N/A |
| Completed | Geniculate Artery Embolization for the Treatment of Knee Pain NCT02850068 | University of North Carolina, Chapel Hill | N/A |
| Unknown | Short-term Efficacy of Antidepressant in Patients Underwent TKA NCT03110172 | Dalian Municipal Central Hospital | Phase 1 / Phase 2 |
| Completed | Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL) NCT02830919 | Eurofarma Laboratorios S.A. | Phase 3 |
| Completed | A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the K NCT02893098 | Huons Co., Ltd. | Phase 3 |
| Unknown | Efficacy of Subcutaneous Injection of Etanercept for Moderate and Severe Knee Osteoarthritis NCT02722811 | First Affiliated Hospital of Harbin Medical University | N/A |
| Unknown | Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis NCT02722772 | First Affiliated Hospital of Harbin Medical University | N/A |
| Unknown | Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery NCT02623660 | Bioelectric Research Corporation | N/A |
| Completed | Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patie NCT02682524 | Daewon Pharmaceutical Co., Ltd. | Phase 4 |
| Unknown | Assessment of the Safety and Efficacy of 3VM1001 Cream for Treatment of Chronic Pain Caused by Knee Osteoarthr NCT02332148 | CDA Research Group, Inc. | Phase 1 |
| Completed | Human Autologous MSCs for the Treatment of Mid to Late Stage Knee OA NCT02351011 | Jas Chahal | Phase 1 / Phase 2 |
| Completed | Total Knee Replacement Component Alignment Using Manual Versus Custom Instrumentation NCT02579174 | Northwestern University | N/A |
| Completed | Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA NCT02417506 | Vedic Lifesciences Pvt. Ltd. | N/A |
| Completed | A Clinical Trial to Evaluate the Safety and Efficacy of Retreatment With Intra-articular LBSA0103 Injections i NCT02122601 | LG Life Sciences | Phase 3 |
| Completed | Stability of the Medial Pivot Total Knee Prosthesis NCT02577978 | Northwestern University | N/A |
| Unknown | Trial to Assess the Structural Effect and Long-term Symptomatic Relief of Intra-articular Injections of Hyalur NCT02280538 | Universidade Nova de Lisboa | N/A |
| Completed | Progression of Health Related Quality of Life of Patients Waiting for Total Knee Arthroplasty NCT03492320 | Dr. Ho Ki Wai | — |
| Completed | Allogeneic Mesenchymal Stem Cells in Osteoarthritis NCT01453738 | Stempeutics Research Pvt Ltd | Phase 2 |
| Completed | The Recovery Time of Quadriceps Strength After Total Knee Arthroplasty (TKA): The Effect of Quadriceps Incisio NCT01450904 | Mahidol University | N/A |
| Completed | Accuracy of MRI-based Patients Matched Instruments vs Jig-based Instruments in Total Knee Arthroplasty (TKA) NCT01449474 | Mahidol University | N/A |
| Completed | Feasibility of Outpatient Total Knee Arthroplasty NCT01186211 | Ottawa Hospital Research Institute | — |
| Unknown | Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty NCT01027819 | Seoul National University Hospital | Phase 4 |
| Completed | Whole-body Vibration Training on Functional Performance of the Elderly With Knee Osteoarthritis NCT03918291 | Federal University of the Valleys of Jequitinhonha and Mucuri | N/A |
| Completed | Temporary Clamping of Drains Combined With Tranexamic Acid Reduce Blood Loss After TKA: A Prospective RCT NCT01449552 | Mahidol University | N/A |
| Completed | Efficacy of Flavocoxid 500 mg Compared With Naproxen 500 mg in Subjects With Moderate-severe Osteoarthritis of NCT00790985 | Primus Pharmaceuticals | N/A |
| Active Not Recruiting | Outcome Following Orthopaedic Surgery NCT00261066 | Ottawa Hospital Research Institute | — |