NCT06782529

Knee Injections for Obese Patients With Knee Arthritis

Comparison of Varying Doses of Steroid for Intra-articular Knee Injections

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Mayo Clinic · Academic / Other
• Sex: All
• Age: 55 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.

Conditions

• Osteoarthritis of Knee

Interventions

Type	Name	Description
DRUG	Triamcinolone Acetonide Low Dose	Subjects will receive a reduced dose of 20mg of triamcinolone acetonide. Total injection volume of 5ml, consisting of: * 0.5ml triamcinolone acetonide (20mg) * 4.5ml lidocaine (45mg)
DRUG	Triamcinolone Acetonide Standard Dose	Subjects will receive the standard of care dose of 40mg triamcinolone acetonide Total injection volume of 5ml, consisting of: * 1ml triamcinolone acetonide (40mg) * 4ml lidocaine (40mg)

Timeline

• Start date: 2025-01-24
• Primary completion: 2027-01-24
• Completion: 2027-01-24
• First posted: 2025-01-20
• Last updated: 2026-03-10

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study