NCT06328062

Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA

Comparison Efficacy of Mirogabalin and Pregabalin in Total Knee Arthroplasty. a Randomized Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Thammasat University Hospital · Academic / Other
• Sex: All
• Age: 50 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty. The main question\[s\] it aims to answer are: • Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty. Participants will randomized to mirogabalin or pregabalin group and will take the drug for 6 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.

Detailed description

After surgery is complete, you will be randomly assigned to receive painkillers Mirogabalin or Pregabalin along with other standard medications. Surgery by Mirogabalin group: Participants received 5 mg of mirogabalin, taken as half a tablet, every day. Twice a day, after breakfast and dinner, for 6 weeks. In the pregabalin group: Participants received 50 mg of pregabalin, one tablet taken daily. Twice a day, after breakfast and dinner, for 6 weeks

Conditions

• Pain Postoperative
• Osteoarthritis
• Total Knee Arthroplasty

Interventions

Type	Name	Description
DRUG	Mirogabalin	Participants will receive 5 mg of mirogabalin, taken as half a tablet, every day twice a day, after breakfast and dinner, for 6 weeks.
DRUG	Pregabalin	Participants will receive 50 mg of pregabalin, taken as a tablet, every day twice a day, after breakfast and dinner, for 6 weeks.

Timeline

• Start date: 2024-04-01
• Primary completion: 2025-05-31
• Completion: 2025-05-31
• First posted: 2024-03-25
• Last updated: 2025-04-09

Locations

1 site across 1 country: Thailand