NCT06972186

Proprioceptive Fatigue Adaptation in Osteoarthritis

Neuromotor Adaptation to Fatigue: Changes in Lower Extremity Proprioception in Patients With Osteoarthritis

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Kocaeli Sağlık ve Teknoloji Üniversitesi · Academic / Other
• Sex: Female
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.

Detailed description

Osteoarthritis, particularly knee osteoarthritis (gonarthrosis), is a progressive musculoskeletal disease that severely affects lower extremity functions. Proprioceptive impairments in these patients can lead to altered motor control, reduced movement accuracy, and increased risk of falls. Fatigue may exacerbate these impairments by affecting sensory feedback from muscle spindles and joint receptors, which is critical for joint stability and motor control. In postmenopausal women, hormonal changes further compound muscle weakness and joint instability, highlighting the clinical importance of understanding proprioceptive changes following fatigue. This experimental study will involve two groups: postmenopausal women with gonarthrosis and age-matched healthy controls. Participants will undergo an isokinetic fatigue protocol followed by assessments of passive and active joint position sense being more vulnerable. Understanding these changes will contribute to developing rehabilitation strategies focusing on proprioception and fatigue management. We expect that isokinetic fatigue will impair proprioception, with active joint position

Conditions

• Osteoarthritis of Knee
• Proprioception
• Isokinetic Test
• Gonarthritis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Fatigue Protocol + Joint Position Sense Testing	Groups will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.

Timeline

• Start date: 2025-06-01
• Primary completion: 2025-10-01
• Completion: 2025-12-01
• First posted: 2025-05-14
• Last updated: 2025-05-14