NCT03110172

Short-term Efficacy of Antidepressant in Patients Underwent TKA

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 32 (estimated)
• Sponsor: Dalian Municipal Central Hospital · Academic / Other
• Sex: All
• Age: 51 Years – 85 Years
• Healthy volunteers: Accepted

Summary

By taking certain antidepressant in early postoperative period，which is supposed to improve the psychological status of patients with osteoarthritis, explore the effect of certain antidepressant on the recovery of the early stage after the operation of knee joint replacement.

Detailed description

In this study, the investigators are going to investigate the efficacy of Duloxetine on pain, physical function, mental health and quality of life in patients underwent TKAs. The control group is going to be given celecoxib 200mg/24h to 2 weeks after operation.On the basis of the above scheme, the treatment group is going to receiving duloxetine 60mg/24h to 8 weeks after operation.HAMD-17 scale, KSS scale, SF-36 scale and WOMAC scale will be used to evaluate the two groups before and after operation for 4 and 8 weeks.

Conditions

• Osteoarthritis Of Knee

Interventions

Type	Name	Description
DRUG	Duloxetine Hydrochloride	The treatment group will receive duloxetine 60mg/24h to 8 weeks after operation

Timeline

• Start date: 2017-01-01
• Primary completion: 2017-06-01
• Completion: 2017-07-01
• First posted: 2017-04-12
• Last updated: 2017-04-14

Locations

1 site across 1 country: China